A5003694957- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Esophageal and GI Pathology
- Metastasis and carcinoma case studies
- Gastrointestinal disorders and treatments
- Esophageal Cancer Research and Treatment
- Gastrointestinal Bleeding Diagnosis and Treatment
- Minimally Invasive Surgical Techniques
- Gastroesophageal reflux and treatments
- Colorectal Cancer Screening and Detection
- Neuroendocrine Tumor Research Advances
- Infection Control and Ventilation
- COVID-19 and healthcare impacts
- Cervical Cancer and HPV Research
- Gallbladder and Bile Duct Disorders
- Helicobacter pylori-related gastroenterology studies
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Surgical Treatments
- Metabolism, Diabetes, and Cancer
- Clinical Nutrition and Gastroenterology
- Endometrial and Cervical Cancer Treatments
- Eosinophilic Esophagitis
- Dysphagia Assessment and Management
- Cancer, Hypoxia, and Metabolism
- Diverticular Disease and Complications
Kagawa University
2015-2024
Kagawa University Hospital
2022
Sakai Municipal Hospital
2017-2020
Shujitsu University
2020
Takamatsu University
2018
University of Kochi
2017
Ehime Medical Center
2016-2017
Creative Research Enterprises (United States)
2016
Kio University
2016
Kyoto Institute of Technology
2016
To retrospectively review the results of over-the-scope clip (OTSC) use in our hospital and to examine feasibility using OTSC treat perforations after endoscopic submucosal dissection (ESD).We enrolled 23 patients who presented with gastrointestinal (GI) bleeding, fistulae were treated OTSCs (Ovesco Endoscopy GmbH, Tuebingen, Germany) between November 2011 September 2012. Maximum lesion size was defined as diameter. The number be used per patient not decided until completely closed. We a...
Although several methods to create an effective counter traction for safer endoscopic submucosal dissection (ESD) have been reported, these do not overcome problems regarding delivery and ease of use. This randomized prospective study assessed the usefulness ring-shaped thread traction, which only allowed colorectal ESD but also easiest lower cost without any special devices. Forty-five patients diagnosed with lateral spreading tumors over 20 mm were allocated conventional group (CE) (n =...
Recently, various types of cultured cells have been used to research the mechanisms transport and metabolism drugs. Although many studies using cell systems published, a comparison different has never reported. In this study, Caco-2, Calu-3, Madin–Darby canine kidney (MDCK), EpiAirway MucilAir were as popular in vitro culture systems, permeability model compounds across these was evaluated compare barrier characteristics clarify their usefulness an estimation system for nasal drug absorption...
Endoscopic closure of post-endoscopic submucosal dissection (ESD) defects can reduce postoperative adverse events [1]. Innovative techniques such as use an endoloop [2], endoscopic ligation with O-ring [3], and reopenable clip over the line method [4] have recently been developed; however, complexity time-consuming nature procedures remain problematic. We introduce a strategy using new endoclip mantis-like claw (MANTIS Clip; Boston Scientific, Marlborough, Massachusetts, USA) ([Fig. 1]) that...
Recent studies suggest that metformin, which is a member of the biguanide family and commonly used as an oral anti-hyperglycemic agent, may reduce cancer risk improve prognosis numerous types cancer. However, mechanisms underlying antitumor effect metformin on esophageal remain unknown. The goal present study was to evaluate effects proliferation human ESCC in vitro, changes expression profile microRNAs (miRNAs), since miRNAs have previously been associated with other cancers. cell lines...
Closure of post‐endoscopic submucosal dissection ( ESD ) duodenal artificial ulcer is not common in the clinical setting. We consider that post‐ closure by an over‐the‐scope‐clip OTSC method one most effective ways to prevent delayed perforation. report here two cases mucosal cancer a 65‐year‐old woman and 78‐year‐old man. Pathological examinations resected specimens revealed well‐differentiated adenocarcinomas. In these cases, we successfully carried out complete closures using without any...
Esophageal carcinoma is the eighth most common cancer worldwide and sixth leading cause of cancer-related deaths, with one worst prognoses any form cancer. Treatment anti-diabetic drug metformin has been associated reduced incidence in patients type 2 diabetes. This study therefore evaluated effects on proliferation, vitro vivo, human esophageal adenocarcinoma cells, as well microRNAs antitumor metformin. Metformin inhibited proliferation cell lines OE19, OE33, SK-GT4 OACM 5.1C, blocking G0...
AIMTo demonstrate the clinical outcomes of a multicenter experience and to suggest guidelines for choosing suction method. METHODSThis retrospective study at 5 medical centers involved 58 consecutive patients undergoing over-the-scope clips (OTSCs) placement.The overall rates technical success (TSR), (CSR), complications, procedure time were analyzed as major outcomes.Subsequently, 56 patients, excluding two cases that used Anchor device, divided into groups: 14 simple (SS-group) 42 using...
Esophageal squamous cell carcinoma (ESCC) is the most common primary esophageal malignancy. Telmisartan, an angiotensin II type 1 (AT1) receptor blocker (ARB) and a widely used antihypertensive, has been shown to inhibit proliferation of various cancer types. This study evaluated effects telmisartan on human ESCC in vitro vivo sought identify microRNAs (miRNAs) involved these antitumor effects. We examined three lines (KYSE150, KYSE180, KYSE850). Telmisartan inhibited by inducing S-phase...
Local steroid injection therapy is effective for preventing esophageal stricture after endoscopic submucosal dissection (ESD) but associated with the risk of puncture-related complications, such as bleeding. We evaluated effectiveness application triamcinolone acetonide gel following permeation into a large artificial ESD ulcer by balloon dilatation compared injection.Forty-three patients who underwent early cancer approved institutional ethics committee and provided consent to participate...
Hepatocellular carcinoma (HCC) is one of the major causes cancer-related deaths worldwide. Sorafenib has been used as a first-line systemic treatment for over decade. However, resistance to sorafenib limits patient response and presents hurdle during HCC treatment. Lenvatinib approved advanced first agent achieve non-inferiority against sorafenib. Therefore, in present study, we evaluated inhibition efficacy lenvatinib sorafenib-resistant cells. Only few studies have conducted on this topic....
Abstract Background We examined the efficacy of a novel endoscopic ligation technique with O-ring closure (E-LOC) to prevent bleeding after gastric submucosal dissection (ESD) under antithrombotic therapy. Methods This single-center prospective study involved consecutive patients who were taking agents and underwent ESD. E-LOC was performed by anchoring nylon loop hemoclips on both defect edges and/or exposed muscle layer, using band around these deployed clips. The primary outcome post-ESD...
Galectin-9 (Gal-9) enhances tumor immunity mediated by T cells, macrophages, and dendritic cells. Its expression level in various cancers correlates with prognosis. Furthermore, Gal-9 directly induces apoptosis cancers; however, its mechanism of action bioactivity has not been clarified. We evaluated antitumor effect against esophageal squamous cell carcinoma (ESCC) to analyze the dynamics apoptosis-related molecules, elucidate action, identify relevant changes miRNA expressions. KYSE-150...
The recently developed endoscopic full-thickness resection technique requires reliable closure. main closure methods are the purse-string suture (PSS) and over-the-scope clip (OTSC) technique; however, basic data on strength of each lacking. This study was performed to compare strengths these two in an ex vivo porcine model.
Metabolic syndrome is a cluster of metabolic abnormalities and defined as the presence three or more following factors: increased waist circumference, elevated triglycerides, low high-density lipoprotein cholesterol, high blood pressure, fasting glucose. Obesity, which accompanied by dysregulation often manifested in syndrome, an established risk factor for many cancers. Adipose tissue, particularly visceral fat, important tissue it secretes systemic factors that alter immunologic,...
<b>Background and study aims:</b> Endoscopic submucosal dissection (ESD) of large gastric lesions results in an extensive artificial ulcer that can lead to marked deformity. The aim the current was evaluate therapeutic efficacy prevention deformity local triamcinolone acetonide (TCA) injection into following ESD. <b>Patients methods:</b> A total 45 patients who were diagnosed with early cancer enrolled. Patients randomly assigned by sealed-envelope randomization method either TCA injections...