A5020895575- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Stroke Rehabilitation and Recovery
- Dysphagia Assessment and Management
- Moyamoya disease diagnosis and treatment
- Cerebrovascular and genetic disorders
- Atrial Fibrillation Management and Outcomes
- Voice and Speech Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- Herpesvirus Infections and Treatments
- Nutrition and Health in Aging
- Aortic Disease and Treatment Approaches
- Viral Infections and Immunology Research
- Virology and Viral Diseases
- Autoimmune and Inflammatory Disorders
- Cardiac tumors and thrombi
- Asthma and respiratory diseases
- Microgrid Control and Optimization
- Toxoplasma gondii Research Studies
- Cardiovascular Health and Disease Prevention
- Immune Response and Inflammation
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Brain Metastases and Treatment
Hiroshima University
2016-2023
National Cerebral and Cardiovascular Center
2003-2019
Fuji Heavy Industries Health Insurance Society Ota Memorial Hospital
2017
Hiroshima City Asa Citizens Hospital
2016
Center for Rheumatology
2002
Background and Purpose- The ring finger protein 213 gene ( RNF213) is a susceptibility for moyamoya disease large-artery ischemic stroke in East Asia. We examined the prevalence correlates of RNF213 p.R4810K variant patients with early-onset Japanese single-center cohort. Methods- analyzed 70 intracranial arterial stenosis who developed noncardioembolic or transient attack from 20 to 60 years age. Patients were excluded. Results- was found 17 (24%), more often women than men (38% versus 16%,...
During ion transfer through a water–oil interface, water finger (WF) is transiently formed and breaks to leave hydrated ions in the oil phase. The present work investigated subsequent microscopic processes following WF by molecular dynamics (MD) simulation. nascent tend have excessive hydrating as consequence of unstable formation, implying relaxation. Subsequent kinetics including evaporation/condensation water, diffusion, recapture WF, pair formation were comprehensively examined with...
Background:We determined the 2-year long-term risk-benefit profile in patients with stroke or transient ischemic attack (TIA) receiving warfarin direct oral anticoagulants (DOACs) for nonvalvular atrial fibrillation (NVAF) using a prospective, multicenter, observational registry Japan.
The term "oral frailty" reflects the fact that oral health is associated with physical frailty and mortality. gold standard methods for evaluating swallowing function have several problems, including need specialized equipment, risk of radiation exposure aspiration, general physicians not possessing requisite training to perform examination. Hence, simple non-invasive techniques been developed function, such as those measuring tongue pressure thickness. aim this study was investigate...
We investigated the association between results of a simplified cough test and pneumonia onset in 226 patients with acute stroke admitted to Suiseikai Kajikawa Hospital from April December, 2018. For test, performed on admission, orally inhaled mist 1% citric acid-physiological saline using portable mesh nebulizer. When first was evoked or if it remained absent for 30 seconds (indicating an abnormal result), ended. Patients also completed repetitive saliva swallowing (RSST) modified water...
Th2 and Th1 cells have been suggested to express CCR3/CCR4 CCR5/CXCR3, respectively.We examined CCR3, CCR4, CCR5 CXCR3 expression cytokine production in peripheral blood CD4+ T from patients with atopic dermatitis (AD), which has postulated be a Th2-type cell-mediated disease, then analysed the possible correlation between these values levels of several clinical parameters.Intracellular chemokine receptor 40 AD 20 sex- age-matched healthy control subjects were studied by flow cytometry.The...
Background We aimed to clarify associations between prior anticoagulation and short- or long-term clinical outcomes in ischemic stroke transient attack patients with nonvalvular atrial fibrillation. Methods Results A total of 1189 fibrillation who were hospitalized within 7 days after onset analyzed. Of these, 813 (68.4%) received no anticoagulation, 310 (26.1%) warfarin treatment an international normalized ratio ( INR ) <2 on admission, 28 (2.4%) ≥2 the remaining 38 (3.2%) direct oral...
Abstract Associations between cognitive decline and cerebral microbleeds (CMBs) have received increasing attention. An association CMB distribution (deep or lobar) has been reported, but these findings are controversial. We investigated the magnetic resonance imaging (MRI) findings, including CMBs, function in patients with first-ever lacunar infarction. retrospectively included consecutive admitted infarction identified by MRI from July 1, 2011, to December 31, 2018. excluded diagnosed...
The goal of this study was to determine whether nuclear factor-κB (NFκB) and activator protein 1 (AP-1) were the responsible transcription factors for induction proinflammatory cytokines in hen vaginal cells stimulated by different Toll-like receptor (TLR) ligands. Cultured treated with or without poly I:C (TLR3 ligand; dsRNA virus), lipopolysaccharide (LPS) (TLR4 gram-negative bacteria), flagellin (TLR5 bacterial flagellum), R848 (TLR7 ssRNA CpG-oligodeoxynucleotide (CpG-ODN) (TLR21...
2004年~2016年で成人無菌性髄膜炎437例中,水痘・帯状疱疹ウイルス(varicella zoster virus; VZV)髄膜炎は11例(52.7 ± 14.9歳,すべて男性),頻度は2.5%であった.夏~秋に多く地区の水痘の流行と鏡像的であった.9例は髄液中VZV-DNA陽性,2例はVZV-IgG抗体価指数2以上で診断した.発症7日頃までは前者,以後は後者が有用であった.8例は帯状疱疹が先行,1例は髄膜炎が先行,2例は皮疹を認めなかった.2例はB型肝炎キャリアー,1例はインフルエンザワクチン注射後,1例がステロイド内服中であった.神経合併は三叉神経痛,顔面神経麻痺,舌咽神経痛,Elsberg症候群など認め重症化する症例もあった.
症例は69歳の男性である.入院10日前頃から左下肢に帯状疱疹(herpes zoster; HZ)が出現し,その後四肢痙性運動不全麻痺を発症した.皮疹は左腰髄L2~4領域と全身にも散在していた.脊髄MRIで延髄下端~胸髄Th2の長軸に長いT2強調像で高信号病巣を示した.髄液蛋白増加,リンパ球優位の細胞増加を示し,水痘・帯状疱疹ウイルス(varicella-zoster virus; VZV)DNAが陽性であった.血清抗myelin oligodendrocyte glycoprotein(MOG)抗体が陽性で抗aquaporin4抗体は陰性であった.肺炎と肝障害も認め,皮疹の状況から汎発性HZと思われた.HZが引き金となり,抗MOG抗体が産生されて,脊髄炎が発症した病態が推察された.
Contrast-induced encephalopathy (CIE) is a rare complication of contrast agent use. We herein report case acute lacunar infarction in 70-year-old woman. During diagnostic cerebral angiography for asymptomatic common carotid stenosis, she experienced transient drowsiness. After angiography, generalized tonic-clonic seizures occurred her left arm and leg, with eye deviation to the left. The patient was diagnosed CIE due onset symptoms during characteristic computed tomography findings...
Previous studies have revealed that hematoma growth mainly occurs during the first 6 h after onset of spontaneous intracerebral hemorrhage (ICH). Early lowering blood pressure (BP) may be beneficial for preventing growth. However, relationships between timing BP and in ICH remain unclear. We investigated associations ICH.The Stroke Acute Management with Urgent Risk-factor Assessment Improvement (SAMURAI)-ICH Study was a multicenter, prospective, observational study investigating safety...
Wall shear stress (WSS) is the frictional force caused by viscous blood flowing along vessel wall. Decreased WSS associated with local vascular endothelial dysfunction and atherosclerosis. The vector flow mapping (VFM) technique detects direction of intracardiac on wall echocardiography. In this study, we examined carotid applying VFM to arteries evaluated its relationship cerebral small disease (SVD).This a single-center, prospective, observational study. We investigated association between...
A 70-year-old woman developed acute cerebral infarction. Transthoracic echocardiography showed a large mobile mass in the left atrium, suggesting cardiac myxoma as most likely diagnosis. Surgical exploration revealed papillary fibroelastoma originating from coumadin ridge, which is fairly rare but important source of embolization.
Abstract Introduction Poststroke depression (PSD) negatively affects the functional outcome of stroke patients. Patient Health Questionnaire‐9 (PHQ‐9) is a validated screening tool for detecting PSD. This study investigated relationship between PHQ‐9 score and outcomes in patients convalescent rehabilitation ward by evaluating independence measure (FIM) gain scores proportion discharged. Methods In this retrospective conducted from January 2017 to September 2019, consecutive who were...
Strains of Streptococcus mutans expressing the cell surface collagen-binding protein, Cnm, encoded by cnm (cnm-positive S. mutans), are associated with hypertensive intracerebral hemorrhage (ICH) and occurrence cerebral microbleeds (CMBs). Small diffusion-weighted imaging (DWI) hyperintensities in patients acute ICH also CMBs. However, association between cnm-positive DWI is unclear. Hence, this study aimed to investigate ICH.Patients were prospectively registered at three hospitals. Dental...
Elevated serum alkaline phosphatase (ALP) levels are associated with an increased risk of cerebrocardiovascular diseases. However, the associations ALP peripheral arterial disease (PAD) and outcomes in patients acute ischemic stroke (AIS) not well-known.We examined association between ankle-brachial index (ABI) 2111 consecutive AIS. A poor functional outcome was defined as a modified Rankin Scale (mRS) score 3-6 at 3 months after stroke. low ABI value ≤ 0.9.Of total cohort, 482 (22.8%) had...
Abstract The term “oral frailty” reflects the fact that oral health is associated with physical frailty and mortality. Tongue thickness measurement one of evaluations for swallowing function. aim this study was to investigate relationship between tongue pressure in Japanese elderly. We evaluated 254 elderly patients; all participants underwent ultrasonography measurement. To determine thickness, we measured vertical distance from surface mylohyoid muscle dorsum using ultrasonography. Result...