A5056441333- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Growth Hormone and Insulin-like Growth Factors
- Cholesterol and Lipid Metabolism
- Neuroendocrine Tumor Research Advances
- Diet, Metabolism, and Disease
- Cardiovascular Health and Disease Prevention
- Neuroblastoma Research and Treatments
- Cardiovascular Function and Risk Factors
- Pituitary Gland Disorders and Treatments
- Liver Disease Diagnosis and Treatment
- Adrenal and Paraganglionic Tumors
- Hormonal Regulation and Hypertension
- Peroxisome Proliferator-Activated Receptors
- Cancer, Hypoxia, and Metabolism
- Mercury impact and mitigation studies
- Blood Pressure and Hypertension Studies
- Pancreatic and Hepatic Oncology Research
- Diabetes Treatment and Management
- Adipose Tissue and Metabolism
- Drug Transport and Resistance Mechanisms
- Thyroid Disorders and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer, Lipids, and Metabolism
- Lung Cancer Research Studies
Kagawa University
2016-2025
Kagawa University Hospital
2016
Takamatsu University
2014
National Institute for Minamata Disease
1986-2009
Shimane University
2008
Scripps Research Institute
2008
University of Calgary
1997-2007
Jesse Brown VA Medical Center
2007
University of Illinois Chicago
2007
Tokushima University
2003
Recent studies suggest that metformin, which is commonly used as an oral anti-hyperglycemic agent of the biguanide family, may reduce cancer risk and improve prognosis, but mechanisms by metformin affects various cancers, including gastric cancer, remains unknown. The goal present study was to evaluate effects on human cell proliferation in vitro vivo microRNAs (miRNA) associated with antitumor effect metformin. We MKN1, MKN45, MKN74 lines cells. Athymic nude mice bearing xenograft tumors...
Recently, a murine scavenger receptor type B class I (SR-BI) was identified that binds high density lipoprotein (HDL) and mediates the selective uptake of cholesterol esters. The human CD36 LIMPII analogous-1 (CLA-1) shows sequence homology with SR-BI, but their functional relationship has not been determined. Transfected cells expressing CLA-1 bound HDL K d about 35 μg/ml, similar to for binding rodent SR-BI. This resulted in an intracellular accumulation HDL-derived [3H]cholesterol esters...
High-density lipoprotein (HDL) stimulates the growth of many types cells, including those breast cancer. High levels HDL are associated with an increased risk cancer development. A scavenger receptor B class (SR-BI)/human homolog SR-BI, CD36, and LIMPII analogous-1 (CLA-1) facilitates cellular uptake cholesterol from thus augments cell growth. Furthermore, is also believed to have antiapoptotic effects on various types, this feature adds its ability promote These collaborative roles CLA-1...
Metformin is a commonly used oral anti-hyperglycemic agent of the biguanide family. Recent studies suggest that metformin may reduce cancer risk and improve prognosis. However, antitumor mechanism in several types cancers, including hepatocellular carcinoma (HCC), has not been elucidated. The goal present study was to evaluate effects on HCC cell proliferation vitro vivo, microRNAs (miRNAs) associated with effect vitro. We lines Alex, HLE Huh7, normal hepatocytes human cells. In an vivo...
Solid evidence has demonstrated that psychoemotional stress induced alteration of hair cycle through neuropeptide substance P (SP) mediated immune response, the role reactive oxygen species (ROS) in brain-skin-axis regulation system remains unknown.The present study aims to investigate possible mechanisms ROS SP-mast cell signal pathway chronic restraint (CRS, a model stress) which abnormal cycle.Our results have CRS actually altered by inhibiting follicle growth vivo, prolonging telogen...
We have examined the regulation of apolipoprotein A-I (apoA-I) gene expression in response to glucose and insulin. In Hep G2 cells, endogenous apoA-I mRNA was suppressed by one-half or induced 2-fold following 48 h exposure high concentrations (22.4 mm) insulin (100 microunits/ml), respectively, compared with control. Transcriptional activity rat promoter (−474 −7) cells paralleled expression, this dependent on dose Deletional analysis showed that a 50-base pair fragment spanning −425 −376...
Monocytes enter the subendothelial space in response to a variety of chemotactic agents, notably including monocyte protein-1 (MCP-1). To better understand role human MCP-1 receptor (hCCR2) recruitment, we have examined effects cytokines on expression gene by ligand binding and Northern blot analysis. THP-1 cells expressed average about 5000 receptors/cell. Differentiation induced phorbol myristate acetate resulted 75% reduction within 2 h. Macrophage colony-stimulating factor had only...
<b><i>Background:</i></b> Periodontitis increases the risk of atherosclerotic cardiovascular disease and ischemic stroke. In this study, we evaluated whether serum antibody levels against individual periodontal pathogens are significantly associated with stroke subtypes their factors. <b><i>Methods:</i></b> Patients acute (n = 132; 74 male 58 female, 71.3 ± 10.7 years) patients no previous 77; 38 39 70.7 9.5 were consecutively enrolled in...
We conducted a descriptive case study to examine the effects of sodium-glucose cotransporter 2 (SGLT2) inhibitors on urinary angiotensinogen excretion, which represents function intrarenal renin-angiotensin system, in patients with type diabetes. An SGLT2 inhibitor (canagliflozin 100 mg/day, ipragliflozin 25 dapagliflozin 5 luseogliflozin 2.5 mg/day or tofogliflozin 20 mg/day) was administered for 1 month (n=9). ELISA kits were used measure both intact and total levels. Treatment...
We report the case of a 62-year-old man who presented with bilateral adrenal enlargement and systemic lymphadenopathy. Imaging clinical findings led to diagnosis hemorrhage. Bone marrow aspiration lymph node biopsy confirmed TAFRO syndrome, which met established diagnostic criteria. Although hemorrhage in syndrome is exceedingly rare, this unique, as it represents first reported instance massive progression. This underscores need for awareness regarding potential complication syndrome.
Aim: The aim of this study was to investigate the impact sodium-glucose cotransporter 2 (SGLT2) inhibitors on nocturnal polyuria. Additionally, aimed compare short-acting SGLT2 inhibitor tofogliflozin and other inhibitors. Methods: A questionnaire administered 142 patients undergoing treatment for type diabetes assess presence Results: Among 69 not taking (Non-SGLT2-I Group), 41 (59.4%) reported no polyuria, while 28 (40.6%) its presence. In contrast, among 73 (SGLT2-I 34 (46.6%) whereas 39...
The chemokine monocyte chemoattractant protein‐1 is a potent for monocytes. Monocyte produced by vascular endothelial cells during inflammatory diseases such as atherosclerosis. In this study, we examined the effects of thiazolidinedione on expression in human cells. cells, interleukin‐1β and tumor necrosis factor‐α induced endogenous protein secretion, mRNA promoter activity. inhibited these effects. summary, our results indicated that suppression can be accomplished treatment, raising...
Autophagy has emerged as a powerful process in the response to cellular injury. The present study was designed investigate signal transduction pathways angiotensin II (Ang II)-induced autophagy. Rat vascular smooth muscle cells (VSMCs) were stimulated with different doses of Ang (10(-9)-10(-5) mol/L) for time periods (6-72 h). Incubation increased production reactive oxygen species (ROS), LC3-II LC3-I ratio, beclin-1 expression, and decreased SQSTM1/p62 expression dose- time-dependent...
Recent studies suggest that metformin, which is a member of the biguanide family and commonly used as an oral anti-hyperglycemic agent, may reduce cancer risk improve prognosis numerous types cancer. However, mechanisms underlying antitumor effect metformin on esophageal remain unknown. The goal present study was to evaluate effects proliferation human ESCC in vitro, changes expression profile microRNAs (miRNAs), since miRNAs have previously been associated with other cancers. cell lines...
The abundance of HDL particles correlates inversely with the incidence coronary heart disease. human scavenger receptor B1 (hSR-B1/CLA-1) is a for HDL. Expression hSR-B1/CLA-1 mRNA and protein in platelets was determined using reverse transcriptase-polymerase chain reaction Western blot, respectively. Presence on surface shown flow cytometry.Immunochemical staining showed that it expressed megakaryocytes, platelet precursors bone marrow. These findings prompted us to ask whether...