A5070972892- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Renal cell carcinoma treatment
- Testicular diseases and treatments
- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Liver Diseases and Immunity
- Cancer, Lipids, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Microfluidic and Capillary Electrophoresis Applications
- Prostate Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Hypoxia, and Metabolism
- Renal and related cancers
- Urologic and reproductive health conditions
- Innovative Microfluidic and Catalytic Techniques Innovation
- Microfluidic and Bio-sensing Technologies
- RNA Interference and Gene Delivery
- Urinary and Genital Oncology Studies
- Sarcoma Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Photodynamic Therapy Research Studies
Musashino Red Cross Hospital
2015-2024
Tokyo Medical and Dental University
2022-2023
Nantan General Hospital
2018-2020
Kyoto Medical Center
2017-2018
Juntendo University
2012-2017
Kyoto Prefectural University of Medicine
2003-2016
Nakanishi (Japan)
2015
Tokyo National Hospital
2010-2015
Japanese Urological Association
2011-2015
Meteorological Research Institute
2015
Prostate cancer gene 3 (PCA3) has shown promise as a molecular marker in prostate detection. We assessed the association of urinary PCA3 score with prostatectomy tumor volume and other clinical pathological features.Urine specimens were collected after digital rectal examination from 59 men scheduled for biopsy 83 radical prostatectomy. Prostatectomy findings evaluable 96 men. specific antigen mRNAs quantified Gen-Probe DTS 400 System. The was defined ratio mRNA/prostate mRNA x10(3).The...
An increase in the aging population is an impending problem. A large cohort study was carried out to determine influence of and other factors on hepatocarcinogenesis patients treated with interferon. Biopsy-proven 2547 chronic hepatitis C registered at our referral center since 1992 were included. Of these, 2166 interferon-based therapy. Incidences hepatocellular carcinoma (HCC) associated interferon analyzed by Kaplan-Meier person-years methods for average follow-up 7.5 years. Factors HCC...
The effects of interferon (IFN) treatment and the post-IFN α-fetoprotein (AFP) levels on risk hepatocellular carcinoma (HCC) in patients with chronic hepatitis C (CHC) are unknown. To determine relationship between AFP alanine transaminase (ALT) HCC risk, a cohort consisting 1,818 histologically proven to have CHC treated IFN were studied. Cumulative incidence analyzed over mean follow-up period 6.1 years using Kaplan-Meier method Cox proportional hazard analysis. developed 179 study...
A multisociety consensus group proposed a new nomenclature for metabolic dysfunction-associated steatotic liver disease (MASLD). Although patients with nonalcoholic fatty (NAFLD) are expected to be reclassified as MASLD under the nomenclature, concordance between and NAFLD remains unclear. Moreover, waist circumference could adjusted by ethnicity diagnosing MASLD; however, there limited data on optimal in Japanese population.
ABSTRACT Porphyromonas gingivalis is one of the major causative organisms periodontitis and has been shown to be susceptible toluidine blue-mediated photosensitization in vitro. The aims present study were determine whether this technique could used kill organism oral cavities rats would result a reduction alveolar bone loss characteristic periodontitis. maxillary molars inoculated with P. exposed up 48 J 630-nm laser light presence blue. number surviving bacteria was then determined,...
We evaluated the hypothesis that circulating tumor cells as determined using CellSearch System would correlate with volume, pathological stage and Gleason score in men localized prostate cancer.Samples of blood (30 ml) were drawn from 97 cancer before radical prostatectomy, on postoperative days 2 to 3 at 6 weeks. A control group consisted 25 an increased specific antigen no detected extended biopsy. Samples analyzed for System.Circulating 21% patients 20% controls (p = 0.946). At weeks...
X-linked inhibitor of apoptosis protein (XIAP) is the most potent caspase-inhibitory IAP family member and a negative regulator various apoptotic stimuli. Thus, XIAP overexpression in cancer cells may select for tumor cell survival following cytotoxic therapeutic modalities. The anatomical staging system renal carcinoma (RCC) currently provides good prognostic information, albeit insufficient. We hypothesize that RCC serve as molecular marker improve RCC. This study examined level lysates...
<i>Objectives:</i> The aim of this study was to investigate the relationships between early changes in tumor markers α-fetoprotein (AFP) and des-γ-carboxy prothrombin (DCP), antitumor response period following administration sorafenib patients with advanced hepatocellular carcinoma (HCC). <i>Methods:</i> Forty-eight HCC were evaluated. AFP DCP measured at baseline, after 2 4 weeks, responses evaluated according RECIST criteria weeks starting therapy. ratios each...
Aim Intermediate‐stage hepatocellular carcinoma varies widely in tumor burden and liver function. This study aimed to clarify the importance of subclassification by up‐to‐seven criteria both clinical course function deterioration such patients. Methods We retrospectively analyzed 224 patients with Child–Pugh grade A who underwent initial transarterial chemoembolization (TACE) for carcinoma. Tumor downstaging within Milan 1 year worsening as from B were analyzed. Results The median survival...
The present study aimed to investigate the impact of pre-sarcopenia on prognosis patients with advanced hepatocellular carcinoma (HCC) treated sorafenib.We enrolled 214 (71 ± 10 years old; 166 men and 48 women; 90% Child-Pugh grade A 10% B) sorafenib in our hospital from July 2009 August 2016. muscle volume was measured CT images just before administration using software (SliceOmatic). Skeletal mass index calculated, presence judged according standard (42 cm2/m2 for 38 women) proposed by...
Magnetic resonance elastography (MRE) has the highest diagnostic accuracy for liver fibrosis; however, association between MRE-associated stiffness and development of hepatic extrahepatic complications as well mortality remains unclear.In this study, we investigated longitudinal mortality.This retrospective study included 2373 consecutive patients with chronic disease. All received standard care was assessed every 1-6 months.Newly diagnosed hepatocellular carcinoma (HCC), decompensation,...
Lenvatinib is an approved first-line therapy for unresectable hepatocellular carcinoma (HCC), but the effect of dose modification on its efficacy unclear. We analyzed relationship between relative intensity during initial 4 weeks [4W-relative (RDI)] and lenvatinib in real-world setting. A total 48 consecutive patients with HCC who received more than were included. The 4W-RDI was calculated as cumulative divided by weight-based standard dose, we evaluated association overall survival (OS)...
The association between liver fibrosis, fatty liver, and cardiovascular disease (CVD) risk is unknown. Hence, this study aimed to investigate the of fibrosis with CVD independent already known comorbidities.This a prospective registered University Hospital Medical Information Network clinical trial registry (UMIN000036175). Liver was assessed by serum markers including FIB-4, nonalcoholic score (NFS), Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA+ -M2BP), whereas...
Purpose Second mitochondria-derived activator of caspase/direct inhibitor apoptosis-binding protein with low pI (Smac/DIABLO) was recently identified as a that is released from mitochondria in response to apoptotic stimuli and promotes apoptosis by antagonizing proteins. Furthermore, Smac/DIABLO plays an important regulatory role the sensitization cancer cells both immune- drug-induced apoptosis. However, little known about clinical significance various cancers, including renal cell...
<i>Objective:</i> Keratin (K) 19 positivity has been reported to be a useful predictive marker for recurrence in patients with hepatocellular carcinoma (HCC) who have undergone hepatic resection. We investigated the clinical usefulness of K19 had received curative radiofrequency ablation (RFA). <i>Methods:</i> retrospectively evaluated clinicopathological features, including imaging and expression, 246 HCC were within Milan criteria RFA. Using two-step insertion...
Hepatic steatosis is linked to development of hepatocellular carcinoma (HCC) in non-viral liver disease such as non-alcoholic steatohepatitis. The present study aimed assess whether hepatic associated with the HCC chronic hepatitis C. We studied a retrospective cohort 1279 patients C who received interferon (IFN) therapy between 1994 and 2005 at single regional hospital Japan. Of these patients, 393 had sustained virological response (SVR) 886 non-SVR IFN therapy. After therapy, were...
Objectives: In 2001, the Cancer Registration Committee of Japanese Urological Association initiated a data collection prostate cancer patients into computer‐based database. The aim present study is to report clinical and pathological characteristics outcomes diagnosed in 2004 Japan. Methods: Overall, 11 385 from 239 institutions were registered After excluding 1105 because insufficient data, duplication or follow up, 10 280 eligible for analysis. Most them (10 198, 99.2%) 1195 (11.6%) had...
BACKGROUND A new predictive biomarker for determining prognosis in patients with hepatocellular carcinoma (HCC) who receive sorafenib is required, because achieving a reduction tumor size rare, even have favorable prognosis. Vascular endothelial growth factor (VEGF) receptor target. In the current study, authors examined changes plasma VEGF concentrations during treatment and determined clinical significance of as prognostic indicator HCC. METHODS Plasma were serially measured 63 advanced...
Wisteria floribunda agglutinin (WFA)-positive human Mac-2-binding protein (WFA(+) -M2BP) is a new glycol marker related to liver fibrosis. The aim of the present study was evaluate WFA(+) -M2BP as predictor hepatocellular carcinoma (HCC) development in patients with chronic hepatitis C.This case-control included 14 C who developed HCC and 52controls, matched for age, gender, fibrosis stage. measured at biopsy follow-up. Time zero set date biopsy.WFA(+) increased stepwise progression (p <...
We identify clinicopathological variables predicting overall survival in patients with recurrent bladder urothelial carcinoma after radical cystectomy.We retrospectively collected data on 114 treated cystectomy for who subsequently had remote metastasis and/or local recurrence. The Kaplan-Meier method the log rank test and multivariate Cox regression models were used to address recurrence.During followup 99 of died. Median was 11.2 months. One 3-year rates 48.0% 12.1%, respectively. On...
Abstract Background and Aim Tenofovir alafenamide (TAF) is a new prodrug of tenofovir, enabling treatment patients with hepatitis B virus (HBV) infection at lower dose than tenofovir disoproxil fumarate (TDF), via more efficient delivery to the hepatocytes. We compared efficacy safety TDF TAF investigated switching from therapy. Methods Consent for therapy was obtained 117 67 August 2014 January 2018. In total, 45 14 were administered TAF, respectively, as naïve therapy, 36 switched TAF. The...
The aim of this study is to clarify the value serum Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA+ -M2BP) for predicting hepatocellular carcinoma (HCC) in chronic hepatitis C patients who achieved sustained virologic response (SVR) by therapy with interferon-free, direct-acting antivirals (DAAs).This a retrospective cohort that included 567 underwent antiviral an interferon-free DAA regimen and SVR. Serum WFA+ -M2BP was measured after Factors predictive HCC occurrence...