A5061777118- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Liver Disease Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Pancreatitis Pathology and Treatment
- Gallbladder and Bile Duct Disorders
- Gastrointestinal disorders and treatments
- Gastroesophageal reflux and treatments
- IgG4-Related and Inflammatory Diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Gastrointestinal motility and disorders
- Helicobacter pylori-related gastroenterology studies
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Gastrointestinal Tumor Research and Treatment
- Cancer Research and Treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease and Transplantation
- Diet, Metabolism, and Disease
- Lipid metabolism and disorders
- Genetic factors in colorectal cancer
Yokohama City University
2016-2025
Yokohama City University Hospital
2014-2025
Yokohama City University Medical Center
2024-2025
Osaka National Hospital
2018
University Gastroenterology
2007-2009
National Cancer Research Institute
2007
Fujisawa City Hospital
1998
Abstract Purpose: Tumor-infiltrating lymphocytes represent the host immune response to cancer. CD4+CD25+FOXP3+ regulatory T cells (Tregs) suppress reaction. The aim of present study was investigate clinicopathologic significance and roles Tregs CD8+ during hepatocarcinogenesis. Experimental Design: We examined infiltration FOXP3+ in tumor stroma nontumorous liver parenchyma using 323 hepatic nodules including precursor lesions, early hepatocellular carcinoma (HCC), advanced HCC, along with...
Purpose: Patients with pancreatic neuroendocrine neoplasm grade-3 (PanNEN-G3) show variable responses to platinum-based chemotherapy. Recent studies indicated that PanNEN-G3 includes well-differentiated tumor G3 (NET-G3). Here, we examined the clinicopathologic and molecular features of assessed responsiveness chemotherapy survival.Experimental Design: A total 100 patients were collected from 31 institutions, after central review characteristics each histologic subtype [NET-G3 vs. carcinoma...
Breast cancer is the most common and deadliest among women in world. Treatment options for HER2-positive metastatic breast patients are limited. Trastuzumab deruxtecan (T-DXd), an antibody-drug conjugate (ADC), has recently been introduced as second-line chemotherapy cancer. The aim of present study was to evaluate efficacy methionine restriction with oral recombinant methioninase (o-rMETase) a low-methionine diet combined T-DXd, on patient recurrent stage IV
The specific mechanisms of nonalcoholic fatty liver (NAFL) and steatohepatitis (NASH) pathogenesis remain unknown. In the present study we investigated differences between NAFL NASH in terms lipid metabolites serum lipoprotein. all, 104 Japanese subjects (50 men 54 postmenopausal women) with histologically verified disease (NAFLD) (51 NAFL, 53 NASH) were evaluated; all diagnoses based on biopsy findings proposed diagnostic criteria. To investigate humans, carefully examined (1) inflow liver,...
Abstract Neuroendocrine neoplasms (NENs) are rare that occur in various organs and present with diverse clinical manifestations. Pathological classification is important the diagnosis of NENs. Treatment strategies must be selected according to status differentiation malignancy by accurately determining whether neoplasm functioning or nonfunctioning, degree disease progression, presence metastasis. The newly revised Clinical Practice Guidelines for Gastroenteropancreatic Neoplasms (GEP-NENs)...
Background/Aim: Gliomas are the most common and recalcitrant malignant primary brain tumors. All cancer types addicted to methionine, which is a fundamental general hallmark of known as Hoffman effect. Particularly glioma cells exhibit methionine addiction. Because addiction, [<sup>11</sup>C]-methionine positron emission tomography (MET-PET) widely used for imaging in clinical practice, can monitor extent Methionine restriction including recombinant methioninase (rMETase) low-methionine...
<h3>Objective:</h3> No effective drugs have been developed to date prevent or treat non-alcoholic fatty liver disease (NAFLD), although diet modification and exercise improve obesity attempted. Therefore, development of a novel drug/strategy NAFLD is urgently needed. In the present study, concept proposed for treatment NAFLD. <h3>Methods:</h3> Fisher 344 male rats were given choline-deficient, l-amino acid-defined (CDAA) high-fat high-calorie (HF/HC) with without antiplatelet agents,...
Colorectal cancer (CRC) is the third-leading cause of death in world. Although prognosis has improved due to improvement chemotherapy, metastatic CRC still a recalcitrant disease, with 5-year survival only 13%. Irinotecan (IRN) used as first-line chemotherapy for patients unresectable CRC. However, there are severe side effects, such neutropenia and diarrhea, which dose-limiting. We have previously shown that methionine restriction (MR), effected by recombinant methioninase (rMETase),...
Pancreatic cancer has a very poor prognosis with 5-year survival rate of less than 5% among patients distant metastasis, figure that not improved over many decades. Only 10 to 20% are candidates for curative surgery at presentation due the aggressive nature and asymptomatic progression pancreatic cancer. Although first-line chemotherapy, such as FOLFIRINOX gemcitabine + nab paclitaxel, median from 8.5 11.1 months, more effective treatments immediately needed. The aim present study was...
The changes in the liver nonalcoholic fatty disease (NAFLD) range over a wide spectrum, extending from steatosis to steatohepatitis (NASH). However it has remained difficult differentiate between NASH and non-progressive NAFLD on basis of clinical findings alone.In this study we investigated usefulness plasma Pentraxin3 (PTX3) levels predict NASH. Plasma PTX3 was measured 70 patients with histologically verified (28 non-NASH 42 NASH) 10 healthy control subjects.The level significantly higher...
It is difficult to predict the biological behavior of pancreatic endocrine tumors (PETs). Our aim was evaluate prognostic significance certain variables in PETs.The following were examined 37 patients with PETs and then compared other clinicopathologic characteristics: histologic tumor structure; microvessel density (MVD) measured by three different methods, including a unique method involving calculation solid area MVD; endothelial proliferation; immunohistochemical expression vascular...
Abstract Background Spontaneous rupture is rare complication of hepatocellular carcinoma (HCC) with high mortality rate in cirrhotic cases. The aim this study was to determine the factors influencing prognosis cases spontaneously ruptured HCC and investigate outcomes treatments employed, especially transcatheter arterial embolization (TAE). Methods A retrospective multicenter conducted 48 patients spontaneous HCC. Conservative treatment employed 32 (ConT group) TAE performed 16 (TAE group)....
Abstract Background: Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes chronic injury in many countries. Genetic factors are important for development NAFLD, as well environmental factors. Recently an angiotensin II type 1 receptor (AGTR1) has been recognized aetiology fibrosis liver. Objective: In this study we investigated association between gene polymorphism ( ATGR1 ) and NAFLD. Methods: One hundred sixty‐seven NAFLD patients [106 with nonalcoholic steatohepatitis...
Background and Aims: Small intestinal toxicity of low-dose aspirin remains unclear. The purpose this capsule endoscopy study was to assess the incidence small bowel injury in healthy volunteers treated with short-term aspirin. Methods: Healthy subjects were randomly assigned receive for 14 days (Aspirin group) or no drugs (Control group). two treatment occasions separated by a washout period at least 4 weeks. All underwent end each period. Results: After 2 weeks treatment, percentages...
Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor, for which the development of new biomarkers and therapeutic targets has become critical. The main cause poor prognosis in PDAC patients high invasive metastatic potential cancer. In present study, we report signaling pathway that was found to mediate enhanced tumor cell motility pancreatic Semaphorin 4D (Sema4D) ligand known be expressed on different types, been reported involved regulation immune functions, epithelial...
Abstract Background Fibroblast growth factor receptor 2 ( FGFR2 ) rearrangement is expected to be a novel therapeutic target in advanced/recurrent biliary tract cancer (BTC). However, efficient detection and the exact frequency of rearrangements among patients with BTC have not been determined, clinical characteristics rearrangement-positive fully elucidated. We aimed determine those elucidate their clinicopathological characteristics. Methods Paraffin-embedded tumor samples from...
Gut microbiota composition is associated with the pathogenesis of non-alcoholic fatty liver disease. However, association between gut and disease in non-obese patients remains unclear. We compared clinical parameters profiles healthy controls obese disease.We examined by 16S rRNA sequences short-chain acid levels fecal samples from 51 (body mass index <25 kg/m2 ) ≥30 who underwent pathological examination 87 at five hospitals Japan.Although no significant differences other groups were...