A5004575423- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Gastrointestinal disorders and treatments
- Colorectal Cancer Screening and Detection
- Pancreatic and Hepatic Oncology Research
- Gastroesophageal reflux and treatments
- Atomic and Molecular Physics
- Gastrointestinal Bleeding Diagnosis and Treatment
- Minimally Invasive Surgical Techniques
- Scientific Measurement and Uncertainty Evaluation
- Gallbladder and Bile Duct Disorders
- Mass Spectrometry Techniques and Applications
- Advanced Chemical Physics Studies
- Dysphagia Assessment and Management
- Ion-surface interactions and analysis
- Diet and metabolism studies
- Vitamin K Research Studies
- Synthesis of Organic Compounds
- Orthopaedic implants and arthroplasty
- Nuclear Physics and Applications
- Colorectal Cancer Surgical Treatments
- Quantum, superfluid, helium dynamics
Tokyo Metropolitan University
1981-2024
Kagawa University
2015-2023
Kagawa University Hospital
2022
Ehime Medical Center
2016
Southern Tohoku General Hospital
2012
Ophthalmology Clinic
2012
Niigata University
2009
The University of Tokyo
1996
Esophageal squamous cell carcinoma (ESCC) is the most common primary esophageal malignancy. Telmisartan, an angiotensin II type 1 (AT1) receptor blocker (ARB) and a widely used antihypertensive, has been shown to inhibit proliferation of various cancer types. This study evaluated effects telmisartan on human ESCC in vitro vivo sought identify microRNAs (miRNAs) involved these antitumor effects. We examined three lines (KYSE150, KYSE180, KYSE850). Telmisartan inhibited by inducing S-phase...
Abstract Background We examined the efficacy of a novel endoscopic ligation technique with O-ring closure (E-LOC) to prevent bleeding after gastric submucosal dissection (ESD) under antithrombotic therapy. Methods This single-center prospective study involved consecutive patients who were taking agents and underwent ESD. E-LOC was performed by anchoring nylon loop hemoclips on both defect edges and/or exposed muscle layer, using band around these deployed clips. The primary outcome post-ESD...
Galectin-9 (Gal-9) enhances tumor immunity mediated by T cells, macrophages, and dendritic cells. Its expression level in various cancers correlates with prognosis. Furthermore, Gal-9 directly induces apoptosis cancers; however, its mechanism of action bioactivity has not been clarified. We evaluated antitumor effect against esophageal squamous cell carcinoma (ESCC) to analyze the dynamics apoptosis-related molecules, elucidate action, identify relevant changes miRNA expressions. KYSE-150...
The recently developed endoscopic full-thickness resection technique requires reliable closure. main closure methods are the purse-string suture (PSS) and over-the-scope clip (OTSC) technique; however, basic data on strength of each lacking. This study was performed to compare strengths these two in an ex vivo porcine model.
Abstract Background and study aims Endoscopic ultrasound-guided fine needle aspiration (FNA) for gastrointestinal subepithelial lesions (SELs) has limited diagnostic accuracy due to technical problems small lesion size. We previously reported a novel submucosal tunneling biopsy (STB) technique sampling SELs. This aimed evaluate the ability safety of STB compared that FNA Patients methods The was non-randomized, prospective comparative with crossover design in patients endoluminal gastric...
Endoscopic closure of a gastrointestinal artificial defect effectively reduces the incidence postoperative adverse events [1], especially delayed bleeding due to antithrombotic drugs. However, although several techniques have been developed, including endoloop [2], multiple clip-and-line [3], and hand suturing [4], there is still no convenient reliable technique for stomach because thick gastric wall. One important issue that limited mucosal results in formation bridge cavity, leading...
Abstract Background and study aims Exposed endoscopic full-thickness resection (EFTR) enables the operator to obtain a sufficient surgical margin. However, insufflation leakage secure closure (EFTC) remain problematic. This aimed evaluate safety feasibility of new exposed EFTR. Patients methods EFTR was performed for 2-cm virtual lesions in different locations upper stomach four dogs. mainly involved half-circumferential endpoint clip-line traction. Pulley traction applied with forward...
To evaluate the efficacy and safety of a grasping-type knife, called Clutch Cutter (CC), for colorectal endoscopic submucosal dissection (C-ESD). This was randomized prospective study. Patients who underwent C-ESD neoplasms >20 mm <50 in size were enrolled, dividing into two groups: ESD using needle type dual knife alone (D-group) circumferential incision followed by CC (CC-group). The primary outcome self-completion rate. secondary outcomes intraoperative complication rate, procedure time,...
Narrow band imaging with magnifying endoscopy (NBI-ME), which is useful for the assessment of micro-vessels, has excellent diagnostic potential early gastrointestinal epithelial neoplasia. Conventional tools uterine cervical tumors are still unsatisfactory. An accurate tool required to preserve reproductive ability young women tumors. Flexible NBI-ME was performed in patients squamous cell lesions that further examinations based on their Pap smear results (cytology ≥ low-grade...
The ion mobilities of N2+ and CO+ in He have been measured using a liquid-helium-cooled, selected drift tube at 4.35 K. Mobility reaches maximum an effective temperature between 400 K 600 K, where it is reasonable agreement with the room measurements other experimenters. Below 100 there region which are constant, close to polarization limit somewhat lower, possibly due occurrence collisionally induced, rotational excitation. At very low though, below 10 decrease sharply, limit. This may be...
Background and Aims: Endoscopic submucosal dissection (ESD) seems to be a reasonable option for gastrointestinal subepithelial lesions (SELs) localized within the submucosa. Indications ESD include small neuroendocrine tumors (NETs) indeterminate SELs. However, prospective data regarding surveillance remain unclear. This study was performed prospectively investigate outcomes of ESD, including organ-specific mid-term prognosis.
 Methods: multicenter included 57 patients who underwent...
Cross sections for single and multiple electron capture in collisions of C4+ with H2, N2 O2 have been measured within the energy range 0.33-666 eV amu-1. Where comparison is possible, results are good agreement previous measurements at higher energies. Below 100 amu-1 there significant differences between experiment currently available theories.
Although there have been several reports of treating large post-endoscopic submucosal dissection (ESD) ulcers by covering them with a polyglycolic acid sheet (PGAs), this approach presents problems regarding PGAs delivery. This study assessed the usefulness device delivery station system (DDSS) to evaluate appropriate and rapid coating method DDSS. Thirty-nine 41 patients who were diagnosed early gastric cancer over 20 mm in diameter pathologically well-differentiated adenocarcinoma randomly...
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal of digestive tract. The angiotensin II type 1 receptor blockers, telmisartan and candesartan, widely used antihypertensive drugs that inhibits cancer cell proliferation; however, its underlying mechanisms in tumors, including GIST, remains unknown. present study aimed to investigate effect on GIST‑T1 cells mechanism. Telmisartan candesartan inhibited proliferation these by blocking G0 G1 cycle transition, which was...
Although several reports have suggested that the inflammation after endoscopic submucosal dissection (ESD) of colon can be reduced by closure ulcer [1] [2], a simpler and more reliable has not been reported for ulcers over 6 cm in diameter.
Small bowel adenocarcinoma (SBAC) accounts for 3% of all gastrointestinal tract tumors and approximately 0.5% cancer cases. Recent studies have indicated that the use metformin, one most commonly prescribed antidiabetic drugs, is associated with a better prognosis certain malignant diseases. However, there been no reports on effect metformin in SBAC. In present study, we evaluated human SBAC cell proliferation vitro vivo identified microRNAs (miRNAs) its antitumor effects. Metformin...
The Over-The-Scope Clip (OTSC) can effectively treat refractory gastrointestinal diseases. However, most reports have focused on short-term effectiveness. We examined clinical outcomes of the deployed clips and long-term characteristics.Of 47 patients with OTSC treatment, 35 follow-up periods ≥3 months were retrospectively examined. indications 11 bleedings, 17 perforations, seven fistulas. observation period was defined as medium-term (3 to <12 months) or (≥12 months). primary outcome...
Although endoscopic submucosal dissection (ESD) is well established, cases with ulcer scars are challenging. full-thickness resection (EFTR) may become a safe method for risky ESD, there problems such as cancer dissemination (Video 1, available online at www.giejournal.org). To overcome these problems, we developed non-exposed EFTR 2, www.giejournal.org), in which used suturing device: the double-armed bar system (DBSS) (Zeon Medical Co., Tokyo, Japan) (Fig. 1A, Video 3, A 14-month-old...
No protocol for esophagogastroduodenoscopic examination of the duodenum has been established. We examined feasibility and ability to detect neoplasms a novel duodenal protocol.
Duodenal endoscopic submucosal dissection (ESD) is associated with high incidences of intraoperative complications and delayed adverse events (AEs). Delayed AEs can be reduced by closing the post-ESD defects. We developed a new method closure after duodenal ESD, combining ligation O-ring (E-LOC) an over-the-scope clip (OTSC) (Band OTSC; B-OTSC). Here, we conducted single-center, retrospective, observational study to investigate efficacy safety B-OTSC for preventing in patients undergoing...
With an ion energy-loss spectrometer, of which ultimate energy resolution was improved to be as good 7.0 meV (FWHM), rotational excitation H2 molecules by Li+ impact studied. Above 150 eV, occurs in strongly forward scattering and integral cross sections could determined from the spectra obtained at a angle 0 degrees . The for transitions, J=0 2, 1 3, 2 4, 3 5, 0, 1, 5 were determined. with Delta J=2 transitions are magnitude 10-16 cm2 section J=4 transition is about two orders smaller than...