A5041602945- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Gastric Cancer Management and Outcomes
- Organ Transplantation Techniques and Outcomes
- Neuroendocrine Tumor Research Advances
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal and GI Pathology
- Gastrointestinal Tumor Research and Treatment
- Pancreatic function and diabetes
- Peroxisome Proliferator-Activated Receptors
- Metabolism and Genetic Disorders
- Gallbladder and Bile Duct Disorders
- Metal and Thin Film Mechanics
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastrointestinal disorders and treatments
- Urinary Bladder and Prostate Research
- Metastasis and carcinoma case studies
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Liver Disease and Transplantation
- Renal cell carcinoma treatment
- Cardiac Imaging and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Hormonal and reproductive studies
- Colorectal Cancer Surgical Treatments
Kagawa University
2015-2025
Ehime University
2025
Nihon University
2008-2024
Gifu University
2000-2024
National Center For Child Health and Development
2007-2023
Surugadai Nihon University Hospital
2020-2023
Hyogo Prefectural Awaji Medical Center
2022-2023
Hebei Rehabilitation Hospital
1989-2022
Kagawa University Hospital
2019-2022
Saiseikai Matsuyama Hospital
2022
The inhibitor of apoptosis (IAP) family anti-apoptotic proteins regulate programmed cell death and/or apoptosis. One such protein, X-linked IAP (XIAP), inhibits the activity proteases, caspase-3, -7, and -9. In this study, using constitutively active mutants we found that XIAP promotes degradation active-form but not procaspase-3, in living cells. mutants, which cannot interact with had little or no promoting caspase-3. RING finger also could promote A proteasome suppressed caspase-3 by...
Significance Metabolic reprogramming is one of the hallmarks cancer. However, underlying mechanisms that regulate cancer metabolism are poorly understood. Here we performed multiomics-based analysis paired normal–tumor tissues from patients with colorectal cancer, which revealed protooncogene protein MYC regulated global metabolic by modulating 215 reactions. Importantly, this occurred in a manner not associated specific gene mutations carcinogenesis. For many years, small-molecule or...
In Brief Objective: The goal of this retrospective study was to clarify the clinical implications status 3 major genes (CDKN2A/p16, TP53, and SMAD4/DPC4). Background: Recent whole-exome sequencing had shown that landscape pancreatic ductal adenocarcinoma (PDAC) genome is notable for 4 frequently mutated (KRAS, CDKN2A/p16, Methods: We determined immunohistochemically SMAD4/DPC4 among because KRAS gene in virtually all PDAC patients, analyzed relationships with clinicopathological findings,...
Recent studies suggest that metformin, which is commonly used as an oral anti-hyperglycemic agent of the biguanide family, may reduce cancer risk and improve prognosis, but mechanisms by metformin affects various cancers, including gastric cancer, remains unknown. The goal present study was to evaluate effects on human cell proliferation in vitro vivo microRNAs (miRNA) associated with antitumor effect metformin. We MKN1, MKN45, MKN74 lines cells. Athymic nude mice bearing xenograft tumors...
We extracted polyphenols from carob (Ceratonia siliqua L.) pods, and evaluated the in vitro antioxidant activity of crude polyphenol fraction (CPP). The total content CPP determined by Folin-Ciocalteu method was 19.2%. condensed tannin vanillin proanthocyanidin assay systems 4.37% 1.36%, respectively. beta-Carotene bleaching, 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging, inhibition lipid peroxidation erythrocyte ghost, microsomal were used to evaluate activity. showed a...
The inhibitor of apoptosis proteins (IAP) regulates cell death by inhibiting caspases. region X-linked (X) IAP containing the second baculovirus repeat domain (BIR2) is sufficient for caspase-3 and -7. In this study, we found that modes inhibition these two caspases were different: inhibited in a competitive manner whereas caspase-7 occurs through mixed noncompetitive mechanism. Binding assays revealed XIAP was totally dependent on interaction between active site linker BIR1 BIR2 domains...
Abstract Background Although mortality associated with pancreatic surgery has decreased dramatically, high morbidity rates are still of major concern. This study aimed to identify the prevalence of, and risk factors for, infectious complications after surgery. Methods The Japanese Society Pancreatic Surgery conducted a multi-institutional analysis in patients who underwent pancreaticoduodenectomy (PD) or distal pancreatectomy (DP) between January 2010 December 2012. Risk that were...
Objective. Despite ongoing research, the clinical and histopathological natural history of immunoglobulin (Ig) G4-related disease (IgG4-RD) remains unclear optimal time to initiate treatment is unknown. A focus on symptoms rather than image finding recommended for therapeutic initiation in autoimmune pancreatitis, but evidence this approach lacking. We aimed retrospectively analyse duration, efficacy with glucocorticoids results examination submandibular gland specimens clarify necessity...
To evaluate the use of fibrin glue sealing pancreatic stump for prevention postoperative fistulas.A prospective, randomized clinical trial.Fibrin is a biologic adhesive consisting highly concentrated human fibrinogen, thrombin, and factor VIII. Twenty-six 56 patients who underwent distal pancreatectomy gastric cancer or disease were randomly assigned to group. Fibrin was applied suture line with ligated main duct. Pancreatic fistula defined as fluid discharge over 7 post-operative days...
Abstract Background Resection of the non-fibrotic pancreas is prone to postoperative pancreatic fistula because well preserved exocrine secretions and easily crushed soft parenchyma. The purpose this study was evaluate ultrasonic dissection for division in distal pancreatectomy. Methods All pancreata included were on direct palpation their main ducts had no dilatation, at least proximally from transection line. Fifty-eight patients with gastric cancer or disease randomly assigned two groups....
Objective: Multiple organ failure because of systemic inflammatory response in the early phase and sepsis late is main contributor to high mortality severe acute pancreatitis (SAP). High-mobility group box chromosomal protein 1 (HMGB1) was recently identified as a potent proinflammatory mediator increases various pathological conditions such sepsis. The aim this study investigate contributions HMGB1 SAP. Methods: We measured serum concentrations by an enzyme-linked immunosorbent assay 45...
Metformin is a commonly used oral anti-hyperglycemic agent of the biguanide family. Recent studies suggest that metformin may reduce cancer risk and improve prognosis. However, antitumor mechanism in several types cancers, including hepatocellular carcinoma (HCC), has not been elucidated. The goal present study was to evaluate effects on HCC cell proliferation vitro vivo, microRNAs (miRNAs) associated with effect vitro. We lines Alex, HLE Huh7, normal hepatocytes human cells. In an vivo...
Background and Objectives Pylorus‐preserving pancreatoduodenectomy (PPPD) has been associated with a high incidence of delayed gastric emptying (DGE). There are few studies comparing DGE PPPD subtotal stomach‐preserving (SSPPD). Moreover, differences between the procedures respect to long‐term results have not reported. A prospective randomized study was conducted compare perioperative complications nutritional status SSPPD. Methods One hundred patients periampullary lesions were receive...
Galectin-9, a soluble β-galactoside-binding animal lectin, evokes apoptosis in various human cancer cell lines. The galectin-9 antitumor effect against hepatocellular carcinoma (HCC) is, however, unknown. We investigated whether suppresses HCC growth vitro and vivo. assessed the of on cells by conducting WST-8 assay xenograft model analysis Galectin-9-induced was evaluated FACS ELISA TUNEL stain Cell cycle alteration profiled FACS. Caspases were colorimetry. MicroRNAs related to effects...
The number of neutrophils in the blood and tissues is controlled by constitutive apoptotic programmed cell death clearance phagocytes such as macrophages. Here, we found that calpains cleave X-linked inhibitor apoptosis (XIAP) vitro, producing fragments are unable to inhibit caspase-3. These were detected normal but unstable rapidly degraded. Calpain inhibition delayed tumor necrosis factor-alpha-induced neutrophils, consistent with a role for regulating onset apoptosis. Interestingly, from...