A5069866009- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Drug Solubulity and Delivery Systems
- Drug Transport and Resistance Mechanisms
- Bone health and treatments
- RNA Interference and Gene Delivery
- Dendrimers and Hyperbranched Polymers
- Dermatology and Skin Diseases
- Pharmacological Effects and Toxicity Studies
- Nitric Oxide and Endothelin Effects
- Biochemical Analysis and Sensing Techniques
- Clusterin in disease pathology
- Radiopharmaceutical Chemistry and Applications
- Extracellular vesicles in disease
- Cancer, Lipids, and Metabolism
- Nanoparticle-Based Drug Delivery
- Analytical Methods in Pharmaceuticals
- Lipid Membrane Structure and Behavior
- Sulfur Compounds in Biology
- Curcumin's Biomedical Applications
- Amino Acid Enzymes and Metabolism
- Inhalation and Respiratory Drug Delivery
- Hemoglobin structure and function
- Bone and Joint Diseases
- Galectins and Cancer Biology
Osaka Ohtani University
2025
Kyoto Pharmaceutical University
2015-2024
University of British Columbia
2015
Kyoto College of Medical Science
2014
In-Q-Tel
2014
Kyoto University
2004-2010
Shujitsu University
2010
Setsunan University
2010
Oxytocin (OXT) is a cyclic nonapeptide, two amino acids of which are cysteine, forming an intramolecular disulfide bond. OXT produced in the hypothalamus and secreted into bloodstream from posterior pituitary. As recent studies have suggested that neurotransmitter exhibiting central effects important for social deficits, it has drawn much attention as drug candidate treatment autism. Although human-stage clinical trials nasal spray autism already begun, few examined pharmacokinetics brain...
Extracellular vesicles (EVs) secreted from probiotics, defined as live microorganisms with beneficial effects on the host, are expected to be new nanomaterials for EV-based therapy. To clarify usability of probiotic-derived EVs in terms therapy, we systematically evaluated their characteristics, including yield, physicochemical properties, cellular uptake mechanism, and biological functions, using three different types probiotics: Bifidobacterium longum, Clostridium butyricum, Lactobacillus...
Effects of Labrasol and other pharmaceutical excipients on the intestinal transport absorption rhodamine123, a P-glycoprotein substrate (P-gp) were examined. Intestinal studies examined by an in vitro diffusion chamber method situ closed loop method. We evaluated membrane damage produced measuring release protein alkaline phosphatase (ALP). (0.075—0.1% (v/v)) increased absorptive rhodamine123 decreased its secretory studies. However, did not change Lucifer yellow, non-P-gp substrate,...
Lipid nanoparticle (LNP) formulations facilitate tumor uptake and intracellular processing through an enhanced permeation retention effect (EPR), currently multiple products are undergoing clinical evaluation. Clusterin (CLU) is a cytoprotective chaperone induced by androgen receptor (AR) pathway inhibition to adaptive survival signaling treatment resistance. In our study, we investigated the efficacy of siRNA delivery using LNP systems in enzalutamide-resistant (ENZ-R) castration-resistant...
Recently, various types of cultured cells have been used to research the mechanisms transport and metabolism drugs. Although many studies using cell systems published, a comparison different has never reported. In this study, Caco-2, Calu-3, Madin–Darby canine kidney (MDCK), EpiAirway MucilAir were as popular in vitro culture systems, permeability model compounds across these was evaluated compare barrier characteristics clarify their usefulness an estimation system for nasal drug absorption...
Effective delivery of drug carriers selectively to the kidney is challenging because their uptake by reticuloendothelial system in liver and spleen, which limits effective treatment diseases results side effects. To address this issue, we synthesized l-serine (Ser)-modified polyamidoamine dendrimer (PAMAM) as a potent renal targeting carrier. Approximately 82% dose was accumulated at 3 h after i.v. injection 111In-labeled Ser-PAMAM mice, while unmodified PAMAM, l-threonine modified...
Brain tumors are one of the most lethal and difficult to treat. Their treatment is limited by inadequate delivery antitumor drugs tumor. In order overcome this limitation, possibility nose-brain direct transport pathway was evaluated using methotrexate (MTX) as a model agent. The nasal MTX cerebrospinal fluid (CSF) examined comparing concentration in plasma CSF after intraperitoneal (IP) intranasal (IN) administrations. brain uptake based on multiple-time/graphical analysis measuring brain....
The purpose of this study was to evaluate the characteristics exendin-4 tip-loaded microneedle arrays and compare their acute efficacy with subcutaneous injections in type 2 diabetic GK/Slc rats. Fluorescein isothiocyanate labeled dextran an average molecular weight 4,000 (FD4) selected as a model drug, FD4 were prepared study. In addition, intraperitoneal glucose tolerance tests after application also compared those injection release from very rapid, particularly initial 30 s, most released...
Reactive oxygen species (ROS) are involved in the pathophysiology of ischemia/reperfusion injury. To protect mouse hepatocytes from injury, we prepared two different sizes citric acid-protected platinum nanoparticles (Pt-NPs), which exhibited ROS-scavenging activities and selective delivery to a specific type liver cell. Small Pt-NPs (30 nm) reduced superoxide anion, hydrogen peroxide, hydroxyl radical levels solution greater extent than did large (106 nm). Large small predominantly...
Human parathyroid hormone (1-34) (PTH) has been widely used as the subcutaneous injection formulation for treatment of osteoporosis. In present study, we developed an efficient transdermal delivery system PTH by using dissolving microneedle arrays (MNs) composed hyaluronic acid (HA) PTH-loaded MNs, with needle length 800 µm, were fabricated via a micro-molding method. The stability in MNs was found to be 6-fold higher than that solution when stored at room temperature (15⁻20 °C) one month....
Interferon alpha (IFNα) is one of the most famous drugs for treatment chronic hepatitis C and various types human malignancy. Protein drugs, including IFNα, are generally administered by subcutaneous or intramuscular injection due to their poor permeability low stability in bloodstream gastrointestinal tract. Therefore, present study, novel IFNα-coated polyvinyl alcohol-based microneedle arrays (IFNα-MNs) were fabricated transdermal delivery IFNα without painful injection. was rapidly...
The purpose of the present study was to develop an alternative transdermal formulation containing sumatriptan succinate (SS) for treatment migraine. Novel self-dissolving SS-loaded microneedle arrays (MNs) were fabricated from sodium hyaluronate and their efficacy delivery SS characterized. resulting MNs maintained skin piercing abilities at least 30 min after being placed a high relative humidity 75%. Rapid release also observed in vitro. Optical coherence tomography images demonstrated...