A5068540680- Muon and positron interactions and applications
- Particle accelerators and beam dynamics
- Liver Disease Diagnosis and Treatment
- Superconducting Materials and Applications
- Particle physics theoretical and experimental studies
- Atomic and Molecular Physics
- Colorectal Cancer Treatments and Studies
- Liver Diseases and Immunity
- Particle Detector Development and Performance
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Gastric Cancer Management and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Quantum Chromodynamics and Particle Interactions
- Nuclear Physics and Applications
- Nuclear physics research studies
- Liver Disease and Transplantation
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- X-ray Spectroscopy and Fluorescence Analysis
- Particle Accelerators and Free-Electron Lasers
- Cancer Treatment and Pharmacology
- Ammonia Synthesis and Nitrogen Reduction
- Plasma Diagnostics and Applications
- Cancer Diagnosis and Treatment
High Energy Accelerator Research Organization
2016-2025
Japan Proton Accelerator Research Complex
2014-2024
KDDI (Japan)
2011-2023
The Graduate University for Advanced Studies, SOKENDAI
2011-2023
Osaka Hospital
2017-2022
Okayama University
2009-2021
Nishinomiya Municipal Central Hospital
2014-2021
Institute of Materials Structure Science
2010-2021
Japan Atomic Energy Agency
2010-2019
Japan Community Healthcare Organization
2018-2019
This paper introduces a new approach to measure the muon magnetic moment anomaly |$a_{\mu} = (g-2)/2$| and electric dipole (EDM) |$d_{\mu}$| at J-PARC facility. The goal of our experiment is |$a_{\mu}$| using an independent method with factor 10 lower momentum, 20 smaller diameter storage-ring solenoid compared previous ongoing |$g-2$| experiments unprecedented quality storage field. Additional significant differences from present experimental include 1000 transverse emittance beam...
OBJECTIVES Serum levels of des-gamma-carboxy prothrombin (DCP) and alpha-fetoprotein (AFP) are known to be useful tumor markers for the diagnosis hepatocellular carcinoma (HCC). The aim this study was examine diagnostic efficacy DCP AFP in differentiating HCC from chronic liver diseases. METHODS We examined 1,377 patients 355 with hepatitis or cirrhosis (non-HCC) who visited our institute affiliated hospitals between June 1997 September 2003. RESULTS median values were 60 mAU/mL 34 ng/mL...
Oxidative stress is a strong contributor to the progression from simple fatty liver nonalcoholic steatohepatitis (NASH). Molecular hydrogen an effective antioxidant that reduces cytotoxic reactive oxygen species. In this study, we investigated effects of hydrogen-rich water and drug pioglitazone on NASH in mouse models. A methionine-choline–deficient (MCD) diet model was prepared. Mice were divided into three experimental groups fed for 8 weeks as follows: (1) MCD + control (CW group); (2)...
Inconsistent conclusions have been drawn about the clinical significance of micrometastases in lymph nodes (LNs) node-negative colorectal cancer (CRC) patients. We performed a comparative study detection using immunohistochemistry (IHC) by anti-cytokeratin antibody and carcinoembryonic antigen (CEA)-specific reverse-transcriptase polymerase chain reaction (RT-PCR) same patients, an attempt to move closer their application.Sixty-four CRC with RNA good quality available from paraffin-embedded...
Robotic laparoscope positioners are now expected as assisting devices for solo surgery among endoscopic surgeons. In such robotic systems, the human-machine (surgeon-robot) interface is of paramount importance because it means by which surgeon communicates with and controls camera assistant. We have designed a novel interface, called "FAce MOUSe", controlling position laparoscope. The proposed human an image-based system tracks surgeon's facial motions robustly in real time does not require...
Platelet-derived growth factor (PDGF)/PDGFRβ-dependent investment of the vascular endothelium by mural cells (i.e., pericytes and smooth muscle cells; VSMCs) is critical for normal vessel wall structure function. In developing vasculature, cell recruitment associated with functionally undefined expression type I transmembrane proteinase, membrane-type 1 matrix metalloproteinase (MT1-MMP). this paper, using VSMCs tissues isolated from gene-targeted mice, we identify MT1-MMP as a...
Sorafenib, the first agent demonstrated to have efficacy improve survival of patients with advanced hepatocellular carcinoma (HCC), is an active multikinase inhibitor affecting angiogenesis and tumor proliferation. We analyzed cytokines related or cell proliferation, tried determine their utility as biomarkers sorafenib treatment effect for HCC.Nine serum (angiopoietin-2 [Ang-2], follistatin, granulocyte colony-stimulating factor [G-CSF], hepatocyte growth [HGF], interleukin-8 [IL-8],...
A layered iridate Ba${}_{2}$IrO${}_{4}$ was synthesized using a high-pressure synthesis technique. Its electronic state studied through electrical resistivity, magnetic susceptibility, and \ensuremath{\mu}SR experiments. It found that crystallizes in ${\mathrm{K}}_{2}$NiF${}_{4}$-type structure (space group $I$4/mmm) with lattice parameters $a$ $=$4.030(1) \AA{} $c$ $=$13.333(4) \AA{}. The includes flat IrO${}_{2}$ square planar lattices straight Ir-O-Ir bonds. is Mott insulator (activation...
The liver constantly encounters food-derived antigens and bacterial components such as lipopolysaccharide translocated from the gut into portal vein. Bacterial stimulate Toll-like receptors (TLR), which are expressed on Kupffer cells, biliary epithelial hepatocytes, hepatic stellate endothelial cells dendritic recognize specific pathogen-associated molecular patterns. signaling of TLR to its main ligand triggers inflammation. Usually, in order protect against hyperactivation immune system...
Non-alcoholic steatohepatitis (NASH) is a severe form of non-alcoholic fatty liver disease characterized by lobular inflammation, hepatocellular ballooning, and fibrosis with an inherent risk for progression to cirrhosis carcinoma (HCC). Mitochondrial dysfunction appears play role in the from simple steatosis NASH. L-carnitine (L-b-hydroxy-g-N-trimethylaminobutyric acid), essential nutrient that converts fat into energy mitochondria, has been shown ameliorate damage. The aim present study...
Studies have shown the prognostic significance of disseminated tumor cells (DTC) in bone marrow patients with colorectal cancer. However, molecular characteristics DTCs, including their miRNA expression profiles, remain mostly unknown. In this study, we analyzed DTCs marrow. EpCAM(+) were collected using immunomagnetic beads after exclusion CD14(+) and CD45(+) cells, then subjected to microarray analysis. Cluster analysis (7 cancer liver metastasis 12 without metastasis) indicated that...
It is shown that long-period gratings (LPGs) can be written in a pure-silica photonic crystal fiber without physical deformation by using the glass structure change. LPGs with different grating periods are made change induced arc discharge. We find resonance wavelengths decrease increasing period contrast fabricated conventional fibers. The second-order core mode begins to supported long-wavelength region, and two peaks appear there. This due large increase of index difference between holey...
We present evidence for the excitation of two-photon Doppler-free $1S\ensuremath{-}2S$ transition in muonium. Thermal muonium atoms were produced vacuum by a 27.5-MeV/c pulsed positive-muon beam incident on powdered Si${\mathrm{O}}_{2}$ target. Transitions induced light from frequency-doubled dye laser and detected photoionization $2S$ state. The $1S(F=1)\ensuremath{\rightarrow}2S(F=1)$ frequency is within 300 MHz QED prediction.
It still remains controversial whether gastric mucosal atrophy and intestinal metaplasia are reversible after eradication of Helicobacter pylori infection. The aims this study were to evaluate the histological changes in mucosa H. during long-term follow-up periods, verify propriety for elderly population.Two hundred forty-one patients with infection 84 cases more than 60 years old classified as group. mean period was 101 months. A series endoscopic examinations five-point biopsies performed...
In order to elucidate the magnetism and Li diffusion in LiFePO${}_{4}$, we have measured muon-spin rotation relaxation (${\ensuremath{\mu}}^{+}$SR) spectra for polycrystalline LiFePO${}_{4}$ sample temperature range between 1.8 500 K. Below ${T}_{\mathrm{N}}\ensuremath{\sim}52$ K, two oscillatory signals together with one fast signal were clearly found zero-field (ZF) ${\ensuremath{\mu}}^{+}$SR spectrum. The three are reasonably explained using an antiferromagnetic (AF) spin structure...
The recent development of the intense pulsed muon source at J-PARC MUSE, Japan Proton Accelerator Research Complex/MUon Science Establishment (106 s−1 for a momentum 60 MeV/c), enabled us to pioneer new frontier in analytical sciences. Here, we report non-destructive elemental analysis using µ− capture. Controlling from 32.5 57.5 MeV/c, successfully demonstrate depth-profile light elements (B, C, N and O) several mm-thick layered materials bulk analyses meteorites containing organic...