A5068805568- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Liver Disease Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Cardiac Ischemia and Reperfusion
- Liver Disease and Transplantation
- Anesthesia and Sedative Agents
- Cardiac electrophysiology and arrhythmias
- Gastrointestinal motility and disorders
- Nitric Oxide and Endothelin Effects
- Gastroesophageal reflux and treatments
- Cardiac Imaging and Diagnostics
- Physics of Superconductivity and Magnetism
- Force Microscopy Techniques and Applications
- Advanced ceramic materials synthesis
- Magnetic Properties and Applications
- Chaos control and synchronization
- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Antibiotic Resistance in Bacteria
- Inflammatory mediators and NSAID effects
- Metastasis and carcinoma case studies
- Quantum chaos and dynamical systems
- Optical Polarization and Ellipsometry
- Antiplatelet Therapy and Cardiovascular Diseases
Daiyukai General Hospital
2021-2024
International University of Health and Welfare
2018-2023
International University Of Health And Welfare Atami Hospital
2018-2023
Tokyo Metropolitan Institute of Gerontology
2023
Shiga University of Medical Science Hospital
2022
Shinshu University Hospital
2020-2021
Yokohama City University
2014-2020
Wayne State University
2014-2019
University of Tsukuba
2012-2015
University of Electro-Communications
2015
We describe a novel method for the spectroscopic measurement of state polarization (SOP) light. A pair thick birefringent retarders is incorporated into polarimeter, so generated channeled spectrum composed three quasi-cosinusoidal components carrying information about SOP light that being measured. Fourier inversion provides significant parameters determination spectrally resolved Stokes No mechanically movable control or active devices modulation are used, and all can be determined at once...
Optical and electrical properties of sputtered Ge 2 Sb Te 5 films in amorphous crystalline states have been studied. The optical band-gaps amorphous, cubic (NaCl-type), hexagonal are 0.74, 0.5, 0.5 eV, respectively. Electrically, the behave as semiconductors with activation energies 0.45 0.14 while state is metallic. resistivity decreases slightly at melting point ∼600°C. All show p -type thermoelectric power, which 0.3 eV. Carrier parameters electronic densities-of-states estimated considered.
In recent years, nonalcoholic steatohepatitis (NASH) has become a considerable healthcare burden worldwide. Pathogenesis of NASH is associated with type 2 diabetes mellitus (T2DM) and insulin resistance. However, specific drug to treat lacking. We investigated the effect selective sodium glucose cotransporter inhibitor (SGLT2I) ipragliflozin on in mice.We used Amylin liver model (AMLN), which diet-induced that results obesity T2DM. AMLN mice were fed an diet for 20 weeks. SGLT2I 12 weeks 40...
Glutathione plays crucial roles in the detoxification and antioxidant systems of cells has been used to treat acute poisoning chronic liver diseases by intravenous injection. This is a first study examining therapeutic effects oral administration glutathione patients with nonalcoholic fatty disease (NAFLD). The was an open label, single arm, multicenter, pilot trial. Thirty-four NAFLD diagnosed using ultrasonography were prospectively evaluated. All underwent intervention improve their...
The natural polyphenol compound resveratrol (RSV) is considered to have a broad spectrum of beneficial biological activities upon human health. However, the exact effect RSV on steatosis (a phenotype non-alcoholic fatty liver [NAFL]) or fibrosis and inflammation (major phenotypes steatohepatitis [NASH]) not known. Our data showed that administration (2 20 mg/kg/day) did suppress in high-fat diet-induced model NAFL mice. In contrast, identical concentrations dramatically inhibited low-dose...
T-2 toxin is a trichothecene mycotoxin produced when Fusarium fungi infect grains, especially oats and wheat. Ingestion of contaminated grain can cause diarrhea, hemorrhaging, feed refusal in livestock. Cereal crops infected with mycotoxin-producing form glycosides, sometimes called masked mycotoxins, which are potential food safety concern because they not detectable by standard approaches may be converted back to the parent during digestion or processing. The work reported here addresses...
Background Proton pump inhibitors (PPIs) can alleviate upper gastrointestinal injury but paradoxically exacerbate aspirin (ASA)-induced small intestine injury. In this study, our goal was to simulate exacerbation by developing an appropriate animal model, which may help in establishing treatments. Methods: Male mice were fed a 60% fructose diet for 9 weeks, then administered 200 mg/kg ASA 3 h before sacrifice. The PPI omeprazole intraperitoneally once daily weeks. Bifidobacterium bifidum...
Infectious diseases due to multidrug-resistant pathogens, particularly carbapenem-resistant Enterobacteriaceae (CREs), present a major and growing threat human health society, providing an urgent need for the development of improved potent antibiotics their treatment. We describe design new class aminoglycoside culminating in discovery propylamycin. Propylamycin is 4'-deoxy-4'-alkyl paromomycin whose alkyl substituent conveys excellent activity against broad spectrum ESKAPE pathogens other...
Flavin adenine dinucleotide (FAD) undergoes multisite molecular recognition at the air-water interface with mixed monolayers that are capable of complementary hydrogen bonding. Molecular images were obtained an atomic force microscope (AFM) for guanidinium (G) and orotate (O) amphiphiles transferred from pure water aqueous FAD. The AFM image G/O monolayer on FAD showed a periodic oblique pattern composed two kinds methyl peaks different heights, whereas hexagonal only one kind peak....
Analysis of DNA gyrase supercoiling and norfloxacin uptake in Escherichia coli GN14176, a moderately norfloxacin-resistant clinical isolate, indicated that resistance was associated with both an altered drug target reduction uptake.
Summary. The FIB‐4 index is a simple formula to predict liver fibrosis based on the standard biochemical values (AST, ALT and platelet count) age. We here investigated utility of for noninvasive prediction progression in fibrosis. time‐course alteration stage between paired biopsies was examined 314 patients with chronic hepatitis C. average interval 4.9 years. cases that showed improvement exhibited decrease index, those deterioration an increase significant correlation ( P < 0.001)....
Background and aims The barrier function of the small intestinal mucosa prevents introduction undesired pathogens into body. Breakdown this increases permeability. This has been proposed to induce not only gastrointestinal diseases, including inflammatory bowel disease irritable syndrome, but also various other allergies, diabetes mellitus, liver collagen which are associated with so called "leaky gut syndrome." As such, a method prevent leaky syndrome would have substantial clinical value....
Opioid-induced constipation (OIC) may occur in patients receiving opioid treatment, decreasing their quality of life (QOL). We compared the effectiveness magnesium oxide (MgO) with that naldemedine (NAL) preventing OIC. This proof-of-concept, randomized controlled trial (registration number UMIN000031891) involved 120 cancer scheduled to receive therapy. The were randomly assigned and stratified by age sex MgO (500 mg, thrice daily) or NAL (0.2 once for 12 weeks. change average Japanese...
ABSTRACT The emerging epidemic of drug resistance places the development efficacious and safe antibiotics in spotlight current research. Here, we report design next-generation aminoglycosides. Discovery efforts were driven by rational synthesis focusing on 4′ alkylations aminoglycoside paromomycin, with goal to alleviate most severe disabling side effect aminoglycosides—irreversible hearing loss. Compounds evaluated for target activity vitro ribosomal translation assays, antibacterial...
With the aging of population and rising incidence thromboembolic events, usage antiplatelet agents is also increasing. There are few reports yet on management for patients undergoing colorectal endoscopic submucosal dissection (ESD).The aim this study to evaluate whether continued administration associated with an increased rate delayed bleeding after ESD.A total 1022 neoplasms in 927 were dissected at Yokohama City University Hospital its three affiliate hospitals between July 2012 June...
Atomic force microscopy observations of a (hydrocarbon guanidinium/fluorocarbon carboxylic acid) mixed monolayer revealed that nanoscopic phase-separated structure was formed by combination attractive interaction between the oppositely charged head groups and repulsive phase separation hydrocarbon fluorocarbon chains.
To evaluate the clinical value of capsule endoscopy (CE) in patients with intestinal Behçet's disease (BD).The present study was a case-control pilot conducted BD and healthy volunteers. A total 19 (intestinal group) volunteers (control matched for age sex were enrolled. Frequency, number small bowel lesions per subject, Lewis score comparatively evaluated between two groups.Of BD, 18 (94.7%) had reddened lesions, 15 (78.9%) erosions, nine (47.4%) ulcers. There significant differences...
Hexopyranose side chains populate three staggered conformations, whose proportions can be determined from the sets of ideal limiting