A5032563585- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Hepatitis C virus research
- Hepatocellular Carcinoma Treatment and Prognosis
- MicroRNA in disease regulation
- Cardiovascular Health and Disease Prevention
- Cardiovascular Function and Risk Factors
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Circular RNAs in diseases
- Trace Elements in Health
- Cancer Mechanisms and Therapy
- Systemic Lupus Erythematosus Research
- Metabolism, Diabetes, and Cancer
- Blood Pressure and Hypertension Studies
- Galectins and Cancer Biology
- Cancer-related molecular mechanisms research
- Pediatric Hepatobiliary Diseases and Treatments
- Nutrition and Health in Aging
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immunotherapy and Immune Responses
- Diabetes and associated disorders
- Pancreatitis Pathology and Treatment
- Cardiovascular Disease and Adiposity
- Cancer, Lipids, and Metabolism
Kagawa Prefectural College of Health Sciences
2016-2025
Kagawa University
2013-2024
University of Health Sciences
2014-2023
Tottori University Hospital
2021
University of Health Science
2021
Tottori University
2021
Tenri Health Care University
2021
University of Health Sciences Antigua
2015
Kagawa University Hospital
2010
Scripps Research Institute
2005
Recent studies suggest that metformin, which is commonly used as an oral anti-hyperglycemic agent of the biguanide family, may reduce cancer risk and improve prognosis, but mechanisms by metformin affects various cancers, including gastric cancer, remains unknown. The goal present study was to evaluate effects on human cell proliferation in vitro vivo microRNAs (miRNA) associated with antitumor effect metformin. We MKN1, MKN45, MKN74 lines cells. Athymic nude mice bearing xenograft tumors...
Numerous nutritional factors increase the risk of hepatocellular carcinoma (HCC) development. The dysregulation zinc, copper, and selenium homeostasis is associated with occurrence HCC. impairment these essential trace elements results in oxidative stress, DNA damage, cell cycle progression, angiogenesis, finally leading to hepatocarcinogenesis. These can affect microenvironment carrier proteins for zinc copper selenium-containing enzymes play important roles prevention or progression...
Metformin is a commonly used oral anti-hyperglycemic agent of the biguanide family. Recent studies suggest that metformin may reduce cancer risk and improve prognosis. However, antitumor mechanism in several types cancers, including hepatocellular carcinoma (HCC), has not been elucidated. The goal present study was to evaluate effects on HCC cell proliferation vitro vivo, microRNAs (miRNAs) associated with effect vitro. We lines Alex, HLE Huh7, normal hepatocytes human cells. In an vivo...
Galectin-9, a soluble β-galactoside-binding animal lectin, evokes apoptosis in various human cancer cell lines. The galectin-9 antitumor effect against hepatocellular carcinoma (HCC) is, however, unknown. We investigated whether suppresses HCC growth vitro and vivo. assessed the of on cells by conducting WST-8 assay xenograft model analysis Galectin-9-induced was evaluated FACS ELISA TUNEL stain Cell cycle alteration profiled FACS. Caspases were colorimetry. MicroRNAs related to effects...
Aim Albumin–bilirubin (ALBI) grade was investigated to predict prognosis of patients with cirrhosis. It defined using the ALBI score calculated based on serum total bilirubin and albumin, which represent liver function. The diagnostic accuracy for fibrosis staging in chronic hepatitis has not been well. This study aimed evaluate abilities cirrhosis Japanese C virus (HCV) infection. Methods HCV infection who underwent biopsy examinations were enrolled a retrospective study. Fibrosis activity...
A previous genome-wide association study (GWAS) performed in 963 Japanese individuals (487 primary biliary cholangitis [PBC] cases and 476 healthy controls) identified TNFSF15 (rs4979462) POU2AF1 (rs4938534) as strong susceptibility loci for PBC. In this study, we GWAS additional 1,923 (894 PBC 1,029 controls), combined the results with data. This GWAS, together a subsequent replication an independent set of 7,024 (512 6,512 PRKCB (rs7404928) novel locus (odds ratio [OR] = 1.26, P 4.13 ×...
Direct acting antivirals (DAA) have recently been developed to treat patients with hepatitis C virus (HCV) infection, and interferon-free DAA treatment has improved the cure rate of patients. However, occurrence hepatocellular carcinoma (HCC) following HCV eradication remains unknown. Therefore, present study aimed identify predictors HCC treatment. Among 1,454 infected HCV, 1,088 who achieved sustained virologic response had no history were recruited between September 2014 November 2018....
Abstract Background This retrospective, multicenter study evaluated the effect of pemafibrate treatment on liver function and fibrosis by tests (LFTs) various fibrotic biomarkers including FibroScan in non-alcoholic fatty disease (NAFLD) with hypertriglyceridemia. Methods A total 138 NAFLD patients treated at three hospitals between September 2018 April 2021 were included. To evaluate treatment, FibroScan-aspartate aminotransferase (FAST) score, a novel index steatohepatitis that can be...
Abstract Portal vein thrombosis (PVT) worsens the long-term prognosis of patients with cirrhosis; however, optimal treatment remains to be determined. Reports on efficacy direct oral anticoagulants are increasing, and further evidence is needed. Therefore, we investigated effectiveness edoxaban in PVT. We retrospectively reviewed outcomes warfarin as antithrombotic therapies for The median overall survival time was 4.2 years PVT, a 1-year rate 70.7% 5-year 47.9%. leading cause death...
Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide, with a rising incidence. The therapeutic choice for HCC transarterial chemoembolization (TACE). While standard protocol of TACE adopts cisplatin, application cisplatin needs hydration before and after procedure to alleviate adverse effects on kidney function. Miriplatin, lipophilic platinum complex, enables omission periprocedural compared cisplatin-based TACE. This study aimed compare survival benefit between...
Cholangiocarcinoma (CCA) is at an advanced stage the time of its diagnosis, and developing a more effective treatment CCA would be desirable. Angiotensin II type 1 (AT1) receptor blocker (ARB), telmisartan may inhibit cancer cell proliferation, but mechanisms by which affects various cancers remain unknown. In this study, we evaluated effects on human cells to assess expression microRNAs (miRNAs). We studied using two lines, HuCCT-1 TFK-1. our experiments, inhibited proliferation TFK-1...
Non-alcoholic steatohepatitis (NASH) is one of the most common causes chronic liver disease and considered to be a causative factor cryptogenic cirrhosis hepatocellular carcinoma. microRNAs (miRNAs) are small non-coding RNAs that negatively regulate messenger RNA (mRNA). Recently, it was demonstrated aberrant expression certain miRNAs plays pivotal role in disease. The aim present study evaluate changes miRNA profiles associated with metformin treatment NASH model. Eight-week-old male mice...
Objective. Zinc supplementation has been shown to contribute inhibition of liver fibrosis and improvement in hepatic encephalopathy. However, little is known about the anti-inflammatory effect zinc on hepatitis C virus (HCV)-related chronic disease (CLD). We therefore examined effects administration inflammatory activity patients with HCV-related CLD. Material methods. Polaprezinc, a complex l-carnosine, was administrated at 225 mg/day for 6 months 14 CLD, addition their ongoing...
Hepatitis B virus (HBV)-related hepatocarcinogenesis is not necessarily associated with the liver fibrotic stage and occasionally seen at early stages. MicroRNAs (miRNAs) are essentially 18- to 22-nucleotide-long endogenous noncoding RNAs. Aberrant miRNA expression a common feature of various human cancers. The aberrant specific miRNAs has been shown in hepatocellular carcinoma (HCC) tissue compared nontumor tissue. Thus, we examined targetable as potential new biomarker related high risk...
Colon cancer is the second leading cause of cancer‑related mortality worldwide, and prognosis advanced colon has remained poor in recent years. Galectin‑9 (Gal‑9) a tandem‑repeat type galectin that recently been shown to exert antiproliferative effects on various types cells. The present study aimed assess Gal‑9 human colorectal cells <em>in vitro</em> vivo</em>, as well evaluate microRNAs (miRNAs/miRs) associated with antitumor Gal‑9. We examined ability inhibit cell proliferation via...
Although there have been advances in the prevention and diagnosis of hepatocellular carcinoma (HCC) recent years, many HCC patients are still diagnosed with advanced stage. Systemic therapy is indicated for unresectable (uHCC) major vascular invasion and/or extrahepatic metastases, atezolizumab plus bevacizumab (atezo/bev) combination currently recommended as first-line treatment uHCC. Recently, sarcopenia-related factors, including decreased skeletal muscle index (SMI), reportedly...