A5102954812- Semiconductor Quantum Structures and Devices
- Pancreatic and Hepatic Oncology Research
- Chalcogenide Semiconductor Thin Films
- Colorectal Cancer Treatments and Studies
- Quantum Dots Synthesis And Properties
- Solid State Laser Technologies
- Cardiovascular Function and Risk Factors
- Neuroendocrine Tumor Research Advances
- Semiconductor Lasers and Optical Devices
- Cardiovascular Health and Disease Prevention
- Cancer Genomics and Diagnostics
- Advanced Semiconductor Detectors and Materials
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Treatment and Pharmacology
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Pancreatitis Pathology and Treatment
- Semiconductor materials and devices
- Blood Pressure and Hypertension Studies
- Genetic factors in colorectal cancer
- Cancer Diagnosis and Treatment
- Semiconductor materials and interfaces
- Renal cell carcinoma treatment
Kagawa University Hospital
2010-2025
Kagawa University
2011-2024
National Cancer Center Hospital East
2011-2020
National Institutes of Health
2020
Yale University
2020
Harvard University
2020
Rockefeller University
2020
National Cancer Center
2013
Meiji Pharmaceutical University
2013
National Center for Global Health and Medicine
2011
We propose a new material, ZnMgSSe, as the cladding layer of blue-light laser diode. Band-gap energy can be varied from 2.8 to near 4 eV, maintaining lattice-matching (100)GaAs substrate. The band-gap energies MgS and MgSe (zincblende structure) are estimated about 4.5 eV 3.6 lattice constants 5.62 Å 5.89 Å, respectively. refractive index ZnMgSSe lattice-matched GaAs is smaller than that ZnSSe GaAs. meets requirements for fabricating
Continuous-wave operation in wide-gap II-VI semiconductor current injection laser diodes at room temperature has been demonstrated for the first time. Stimulated emission was observed a wavelength of 523.5 nm with threshold 45 mA (1.4 kA/cm2) from ZnCdSe/ZnSe/ZnMgSSe single-quantum-well (SQW) separate-confinement heterostructure (SCH) diodes.
This study compared the efficacy of regorafenib and trifluridine/tipiracil (TFTD) in patients with metastatic colorectal cancer (mCRC) who are refractory to standard chemotherapy, because despite their clinical approval, it still remains unclear which these two drugs should be used as initial treatment.The data mCRC were treated or TFTD those drug-naive patients, between June 2014 September 2015, retrospectively collected from 24 institutions Japan. Overall survival (OS) was evaluated using...
A II-VI laser diode lifetime of > 140 h at 40°C, as well ~400 20°C, has been achieved for a ZnCdSe/ZnSSe/ZnMgSSe separate-confinement heterostructure under continuous-wave operation with constant output power 1 mW. Progress made towards increasing the basic reliability ZnMgSSe-based wide bandgap diodes by reducing point defects.
The continuous wave operation of an ZnSe/ZnMgSSe laser diode was achieved for the first time at 77K. Blue stimulated emission observed a wavelength 447nm and threshold current density 225A/cm2.
The band-gap energy of II-VI compound semiconductors was simply calculated using a modified dielectric theory. energies MgS and MgSe were 4.62 3.67 eV. From the extrapolation ${\mathrm{Zn}}_{1\ensuremath{-}x}{\mathrm{Mg}}_{x}\mathrm{Se}$ ${\mathrm{Zn}}_{1\ensuremath{-}x}{\mathrm{Mg}}_{x}\mathrm{S},$ zinc blende at room temperature determined to be 3.59 $4.45\ifmmode\pm\else\textpm\fi{}0.2\mathrm{eV},$ almost same as value bowing parameter ternary alloy experimentally obtained 0 eV, which can...
At room temperature (296 K), continuous-wave (CW) operation of a blue laser diode has been achieved. The emission wavelength is 489.9 nm, and the threshold current voltage 93 mA (1.5 kA/cm2) 6.3 V, respectively. consists ZnCdSe/ZnSSe/ZnMgSSe single-quantum-well (SQW) separate-confinement heterostructure (SCH).
Most advanced elderly cancer patients experience fatigue, anorexia, and declining physical function due to cachexia, for which effective interventions have not been established. We performed a phase I study of new nonpharmacological multimodal intervention called the nutritional exercise treatment (NEXTAC) program reported excellent feasibility compliance with this in who were at risk cachexia. report here background, hypothesis, design next-step multicenter, randomized II evaluate efficacy...
The purpose of the present study was to examine seasonal blood pressure variation and its relationship environmental temperature in healthy elderly Japanese, as studied by home measurements. Fifteen Japanese (79.3 +/- 5.9 yrs) measured their at each morning for more than 25 times per month 3 years. Monthly mean outdoor temperatures were obtained from Takamatsu meteorological Observatory. highest levels systolic diastolic observed February (129 14 81 13 mmHg). lowest August (117 11 73 10...
This study investigated the ability of serum levels C-reactive protein (CRP) to stratify aggressiveness advanced pancreatic cancer (PCa), including poor outcomes, systemic weakness, and extent disease in patients receiving first-line chemotherapy.The prognostic CRP classification was constructed retrospective cohort, consisting PCa with gemcitabine monotherapy (GEM). Stratification using validated for relationships prospective treatment-naive without obvious infections who received GEM or...
660 Background: The 2017 edition of the WHO classification categorized neuroendocrine neoplasms (NEN) as tumors (NET) G1, G2, G3, and carcinoma (NEC). Prior to 2017, NET G3 was NEC in 2010 classification. Platinum-based chemotherapy, commonly used first-line treatment for these tumors, shows suboptimal efficacy G3. Additionally, large-scale studies robust evidence on chemotherapy outcomes are lacking. We investigated regimens evaluated their outcomes. Methods: included 73 patients (pts) who...
Background Stair ascent/descent pose significant challenges after total knee arthroplasty (TKA); however, the exact flexion range of motion (ROM) and quadriceps strength requirements remain unclear. Objective To establish criteria for ROM to determine independence in stair evaluate accuracy combination these factors patients with bilateral TKA. Methods Patients TKA were cross-sectionally assessed at 1 year postoperatively ascent/descent. Receiver operating characteristic curves provided...
We have carried out structural studies of nonluminescent areas developed by current injection in ZnMgSSe alloy-based II–VI blue light emitting diodes electroluminescence topography and transmission electron microscopy. The nonradiative regions, which spread the 〈100〉 direction during injection, consist a high density dislocation dipoles loops. source these defects is preexisting stacking faults originating at substrate/epilayer interface. themselves are aligned along both 〈110〉 directions...
N-doped p-type ZnMgSSe was grown by molecular beam epitaxy. Nitrogen induced electron cyclotron resonance plasma. The maximum net acceptor concentration (NA−ND) and the activation energy of nitrogen (EN) depend on band-gap ZnMgSSe. With increasing energy, NA-ND is decreased EN increased. with a 3.05 eV at 77 K are 2.5×1016 cm−3 140 meV, respectively.
The properties of isoelectronic oxygen in II-VI semiconductors were studied by photoluminescence measurements. It was found that CdTe, CdS, and ZnS can act as an acceptor well ZnSe, the levels CdSe, are shallower than those typical acceptors such Na. Charge transfer from host lattice to atom may play important role acting acceptor. Based on charge-transfer model, it be qualitatively interpreted there two roles compounds: or a trap, they classified ionicity compound. We also now understand...
Blue-green laser diodes exhibiting continuous-wave operation during hundreds-of-seconds have been fabricated. This structure is a ZnCdSe/ZnSSe/ZnMgSSe separate-confinement heterostructure with low dislocation density of ∼10 5 cm -2 in the n-ZnMgSSe cladding layer. The use GaAs buffer layer has lead to decrease for laser-diodes, which we observed CW up 80° C, that showed feasibility SCH laser-diodes.
The diameter of the inferior vena cava (IVC) measured with echocardiography is clinically used as a parameter to estimate right atrial pressure, which reflects dehydration or overhydration. Because elderly patients fall easily into dehydration, normal values for IVC diameters in may be helpful geriatric medicine. However, relation age have not been investigated. purpose this study was elucidate age-related changes using echocardiography. Enrolled were 200 (67 ± 15 yrs: range 17-94 yrs)...
Room temperature pulsed operation of ZnCdSe/ZnSe/ZnMgSSe SCH lasers has been achieved. Blue-green stimulated emission is observed at a wavelength 498.5 nm. The threshold current density 2.8 kA/cm2 for the diode made by molecular beam epitaxy.
<b><i>Background:</i></b> Platinum-containing regimens are widely used as first-line chemotherapy for unresectable pancreatic neuroendocrine carcinoma (NEC), but second-line chemotherapies have yet to be established. <b><i>Objectives:</i></b> We evaluated the safety and efficacy of everolimus in patients with NEC refractory or intolerant platinum-containing chemotherapy. <b><i>Methods:</i></b> This study was a...