A5056118777- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease and Transplantation
- Renal cell carcinoma treatment
- Gastrointestinal disorders and treatments
- Liver physiology and pathology
- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Hepatitis B Virus Studies
- Gastric Cancer Management and Outcomes
- Transplantation: Methods and Outcomes
- Cancer, Lipids, and Metabolism
- Pancreatic function and diabetes
- Multiple and Secondary Primary Cancers
- Hepatitis C virus research
- Sarcoma Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Lung Cancer Research Studies
Kobe University
2016-2025
Kobe Medical Center
2025
Hyogo Prefectural Cancer Center
2024
Kobe University Hospital
2013-2024
Komatsu (Japan)
2009-2024
Hyogo Ion Beam Medical Center
2009-2023
National Institute of Diabetes and Digestive and Kidney Diseases
2023
ProQuest (United States)
2023
Kindai University
2015-2022
Aichi Health Promotion Foundation
2022
To quantitatively and noninvasively evaluate common carotid atherosclerosis in a series of patients, we measured the stiffness parameter beta, which represents mechanical properties vessel. beta was calculated from relationship between blood pressure diameter artery as by an ultrasonic, phase-locked, echotracking system. Increases severity grade subsequently determined at autopsy were correlated with increased values 60 arteries (r = .68). Patients greater than 13 had pathological diagnosis...
Abstract BACKGROUND: The objective of this study was to evaluate the clinical outcome proton and carbon ion therapy for hepatocellular carcinoma (HCC). METHODS: In total, 343 consecutive patients with 386 tumors, including 242 (with 278 tumors) who received 101 108 therapy, were treated on 8 different protocols (52.8‐84.0 gray equivalents [GyE] in 4‐38 fractions) 4 (52.8‐76.0 GyE 4‐20 fractions). RESULTS: 5‐year local control overall survival rates all 90.8% 38.2%, respectively. Regarding...
Abstract Background The aim of this study was to determine the added value portal or superior mesenteric vein (PV/SMV) resection during pancreatoduodenectomy for pancreatic head carcinoma. Methods A multicentre observational conducted in patients with carcinoma who underwent seven Japanese hospitals between 2001 and 2012. Clinicopathological factors were compared did not undergo PV/SMV resection. Those an impact on survival identified by univariable multivariable analysis. Results Of 937...
Abstract Background Recent evidence suggests that the presence of microbiome within human pancreatic ductal adenocarcinoma (PDAC) tissue potentially influences cancer progression and prognosis. However, significance tumor-resident remains unclear. We aimed to elucidate impact intratumoral bacteria on pathophysiology prognosis PDAC. Methods The was assessed in 162 surgically resected PDACs using quantitative polymerase chain reaction (qPCR) situ hybridization (ISH) targeting 16S rRNA....
The pathogenesis of hepatitis C virus (HCV) infection is likely to be associated with viral replication in vivo, but little known concerning the dynamics HCV turnover. We performed serial measurements serum HCV-RNA levels following orthotopic liver transplantation (OLT) nine patients HCV-positive cirrhosis. Serum were determined by quantitative polymerase chain reaction before, immediately after, and for up 1 month after OLT. There was a rapid decline from 3.1 +/- 1.3 x 10(5) copies/ mL...
Pancreatogenic diabetes after pancreatectomy is of growing importance due to the increasing life expectancy pancreatectomized patients. Although reduction pancreatic volume thought affect glucose metabolism, a consistent relationship has yet be determined. This study aimed investigate functional consequences distal (DP) in preoperatively non-diabetic
Background and Objectives Pylorus‐preserving pancreatoduodenectomy (PPPD) has been associated with a high incidence of delayed gastric emptying (DGE). There are few studies comparing DGE PPPD subtotal stomach‐preserving (SSPPD). Moreover, differences between the procedures respect to long‐term results have not reported. A prospective randomized study was conducted compare perioperative complications nutritional status SSPPD. Methods One hundred patients periampullary lesions were receive...
Carbohydrate antigen (CA) 19–9 levels after resection are considered to predict prognosis; however, the significance of decreased CA19–9 neoadjuvant therapy has not been clarified. This study aimed define prognostic in patients with pancreatic adenocarcinoma. Between 2001 and 2012, 240 consecutive received subsequent at seven high-volume institutions Japan. These were divided into three groups: Normal group (no elevation [≤37 U/ml] before therapy), Responder (elevated [> 37 but afterwards),...
Abstract This study aimed to evaluate the efficacy of stereotactic body radiotherapy (SBRT) compared with three-dimensional conformal (3DCRT). Forty-three patients portal vein tumor thrombosis (PVTT)/inferior vena cava (IVCTT) treated SBRT (27 CyberKnife (CK) and 16 TrueBeam (TB)) from April 2013 December 2014, 54 3DCRT June 2008 March were evaluated. Dosimetric parameters, response (RT) survival outcomes in total vs. 3DCRT, CK TB respectively. The median biologically effective dose 10...
The prevalent location and incidence of intraductal papillary neoplasm the bile duct (IPNB) invasive carcinoma associated with them have varied markedly among studies due to differences in diagnostic criteria tumor location.IPNBs were classified into two types: Type 1 IPNB, being histologically similar mucinous pancreas, 2 having a more complex histological architecture irregular branching or foci solid-tubular components. Medical data evaluated.Among 694 IPNB patients, 520 174 had 2,...
For the 23rd Nationwide Follow-up Survey of Primary Liver Cancer in Japan, data from 20 889 newly registered patients and 42 274 previously follow-up were compiled 516 institutions over a 2-year period January 1, 2014 to December 31, 2015. Basic statistics for survey cause death, past medical history, clinical diagnosis, imaging treatment-related factors, pathological recurrence status, autopsy findings. Compared with previous 22nd survey, population hepatocellular carcinoma (HCC) was older...
The excess mortality of coronavirus disease 2019 (COVID-19) solid organ transplant recipients (SOTRs) throughout the pandemic remains unclear. This prospective cohort study based on Japanese nationwide registry included 1632 SOTRs diagnosed with COVID-19 between February 1, 2020, and July 31, 2022, categorized dominant phases variants concern (VOCs): Waves 1 to 3 (Beta), 4 (Alpha), 5 (Delta), 6 (Omicron BA.1/BA.2), 7 BA.5). Excess COVID-19-affected was analyzed by calculating standardized...
The aim of this study was to achieve a better definition intraductal papillary neoplasms the bile duct (IPNBs).Biliary tumours that showed predominantly growth were provisionally classified as IPNBs (n = 25) and cholangiocarcinomas 27). IPNB defined neoplasm is confined epithelium or regularly arranged in high-papillary architecture along thin fibrovascular stalks, whereas term 'papillary cholangiocarcinoma' used for with more complex structures (e.g. irregular branching mixed solid-tubular...
To identify optimal surgical methods and the risk factors for long-term survival in patients with hepatocellular carcinoma accompanied by macroscopic bile duct tumor thrombus (BDTT).Prognoses of BDTT have been known to be poor. There significant controversies regarding approaches because low incidence small number cases previous reports.Records 257 from 32 centers Korea Japan (1992-2014) were analyzed overall recurrence rate using Cox proportional hazard model.Curative surgery was performed...
This study aimed to elucidate the genetic landscape of biliary papillary neoplasms. Of 28 cases examined, 7 underwent whole exome sequencing, while remaining 21 were used for validation studies with targeted sequencing. In sequencing study, 4/7 had mutations in either APC or CTNNB1 , both which belong Wnt/β-catenin pathway. Somatic also identified genes involved RAS signaling ( KRAS BRAF ), a cell cycle regulator CDC27 histone methyltransferase KMT2C KMT2D and DNA mismatch repair MSH3 MSH6...
The optimal therapeutic strategy for very elderly pancreatic cancer patients remains to be determined. aim of this study was clarify the role resection in 80 years age or older.A retrospective multicenter analysis 1401 who had undergone performed. aged ≥ (n = 99) were compared with a control group <80 1302).There no significant differences postoperative complications and mortality between two groups. However, prognosis octogenarians poorer than that younger both resectable borderline tumors....