A5042537578- MicroRNA in disease regulation
- Neurological diseases and metabolism
- Ion Transport and Channel Regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Gastrointestinal Tumor Research and Treatment
- Cancer-related molecular mechanisms research
- Mitochondrial Function and Pathology
- Porphyrin Metabolism and Disorders
- Metastasis and carcinoma case studies
- Diabetes Treatment and Management
- Cannabis and Cannabinoid Research
- Gastrointestinal motility and disorders
- RNA regulation and disease
- Prion Diseases and Protein Misfolding
- Alzheimer's disease research and treatments
- Circular RNAs in diseases
- Neuroscience and Neuropharmacology Research
- Neurological Disease Mechanisms and Treatments
- Gastric Cancer Management and Outcomes
- Amino Acid Enzymes and Metabolism
- Cerebrospinal fluid and hydrocephalus
- Metabolism and Genetic Disorders
- Cancer, Hypoxia, and Metabolism
- Intracerebral and Subarachnoid Hemorrhage Research
Kagawa University
2020-2024
Kagawa University Hospital
2020
Diabetes mellitus (DM) is now recognized as one of the risk factors for Alzheimer's disease (AD), and disease‐modifying effects anti‐diabetic drugs on AD have recently been attracting great attention. Sodium/glucose cotransporter 2 (SGLT2) inhibitors are a new class targeting SGLT2/solute carrier family 5 member (SLC5A2) protein, which known to localize exclusively in brush border membrane early proximal tubules kidney. However, recent data suggest that it also expressed other tissues. In...
Progressive supranuclear palsy (PSP) is a neurodegenerative tauopathy described as syndrome of postural instability, vertical gaze palsy, dysarthria, dystonic rigidity the neck and trunk, dementia, pseudobulbar palsy. The clinical diagnosis PSP often difficult because there are no established biomarkers, currently based on imaging findings. Furthermore, etiology pathogenesis remain unknown. Dysregulation microRNAs (miRNAs/miRs) has been reported to serve an important role in diseases....
To evaluate the efficacy and safety of a grasping-type knife, called Clutch Cutter (CC), for colorectal endoscopic submucosal dissection (C-ESD). This was randomized prospective study. Patients who underwent C-ESD neoplasms >20 mm <50 in size were enrolled, dividing into two groups: ESD using needle type dual knife alone (D-group) circumferential incision followed by CC (CC-group). The primary outcome self-completion rate. secondary outcomes intraoperative complication rate, procedure time,...
A 63-year-old woman who presented for orofacial dystonia showed cortical ribboning, a typical MRI finding in sporadic Creutzfeldt-Jakob disease (sCJD). However, real-time quaking-induced conversion (RT-QuIC), the most sensitive method an early diagnosis of sCJD, was negative. She developed sCJD six months later, at which time RT-QuIC became positive. The cerebral blood flow decrease cortex (especially supramarginal gyrus) consistent with but increase basal ganglia, probably involved...
Neuroprotective therapeutic potential for restoring dysregulated microRNA (miRNA) expression has previously been demonstrated in a gerbil cerebral infarction model. However, since temporal changes miRNA profiles following stroke onset are unknown, miRNAs proving to be useful targets have yet identified. We evaluated cognitive function, hippocampal neuronal cell death, and microarray-based at 5, 9, 18, 36, 72 h after 5-min whole brain ischemia gerbils. A decline function occurred parallel...
Histopathological changes occur in the brainstem during early stages of Alzheimer's disease (AD), with pathological brain lesions ascending progressively accordance Braak staging system. The senescence‑accelerated mouse prone 8 (SAMP8) model has been previously used as a age‑dependent neurodegenerative diseases, including AD. In present study, microRNAs (miRNAs) that were upregulated or downregulated SAMP8 brainstems identified using miRNA profiling samples obtained from arrays. preliminary...