A5058377311- Nitric Oxide and Endothelin Effects
- Hormonal Regulation and Hypertension
- Renin-Angiotensin System Studies
- Adipose Tissue and Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Blood Pressure and Hypertension Studies
- Cardiovascular Disease and Adiposity
- Eicosanoids and Hypertension Pharmacology
- Cardiac Imaging and Diagnostics
- Cell death mechanisms and regulation
- Adipokines, Inflammation, and Metabolic Diseases
- Lipoproteins and Cardiovascular Health
- Liver Disease Diagnosis and Treatment
- Bone health and osteoporosis research
- Signaling Pathways in Disease
- Inflammatory mediators and NSAID effects
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Protease and Inhibitor Mechanisms
- Diabetes Treatment and Management
- Peptidase Inhibition and Analysis
- Chronic Kidney Disease and Diabetes
- S100 Proteins and Annexins
- Cardiovascular and exercise physiology
- Peroxisome Proliferator-Activated Receptors
National Institute of Fitness and Sports in Kanoya
2018-2024
Kagoshima University
2024
Kobe Pharmaceutical University
2024
Osaka University
2003-2023
Kumamoto University Hospital
2010-2015
Kumamoto University
2010-2015
Max Planck Institute for Heart and Lung Research
2015
Gunma University
2015
Japan Society for the Promotion of Science
2013
The University of Tokyo
2013
Vascular ageing is accelerated in patients with diabetes. However, the underlying mechanism remains unclear. Here, we show that high glucose induces activation of apoptosis signal-regulating kinase 1 (ASK1), an apoptosis-inducing signal mediates endothelial cell senescence induced by hyperglycemia. High a time-dependent increase levels ASK1 expression and its activity human umbilical vein cells (HUVECs). Incubation increased proportion expressing senescence-associated beta-galactosidase...
Sirt7, 1 of the 7 members mammalian sirtuin family, promotes oncogenic transformation. Tumor growth and metastasis require fibrotic angiogenic responses. Here, we investigated role Sirt7 in cardiovascular tissue repair process.In wild-type mice, expression increased response to acute injury, including myocardial infarction hind-limb ischemia, particularly at active wound healing site. Compared with homozygous Sirt7-deficient (Sirt7(-/-)) mice showed susceptibility cardiac rupture after...
Joint range of motion (ROM) is an important parameter for athletic performance and muscular injury risk. Nonetheless, a complete description factors influencing ROM among individuals between men women lacking. We examined whether passive muscle stiffness (evaluated by angle-specific shear modulus), tolerance to stretch modulus at end-ROM), slack angle the triceps surae are associated with individual variability sex difference in dorsiflexion ROM, using ultrasound wave elastography. For men,...
There are currently no specific strategies for the treatment or prevention of vascular dementia. White matter lesions, a common pathology in cerebral small vessel disease, major cause We investigated whether apoptosis signal-regulating kinase 1 (ASK1) might be key molecule hypoperfusion, associated with blood-brain barrier breakdown and white lesions.A mouse model cognitive impairment was developed by inducing chronic hypoperfusion including corpus callosum via bilateral carotid artery...
To define the pathophysiological role of nitric oxide (NO) released from vascular smooth muscle cells (VSMC), we examined whether NO VSMC induces cytotoxicity in themselves and adjacent endothelial (EC) using a coculture system. Prolonged incubation with interleukin-1 (IL-1) induced large amounts release VSMC. NG-Monomethyl-L-arginine, an inhibitor synthesis, inhibited both by IL-1. In contrast, DNA synthesis cocultured EC was not but rather stimulated prolonged IL-1 or sodium nitroprusside...
Aim: Mice that carry the Klotho mutation ( KL ‐ / ) manifest diverse age‐related disorders similar to those observed in humans. Thus, protein might function as an anti‐aging hormone mammals. Recently, we reported recombinant attenuated apoptosis and cellular senescence endothelial cells, but mechanism remained unclear. Here, designed vitro study test whether inhibitors of extracellular signal‐regulated kinase mitogen‐activated could affect regulation senescence. Methods: Cellular was...
<b><i>Background:</i></b> Periodontitis increases the risk of atherosclerotic cardiovascular disease and ischemic stroke. In this study, we evaluated whether serum antibody levels against individual periodontal pathogens are significantly associated with stroke subtypes their factors. <b><i>Methods:</i></b> Patients acute (n = 132; 74 male 58 female, 71.3 ± 10.7 years) patients no previous 77; 38 39 70.7 9.5 were consecutively enrolled in...
Hyperhomocysteinemia is an independent risk factor for the development of atherosclerosis. However, underlying mechanism endothelial cell injury in hyperhomocysteinemia has not been elucidated. In this study, we examined effect homocysteine (Hcy) on Fas-mediated apoptosis cells. Hcy-induced upregulation Fas cells (ECs) a dose-dependent manner. At same time, Hcy increased intracellular peroxide ECs. expression was inhibited by treatment with catalase. NF-kappaB DNA binding activity, and...
We identified a ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) gene, which encodes deubiquitinating enzyme and is expressed in the vasculature, by functional screening of human endothelial cell (EC) cDNA library. UCHL1 neurons, abnormalities are responsible for inherited Parkinson's disease via its effects on ubiquitin-proteasome system. Therefore, goal present study was to clarify role gene vascular remodeling evaluating nuclear factor-kappaB (NF-kappaB) inactivation ECs smooth muscle...
Type 2 diabetes plays a major role in the development of cardiovascular diseases. The present study was undertaken to investigate effect ezetimibe, potent cholesterol absorption inhibitor, on injury obese and type diabetic <i>db/db</i> mice. Diabetic mice fed Western diet were given ezetimibe for 9 weeks, effects hepatic steatosis examined. Ezetimibe treatment significantly improved vascular endothelial function, which associated with restoration decreased phospho-Akt phospho-endothelial...
Calcium antagonists normalize endothelial dysfunction in many cardiovascular diseases. There is no known receptor, however, for calcium cells (ECs). We hypothesized that vascular smooth muscle (VSMCs) are involved the mechanism underlying normalization of by antagonists.Coculture studies with ECs and VSMCs were performed to determine whether mediate modulation superoxide dismutase (SOD) activity expression induced antagonist nifedipine. Nifedipine upregulation SOD rat aortic segments but had...
This study was performed to determine the characteristics and mechanism of hypertension in SHR/NDmcr-cp(+/+) rats (SHRcp), a new model metabolic syndrome, with focus on autonomic nervous system, aldosterone, angiotensin II.We measured arterial blood pressure (BP) SHRcp by radiotelemetry combined spectral analysis using fast Fourier transformation algorithm examined effect azilsartan, an AT1 receptor blocker. Compared control Wistar-Kyoto (WKY) SHR, exhibited nondipper-type displayed...
CYP4A11 oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid, a metabolite with renovascular and tubular function in humans. A previous study demonstrated significant association between the gene polymorphism hypertension; however, precise mechanism of has not been clarified. To assess involvement pathogenesis hypertension, we sought identify functional examined its impact on predisposition hypertension Tanno-Sobetsu Study. The −845A/G was identified promoter region by direct...
Objective— Whole-body periodic acceleration (WBPA) has been developed as a passive exercise technique to improve endothelial function by increasing shear stress through repetitive movements in spinal axis direction. We investigated the effects of WBPA on blood flow recovery mouse model hindlimb ischemia and patients with peripheral arterial disease. Methods Results— After unilateral femoral artery excision, mice were assigned either (n=15) or control (n=13) group. was applied at 150 cpm for...
In the intrinsic pathway of apoptosis, mitochondria play a crucial role by releasing cytochrome c from intermembrane space into cytoplasm. Cytochrome release through Bax/Bak-dependent channels in has been well documented. contrast, cyclophilin D (CypD), an important component permeability transition pore-dependent protein release, remains largely undefined, and no apoptogenic proteins that act specifically CypD-dependent manner have reported to date. Here, we describe novel evolutionarily...