A5005996769- Cancer Cells and Metastasis
- Digestive system and related health
- Gut microbiota and health
- Rheology and Fluid Dynamics Studies
- Probiotics and Fermented Foods
- Trace Elements in Health
- Inflammatory Bowel Disease
- Engineering Applied Research
- Helicobacter pylori-related gastroenterology studies
- Wnt/β-catenin signaling in development and cancer
- Heat Transfer and Optimization
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Water Systems and Optimization
- Liver Diseases and Immunity
- Genetic Associations and Epidemiology
- Genetic factors in colorectal cancer
- Cyclone Separators and Fluid Dynamics
- Fluid Dynamics and Mixing
- Escherichia coli research studies
- Animal Nutrition and Physiology
- Hedgehog Signaling Pathway Studies
- Energy and Environmental Systems
- Microbial Metabolites in Food Biotechnology
- Phytoestrogen effects and research
Harvard University
2020-2024
Massachusetts General Hospital
2018-2024
Broad Institute
2018-2024
University of Hawaiʻi at Mānoa
2024
Massachusetts Institute of Technology
2020
Tokyo Medical and Dental University
2013-2018
Tokyo University of Marine Science and Technology
2015-2017
Musashino Red Cross Hospital
2013
University of Yamanashi
2013
Engineering (Italy)
2005
Overcoming a barrier to IBD Inflammatory bowel disease (IBD) is group of disorders linked inflammation the gastrointestinal tract. Colitis type that affects inner lining colon and has been gene known as C1orf106 . Mohanan et al. found encodes protein stabilizes integrity epithelial junctions enhances defense (see Perspective by Citi). IBD-associated mutations in lead greater cytohesin-1 levels, changes E-cadherin localization, enhanced susceptibility intestinal pathogens. Modulation may thus...
Tissue homeostasis is perturbed in a diversity of inflammatory pathologies. These changes can elicit endoplasmic reticulum (ER) stress, protein misfolding, and cell death. ER stress triggers the unfolded response (UPR), which promote recovery proteostasis survival or trigger programmed Here, we leveraged single-cell RNA sequencing to define dynamic transcriptional states associated with adaptive versus terminal UPR mouse intestinal epithelium. We integrated these programs genome-scale CRISPR...
Intestinal stem cells (ISCs) play indispensable roles in the maintenance of homeostasis, and also regeneration damaged intestinal epithelia. However, whether inflammatory environment Crohn's disease (CD) affects properties resident small remain uncertain.CD patient-derived organoids were established from enteroscopic biopsy specimens taken active lesions (aCD-SIO), or mucosa under remission (rCD-SIO). Expression ISC-marker genes those was examined by immunohistochemistry, microfluid-based...
ATOH1 is a master transcription factor for the secretory lineage differentiation of intestinal epithelial cells (IECs). However, comprehensive contribution ATOH1+ IECs to homeostasis, repair, and tumorigenesis epithelium remains uncertain. Through our cell-lineage tracing, we show here that definite number retain stem cell properties can form ATOH1+IEC-derived clonal ribbons (ATOH1+ICRs) under completely homeostatic conditions. Interestingly, colonic appeared exhibit their function more...
BACKGROUND A new predictive biomarker for determining prognosis in patients with hepatocellular carcinoma (HCC) who receive sorafenib is required, because achieving a reduction tumor size rare, even have favorable prognosis. Vascular endothelial growth factor (VEGF) receptor target. In the current study, authors examined changes plasma VEGF concentrations during treatment and determined clinical significance of as prognostic indicator HCC. METHODS Plasma were serially measured 63 advanced...
Common genetic variants interact with environmental factors to impact risk of heritable diseases. A notable example this is a single-nucleotide variant in the Solute Carrier Family 39 Member 8 (SLC39A8) gene encoding missense A391T, which associated variety traits ranging from Parkinson's disease and neuropsychiatric cardiovascular metabolic diseases Crohn's disease. The remarkable extent pleiotropy exhibited by SLC39A8 A391T raises key questions regarding how single coding can contribute...
Intestinal epithelial cells (IECs) regulate the absorption and secretion of anions, such as HCO3- or Cl-. Bestrophin genes represent a newly identified group calcium-activated Cl- channels (CaCCs). Studies have suggested that, among four human bestrophin-family genes, bestrophin-2 (BEST2) bestrophin-4 (BEST4) might be expressed within intestinal tissue. Consistently, study showed that BEST2 is by colonic goblet cells. However, their precise expression pattern along gastrointestinal tract,...
Intestinal epithelial cells (IECs) play an indispensable role in maintaining body fluid balance partly through their ability to regulate anion/fluid secretion. Yet various inflammatory gastrointestinal diseases, over-secretion of anions results symptoms such as severe diarrhoea. Endogenous mediators, vasoactive intestinal peptide or prostaglandin E2 (PGE2), secretion, but direct effect on purified human IECs has never been described detail. Based a previously organoid swelling model, we...
Reports have suggested that the two Notch ligands, Dll1 and Dll4, are indispensable to maintain homeostasis of intestinal epithelium. However, within epithelium, precise distribution cells express those ligands at protein level remains largely unknown. Here, we show a series immunohistochemical analysis through which successfully identified mice epithelial (IECs) endogenously or Dll4. Results showed Dll1-positive (Dll1+ve) IECs reside exclusively crypt, whereas Dll4-positive (Dll4+ve) can...
Real-time tissue elastography (RTE) is a non-invasive method for the measurement of elasticity using ultrasonography. Liver fibrosis (LF) index quantitative evaluation liver calculated by RTE image features. This study aimed to investigate significance LF predicting in chronic hepatitis C patients.In this prospective study, 115 patients with who underwent biopsy were included, and diagnostic accuracy serum markers was evaluated.RTE imaging successfully performed on all patients. Median F0-1,...
Effective tissue repair requires coordinated intercellular communication to sense damage, remodel the tissue, and restore function. Here, we dissected healing response in intestinal mucosa by mapping at single-cell resolution integrating with spatial transcriptomics. We demonstrated that a risk variant for Crohn’s disease, hepatocyte growth factor activator (HGFAC) Arg 509 His (R509H), disrupted damage-sensing pathway connecting coagulation cascade factors drive differentiation of...
Oxidative stress is considered an etiological factor responsible for several symptoms of inflammatory bowel disease (IBD). In vitro anti-inflammatory activities heat-killed Lactococcus lactis subsp. BF3 have been reported. this study, the effect these cells was examined using a dextran sodium sulphate (DSS)-induced murine IBD model. Administration L. via drinking water suppressed symptoms, such as shortening colon length, damage to mucosa observed under microscope, and spleen enlargement....
The data on the immunohistochemical analysis of conditional Notch ligand knockout mice is presented. Targeted deletion Jag1, Dll1, Dll4, or Dll1 plus Dll4 in Lgr5+ve cells was induced by a Cre-mediated gene recombination, and differentiation proliferation intestinal epithelial examined immunohistochemistry. These are extension presented discussed paper entitled "Indispensable role non-canonical signaling Apc-deficient tumors" (Nakata et al., Submitted for publication) [1].