A5102816338- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Gastrointestinal Tumor Research and Treatment
- Gastric Cancer Management and Outcomes
- Gallbladder and Bile Duct Disorders
- Cancer, Hypoxia, and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Renal cell carcinoma treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Congenital Diaphragmatic Hernia Studies
- Colorectal Cancer Surgical Treatments
- Esophageal and GI Pathology
- Abdominal Trauma and Injuries
- Colorectal and Anal Carcinomas
- Antiplatelet Therapy and Cardiovascular Diseases
- Antibiotic Resistance in Bacteria
- Esophageal Cancer Research and Treatment
- Biliary and Gastrointestinal Fistulas
- Enhanced Recovery After Surgery
- Cardiac Structural Anomalies and Repair
- Amoebic Infections and Treatments
- Metastasis and carcinoma case studies
- Pericarditis and Cardiac Tamponade
Kagawa University
2018-2024
American Gastroenterological Association
2022
Abstract Background The perioperative factors predicting or influencing early pancreatic ductal adenocarcinoma recurrence are unclear. This study attempted to identify the predictive for post-pancreatectomy and influence of pre- post- operative adjuvant therapy. Methods One hundred fifteen patients undergoing curative resection between 2000 2016 at our institution were retrospectively analyzed. Patients divided into two groups: those who did ( n = 34) not 81) experience a within 6 months...
Abstract Background Pancreatic trauma is reportedly associated with high morbidity and mortality. Main pancreatic duct (MPD) injury critical for treatment. Methods As a study project of the Japanese Society Abdominal Emergency Medicine (JSAEM), we collected data 163 patients who were diagnosed treated at JSAEM board‐certified hospitals from 2006 to 2016. Clinical backgrounds, diagnostic approaches, management strategies, outcomes evaluated. Results Sixty‐four (39%) as having MPD that...
: The efficacy of neoadjuvant chemoradiotherapy (NACRT) followed by pancreatoduodenectomy (PD) in elderly patients with pancreatic ductal adenocarcinoma (PDAC) remains unclear.
There is little data on the correlation between reduction in fluorodeoxyglucose positron emission tomography (FDG-PET) radioactive accumulation and carbohydrate antigen 19-9 (CA19-9) levels with pathological tumor responses (PTRs) prognosis after neoadjuvant chemoradiotherapy (NACRT) for patients pancreatic ductal adenocarcinoma (PDAC).This study was a retrospective analysis of prospectively collected from 102 resectable (R-) borderline (BR-) PDAC who received NACRT, followed by curative...
To evaluate the efficacy and safety of a grasping-type knife, called Clutch Cutter (CC), for colorectal endoscopic submucosal dissection (C-ESD). This was randomized prospective study. Patients who underwent C-ESD neoplasms >20 mm <50 in size were enrolled, dividing into two groups: ESD using needle type dual knife alone (D-group) circumferential incision followed by CC (CC-group). The primary outcome self-completion rate. secondary outcomes intraoperative complication rate, procedure time,...
Recent studies have reported that immune checkpoint inhibitors are effective against various defective mismatch repair (dMMR)/microsatellite instability‑high (MSI‑H) cancers. A limited number of reports available on the frequency dMMR/MSI‑H carcinoma in biliary tract cancer (BTC), describing its clinicopathological characteristics and prognosis. The latter is also associated with Lynch syndrome (LS). present study was performed to investigate patients BTC clinical a single institution Japan....
Abstract Background Inflammatory nutritional factors, such as the neutrophil/lymphocyte ratio (NLR), Glasgow Prognostic Score (GPS), modified GPS (mGPS), and C-reactive protein/albumin (CRP/Alb) ratio, have prognostic values in many types of cancer. In this study, inflammatory scores were evaluated patients with resectable or borderline pancreatic ductal adenocarcinoma (PDAC) after neoadjuvant chemoradiotherapy (NACRT). Methods A total 49 who underwent pancreatectomy NACRT from September...
Objective A significant number of patients experience early recurrence after surgical resection for pancreatic ductal adenocarcinoma (PDAC), negating the benefit surgery. The present study conducted clinicopathologic and metabolomic analyses to explore factors associated with PDAC. Materials Methods Patients who underwent pancreatectomy PDAC at Kagawa University Hospital between 2011 2020 were enrolled. Tissue samples nonneoplastic pancreas collected frozen immediately resection. Charged...
Abstract Background Despite a strong association between nutritional indices and disease prognosis, evidence regarding the evaluation of after preoperative treatment for pancreatic ductal adenocarcinoma (PDAC) is insufficient. We evaluated clinical significance prognostic index (PNI) in patients with resectable (R‐) borderline (BR‐) PDAC who received neoadjuvant chemoradiotherapy (NACRT) followed by resection. Methods assessed 153 R‐ BR‐PDAC underwent NACRT curative resection 2009 2022. PNI...
Objectives Indications of preoperative treatment for resectable (R-) or borderline (BR-) pancreatic ductal adenocarcinoma (PDAC) are unclear, and the protocol remains to be standardized. Methods Included 65 patients with R- BR-PDAC venous involvement (V-) received neoadjuvant chemoradiotherapy S-1 50 Gy radiation as 5-week regimen. The outcomes this group were compared those 52 who underwent 30 2-week regimen, previously collected our prospective phase II study. Results Compared there no...
We investigated the metabolic changes in pancreatic ductal adenocarcinoma to identify mechanisms of treatment response neoadjuvant chemoradiation therapy.Frozen tumor and non-neoplastic pancreas tissues were prospectively obtained from 88 patients with who underwent curative-intent surgery. Sixty-two received therapy 26 did not receive (control group). Comprehensive analysis metabolites tissue was performed by capillary electrophoresis-mass spectrometry.Capillary spectrometry detected 90 for...
A solitary fibrous tumor (SFT) is a mesenchymal lesion, which commonly develops in the thorax. Non-islet cell hypoglycemia rare paraneoplastic phenomenon caused by an extra-pancreatic tumor. We report case of pelvic SFT with severe hypoglycemia, was considered to be Doege-Potter syndrome. 72-year-old man referred our hospital for treatment and large His blood glucose level 52 mg/dl; serum insulin level, 1.0 μIU/ml; C-peptide 0.2 ng/ml; insulin-like growth factor-I (IGF-I) 31 ng/ml....
Abstract Background It is important to understand the branching pattern of celiac artery for a safe surgery. Various anomalies were classified by Adachi in 1928. In Adachi’s classification, type VI (group 26) rare anatomical anomaly (0.4%) that requires care when carrying out surgery gastric cancer patients with this anomaly. Herein, we reported case treated successfully laparoscopic distal gastrectomy D1+ lymph node dissection early cancer. Case presentation An 84-year-old female was...
The goal of this retrospective study was to clarify the clinical implications immunohistochemically detected protein expression for genes that are frequently mutated in pancreatic neuroendocrine tumors (PNETs).The management PNETs is hindered by their heterogenous biological behavior. Whole-exome sequencing recently showed 5 (DAXX/ATRX, MEN1, TSC2, and PTEN) PNETs. However, associated alterations remain unclear.We collected Grade 1 2 (World Health Organization 2017 Classification) primary...
KRAS, P16, TP53, and SMAD4/DPC4 mutations are common in pancreatic ductal adenocarcinoma (PDAC). The study aimed to evaluate the association between gene pre-treatment endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) samples clinical outcomes of patients with PDAC.There were 43 resectable (R) PDAC 41 borderline (BR) PDAC. CDKN2A/p16, evaluated through immunohistochemistry (IHC) pretreatment EUS-FNA (n = 84) resected specimens 71). All received neoadjuvant therapy.IHC revealed...
The observation of spontaneous regression (SR) has been well documented for many cancer types, including renal cell carcinoma, non-Hodgkin's lymphoma, leukemia, neuroblastoma, and malignant melanoma. However, the SR frequency in colorectal is very rare. Therefore, accumulation cases might contribute to find mechanism.A 67-year-old woman received colonoscopy due being positive fecal occult blood testing was diagnosed as having a transverse colon at local hospital. She admitted our institution...
Although the efficacy of neoadjuvant therapies for pancreatic cancer (PDAC) is reported in recent years, ideal treatment patients with potentially resectable (R) PDAC remains uncertain. We conducted retrospective study about effect short-term chemoradiotherapy (sNACRT) on R PDAC. The 94 received curative intent pancreatectomy between 2000 and 2016. Among them, 31 sNACRT (S1 60 mg/m2/day 2w RTx 30 Gy/2w). Clinical outcomes were analyzed comparison 63 without sNACRT. 1-, 3-, 5-year overall...
Abstract Objective Limitations are sometimes encountered in the application of laparoscopic cholecystectomy to treatment acute cholecystitis. Endoscopic gallbladder stenting (EGBS) has emerged as an additional option. However, long‐term stent patency remains issue. This study was performed compare efficacy primary and secondary EGBS. Methods Sixty‐one patients who underwent preplanned EGBS because poor surgical tolerance from January 2006 July 2023 were retrospectively analyzed. The divided...