A5023435471- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Organ Transplantation Techniques and Outcomes
- Metastasis and carcinoma case studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease and Transplantation
- Cardiac Ischemia and Reperfusion
- Pediatric Hepatobiliary Diseases and Treatments
- Neuroendocrine Tumor Research Advances
- Gallbladder and Bile Duct Disorders
- Cancer, Hypoxia, and Metabolism
- Photodynamic Therapy Research Studies
- Immune Response and Inflammation
- Gastrointestinal disorders and treatments
- Pancreatitis Pathology and Treatment
- Medical Imaging Techniques and Applications
- Metabolism, Diabetes, and Cancer
- Pharmacogenetics and Drug Metabolism
- Advanced Glycation End Products research
- Radiomics and Machine Learning in Medical Imaging
- Inflammatory mediators and NSAID effects
- Infrared Thermography in Medicine
National Hospital Organization Takamatsu Medical Center
2010-2016
Kagawa University
2005-2014
American Gastroenterological Association
2009
Biogipuzkoa Health Research Institute
2008
University of Pittsburgh
2005-2006
University of Pittsburgh Medical Center
2006
Laboratory Imaging (Czechia)
2005
American Society of Echocardiography
2005
Kagawa University Hospital
2004
National Cancer Center Hospital East
1997-2003
Endogenous ligands from damaged cells, so-called damage-associated molecular pattern molecules, can activate innate immunity via TLR4 signaling. Hepatic warm ischemia and reperfusion (I/R) injury inflammation is largely dependent. We produced chimeric mice to assess whether the TLR4-dependent required expression on liver parenchymal or nonparenchymal cells. Chimeric were by adoptive transfer of donor bone marrow cells into irradiated recipient animals using reciprocal combinations wild-type...
Abstract High mobility group box 1 (HMGB1) is a NF released extracellularly as late mediator of lethality in sepsis and an early inflammation following injury. Here we demonstrate that contrast to the proinflammatory role HMGB1, preconditioning with HMGB1 results protection hepatic ischemia/reperfusion (I/R). Pretreatment mice significantly decreased liver damage after I/R. The observed pretreated was associated higher expression IL-1R-associated kinase-M, negative regulator TLR4 signaling,...
Abstract Endogenous ligands released from damaged cells, so-called damage-associated molecular pattern molecules (DAMPs), activate innate signaling pathways including the TLRs. We have shown that hepatic, warm ischemia and reperfusion (I/R) injury, generating local, noninfectious DAMPs, promotes inflammation, which is largely TLR4-dependent. Here, we demonstrate increasing dendritic cell (DC) numbers enhance inflammation organ injury after hepatic I/R. High-mobility group box 1 (HMGB1), a NF...
Hypoxia is a critical event for higher organisms, and cells tissues react by increasing the oxygen supply vasodilatation, angiogenesis, erythropoiesis maintaining cellular energy glycolysis inhibiting anabolic pathways. Stimulation of has been regarded as main response that increases production during hypoxia; however, there an obvious conflict ischemia, because both glucose are insufficient. In this study, we found exposure HepG2 normal fibroblasts to hypoxia induces tolerance starvation....
AIM:To evaluate the role of positron emission tomography using 18F-fluorodeoxyglucose (FDG-PET) in surgical management patients with pancreatic cancer, including diagnosis, staging, and selection for subsequent treatment. METHODS:This study involved 53 proven primary cancer.The sensitivity diagnosing cancer was examined FDG-PET, CT, cytological examination bile or juice, serum levels carcinoembrionic antigens (CEA) carbohydrate antigen 19-9 (CA19-9).Next, accuracy staging compared between...
Hepatic ischemia occurs in the settings of trauma, transplantation, and elective liver resections. The initiating events that account for local organ damage are only partially understood. Interferon (IFN) regulatory factor-1 (IRF-1) is a transcription factor regulates expression number genes involved both innate acquired immunity; however, its function injury unknown. Therefore, purpose this study was to investigate role IRF-1 hepatic ischemia-reperfusion (I/R) injury. In C57BL/6 mice...
The reason for the difference in fluorescence between normal and diseased tissues (carcinoma adenoma) colon observed on autofluorescence endoscopy is unclear, flavins, NADPH collagen being regarded as possible major sources of fluorescence. purpose this study was to identify fluorescence.Samples human colonic (adenoma: n = 6, cancer: 11, normal: 11) were obtained from resected specimens. flavin content tissue measured by high performance liquid chromatography. Fluorescence microscopy under...
The impact of the use preoperative portal vein embolization (PVE) on long-term survival after surgery was evaluated by retrospective analysis prognostic factors in patients with advanced-stage hepatocellular carcinoma (HCC) who had undergone hepatic resection or without PVE.The group (Group P) consisted 26 major hepatectomy (more extensive than right hepatectomy) PVE, and nonembolized N) 43 PVE. All were diagnosed advanced HCC graded as Stage III IV according to International Union Against...
Tumor infiltrating lymphocytes (TILs) have been recognized as a tumor-host reaction in various primary neoplasms. Although several studies reported TILs surrounding metastatic liver tumors, to the authors' knowledge few evaluations of clinical significance such features patients with colorectal metastases carried out.Forty-one who underwent initial hepatic resection for from cancer were studied. Lymphocytic infiltration tumor was graded weak or dense according mean number 10 high-power...
Abstract Background Chemoresistance is a serious problem in pancreatic cancer, but the mechanism of resistance and strategies against have not been elucidated. We examined potential phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor LY294002 to enhance anti-tumor effect cisplatin investigated chemoresistance cancer cells using combination therapy LY294002, both vitro vivo . Methods Cisplatin individually or combination, were given AsPC-1 PANC-1 cell lines. Tumor growth, DNA fragments, Akt...
Abstract Background The use of [18F] 2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) for detection gastric cancer is often debated because FDG uptake varies each patient. purpose this study was to clarify the molecular mechanisms involved in uptake. Material and methods Fifty patients with who underwent FDG-PET gastrectomy were studied. Snap-frozen tumor specimens collected examined by real-time PCR relationships between maximum standardized value (SUV) mRNA expression...
Hepatic ischemia-reperfusion (I/R) injury occurs in the settings of transplantation, trauma, and elective liver resection. Ischemic preconditioning has been used as a strategy to reduce inflammation organ damage from I/R liver. However, mechanisms involved this process are poorly understood. We examined role phosphatidylinositol 3 (PI3) kinase/Akt-signaling pathway during hepatic ischemic (IPC). Prior prolonged warm insult, BALB/c mice were subjected 20-minute IPC period consisting 10...
Recent studies suggest that small non‑coding microRNAs (miRNAs or miRs) play an important role in the regulation of genes involved various cellular and developmental processes. However, expression miRNAs during aging process remains largely unknown. The aim present study was to analyze miRNA profiles rat livers process. male Wistar rats at different stages development (fetal, aged 3 days, 1, 2, 4, 8 36 weeks age) were used. Total RNA extracted from livers. We analyzed levels 679 probes. In...
Cyclins, cyclin-dependent kinases (Cdks), and Cdk inhibitors (CdkIs) are frequently altered in human cancer. p18 INK4C , a member of the INK4 family CdkIs, is potential tumor-suppressor gene product. However, expression hepatocellular carcinoma (HCC) remains unknown. The aim this study was to examine various liver diseases including HCC assess its clinical significance HCC. To that end, we examined by immunohistochemistry diseases, 51 HCCs, also studied relationship between expression,...