A5074810793- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Diet, Metabolism, and Disease
- Liver Diseases and Immunity
- Gastrointestinal motility and disorders
- Prostate Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Treatment and Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Gut microbiota and health
- Pancreatitis Pathology and Treatment
- Diet and metabolism studies
- Cancer, Lipids, and Metabolism
- Alcohol Consumption and Health Effects
- Gastroesophageal reflux and treatments
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Helicobacter pylori-related gastroenterology studies
- Hepatitis B Virus Studies
- Multiple and Secondary Primary Cancers
- Cancer, Hypoxia, and Metabolism
- Drug Transport and Resistance Mechanisms
Yokohama City University
2017-2025
Kyoto University
2013-2025
Juntendo University
2010-2024
Tokyo Metropolitan Institute of Gerontology
2024
Jikei University School of Medicine
2024
Toho University
2024
Yokohama City University Hospital
2019-2023
Osaka University
1960-2022
Fujita Health University Hospital
2019-2021
Fujita Health University Bantane Hospital
2021
Background & AimsAs alternatives to the expensive liver biopsy for assessing fibrosis stage in patients with nonalcoholic fatty disease (NAFLD), we directly compared diagnostic abilities of magnetic resonance elastography (MRE), vibration-controlled transient (VCTE), and two-dimensional shear wave (2D-SWE).MethodsOverall, 231 biopsy-proven NAFLD were included. Intra- inter-observer reproducibility was analyzed using intraclass correlation coefficient a sub-group 70 participants, whom...
Glutathione plays crucial roles in the detoxification and antioxidant systems of cells has been used to treat acute poisoning chronic liver diseases by intravenous injection. This is a first study examining therapeutic effects oral administration glutathione patients with nonalcoholic fatty disease (NAFLD). The was an open label, single arm, multicenter, pilot trial. Thirty-four NAFLD diagnosed using ultrasonography were prospectively evaluated. All underwent intervention improve their...
The treatment of diabetes has a significant impact on the pathogenesis non-alcoholic fatty liver disease (NAFLD). We compared effectiveness tofogliflozin, selective sodium-glucose cotransporter 2 inhibitor, and pioglitazone for NAFLD patients with type mellitus.
Nonalcoholic fatty liver disease (NAFLD) and metabolic dysfunction associated (MAFLD) have important associations with cardiovascular (CVD). The main objective of this study was to compare the frequency incidence rate CVD in NAFLD or MAFLD patients utilizing a large claims database.Using JMDC database from April 2013 March 2019, we retrospectively analyzed data for 1,542,688 2,452,949 people estimate relationship between NAFLD, MAFLD, respectively.The rates were 0.97 (95% CI 0.94-1.01) 2.82...
Abstract The incidence of nonalcoholic fatty liver disease (NAFLD) has recently increased and is related to obesity the associated surge in type 2 diabetes mellitus (T2DM) metabolic syndromes. This trial follows up on our previous work forms part ToPiND study. We aimed combine tofogliflozin pioglitazone treatment for hepatic steatosis patients with NAFLD T2DM. In this open‐label, prospective, single‐center, randomized clinical trial, T2DM a fat fraction ≥10% were assessed based magnetic...
Background Proton pump inhibitors (PPIs) can alleviate upper gastrointestinal injury but paradoxically exacerbate aspirin (ASA)-induced small intestine injury. In this study, our goal was to simulate exacerbation by developing an appropriate animal model, which may help in establishing treatments. Methods: Male mice were fed a 60% fructose diet for 9 weeks, then administered 200 mg/kg ASA 3 h before sacrifice. The PPI omeprazole intraperitoneally once daily weeks. Bifidobacterium bifidum...
Recently, FibroScan-AST (FAST) score was reported to be effective for identifying non-alcoholic steatohepatitis (NASH) with significant activity and fibrosis in fatty liver disease (NAFLD). The aim of this study confirm the diagnostic accuracy FAST Japanese patients compare cut-off values between FibroScan M XL probes.Eighty-two 84 were included verification validation sets, respectively. All diagnosed NAFLD by biopsy two central expert pathologists. Liver stiffness measurements controlled...
Gut microbiota composition is associated with the pathogenesis of non-alcoholic fatty liver disease. However, association between gut and disease in non-obese patients remains unclear. We compared clinical parameters profiles healthy controls obese disease.We examined by 16S rRNA sequences short-chain acid levels fecal samples from 51 (body mass index <25 kg/m2 ) ≥30 who underwent pathological examination 87 at five hospitals Japan.Although no significant differences other groups were...
No reports on both blood and fecal bile acids (BAs) in patients with nonalcoholic fatty liver disease (NAFLD) exist. We simultaneously assessed the serum BA patterns healthy participants those NAFLD.We collected stool samples from 287 5 hospitals Japan (healthy control [HC]: n = 88; mild fibrosis: 104; advanced fibrosis group: 95). Blood were analyzed for BAs 7α-hydroxy-4-cholesten-3-one (C4)-a surrogate marker synthesis ability-from 141 patients. Concentrations of BAs, including cholic acid...
Opioid-induced constipation (OIC) may occur in patients receiving opioid treatment, decreasing their quality of life (QOL). We compared the effectiveness magnesium oxide (MgO) with that naldemedine (NAL) preventing OIC. This proof-of-concept, randomized controlled trial (registration number UMIN000031891) involved 120 cancer scheduled to receive therapy. The were randomly assigned and stratified by age sex MgO (500 mg, thrice daily) or NAL (0.2 once for 12 weeks. change average Japanese...
This study evaluated the impact of aspirin on biochemical recurrence (BCR) rate following robot-assisted radical prostatectomy (RARP) in patients. A database search identified patients who underwent RARP for pT2-3N0M0 disease at any 25 centers between 2011 and 2022, categorized into (n = 350) control groups 5857). Adjustment by 1:1 propensity score matching (PSM) Mahalanobis distance (MDM) created 350 matched pairs. The effect BCR was analysis BCR-free survival. After PSM MDM, 3-year...
Abstract There are limited studies on the improvement of leaky gut with minor inflammation associated various diseases. To explore therapeutic potential Lactiplantibacillus plantarum 22 A-3 , a member Lactobacillus species, in addressing gut. was administered to mice model low dextran sulfate sodium concentrations. The -treated group exhibited amelioration increased intestinal permeability, as indicated by lower blood fluorescein isothiocyanate-dextran levels compared that control group....
ABSTRACT Background High‐risk patients with prostate cancer (PC) frequently experience biochemical recurrence (BCR) after surgery. Thus numerous studies have investigated the efficacy of neoadjuvant therapies for high‐risk PC patients; however, no protocol has been established. This study aimed to assess effect androgen deprivation therapy combined low‐dose estramustine phosphate (EMP) on BCR compared (ADT) alone in high‐ and very PC. Methods retrospective targeted meeting National...
ABSTRACT Aims In March 2024, the American Society of Clinical Oncology recommended combination tremelimumab plus durvalumab as a treatment for advanced hepatocellular carcinoma (HCC). Although safety data first‐line treatments are available, information on adverse events related to late‐line is limited. This study aimed identify risk factors in patients who received this combination. Methods and Results We conducted retrospective cohort from 2023 January 2025 at Yokohama City University...
Aim: Vascular calcification, a major complication of chronic kidney disease (CKD), refers to the mineralization vascular smooth muscle cells (VSMCs), resulting from phenotypic change towards osteoblast-like cells. Histone deacetylase inhibitors (HDIs), potential therapeutic agents for CKD, are known promote differentiation and osteoblasts. In this study, we aimed determine effects an HDI on VSMCs development calcification.Methods: The effect trichostatin A (TSA), HDI, human aortic (HASMCs)...