A5022689957- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Uterine Myomas and Treatments
- Cervical Cancer and HPV Research
- Cancer Genomics and Diagnostics
- Endometriosis Research and Treatment
- Genetic factors in colorectal cancer
- Cancer-related molecular mechanisms research
- Bioinformatics and Genomic Networks
- PARP inhibition in cancer therapy
- BRCA gene mutations in cancer
- Colorectal and Anal Carcinomas
- Estrogen and related hormone effects
- Multiple and Secondary Primary Cancers
- Radiomics and Machine Learning in Medical Imaging
- Intraperitoneal and Appendiceal Malignancies
- Cancer Risks and Factors
- Gynecological conditions and treatments
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Renal cell carcinoma treatment
- Cancer, Hypoxia, and Metabolism
- DNA Repair Mechanisms
- Lung Cancer Research Studies
- Genetics, Bioinformatics, and Biomedical Research
Keio University
2016-2025
Keio University Hospital
2012-2025
Ehime University
2024
Institute for Advanced Medical Research
2024
Okinawa Red Cross Hospital
2024
University of Occupational and Environmental Health Japan
2023
Osaka University
2023
Kyushu University
2023
Nihon University
2023
Tohoku University
2023
Abstract Purpose: Tumor-infiltrating lymphocytes represent the host immune response to cancer. CD4+CD25+FOXP3+ regulatory T cells (Tregs) suppress reaction. The aim of present study was investigate clinicopathologic significance and roles Tregs CD8+ during hepatocarcinogenesis. Experimental Design: We examined infiltration FOXP3+ in tumor stroma nontumorous liver parenchyma using 323 hepatic nodules including precursor lesions, early hepatocellular carcinoma (HCC), advanced HCC, along with...
Abstract The use of primary patient-derived organoids for drug sensitivity and resistance testing could play an important role in precision cancer medicine. We developed expandable ovarian < 3 weeks; these captured the characteristics histological subtypes replicated mutational landscape tumours. Seven pairs (3 high-grade serous, 1 clear cell, endometrioid) original tumours shared 59.5% (36.1–73.1%) variants identified. Copy number variations were also similar among organoid that...
The Fourth Edition of the Guidelines for Treatment Uterine Body Neoplasm was published in 2018. These guidelines include 9 chapters: 1. Overview guidelines, 2. Initial treatment endometrial cancer, 3. Postoperative adjuvant therapy 4. Post-treatment surveillance 5. advanced or recurrent 6. Fertility-sparing therapy, 7. uterine carcinosarcoma and sarcoma, 8. trophoblastic disease, 9. Document collection; nine algorithms: 1-3. carcinosarcoma, choriocarcinoma. Each chapter includes overviews...
To examine the incidence and prognostic effects of intraoperative capsule rupture to assess effectiveness postoperative chemotherapy for tumor in apparent stage I epithelial ovarian cancer.This is a society-based retrospective observational study Japan that examined 15,163 women with IA-IC1 cancer who underwent primary surgical treatment between 2002 2015. Associations cause-specific survival, survival among intraoperatively ruptured cases were by histology type (clear cell n=6,107,...
// Akira Hirasawa 1 , Issei Imoto 2 Takuya Naruto Tomoko Akahane Wataru Yamagami Hiroyuki Nomura Kiyoshi Masuda Nobuyuki Susumu 1, 3 Hitoshi Tsuda 4 and Daisuke Aoki Department of Obstetrics Gynecology, Keio University School Medicine, Tokyo, Japan Human Genetics, Graduate Biomedical Sciences, Tokushima University, Tokushima, International Health Welfare, Chiba, Basic Pathology, National Defense Medical College, Saitama, Correspondence to: Hirasawa, email: hir-aki45@umin.org Imoto,...
Objective: Reports on the repeated administration of medroxyprogesterone acetate (MPA) for intrauterine recurrence after fertility-preserving therapy atypical endometrial hyperplasia (AEH) and early grade 1 endometrioid carcinoma (G1) are lacking.We aimed to clarify outcomes MPA in cases with against AEH/early G1.Methods: Patients AEH or stage IA well-differentiated without myometrial invasion who underwent first-line primary lesions were divided into initial treatment groups (162 82...
Patients hoping to preserve their fertility receive conservative treatment with high-dose medroxyprogesterone acetate (MPA) for well-differentiated endometrioid adenocarcinoma (EC) or atypical endometrial hyperplasia (AEH) . Such generally involves frequent intrauterine operations, including dilation and curettage (D&C) biopsy (EMB), which could result in endometritis, thinning, adhesion. In turn, any of these outcomes adversely affect implantation pregnancy development. The current study...
The present study was performed to clarify the significance of DNA methylation alterations during endometrial carcinogenesis. Genome-wide analysis and targeted sequencing tumor-related genes were using Infinium MethylationEPIC BeadChip Ion AmpliSeq Cancer Hotspot Panel v2, respectively, for 31 samples normal control tissue from patients without cancer 81 tissue. Principal component revealed that tumor had a profile distinct samples. Gene Ontology enrichment significant differences at 1034...
The Japan Society of Gynecologic Oncology (JSGO) Guidelines 2022 for the Treatment Uterine Cervical Cancer are revised from 2017 guideline. This guideline aimed to provide standard care cervical cancer, indicate appropriate current treatment methods minimize variances in among institutions, improve disease prognosis and safety, reduce economic psychosomatic burden patients by promoting performance treatment, enhance mutual understanding between healthcare professionals. guidelines were...
Uterine serous cancer (USC) comprises around 10% of all uterine cancers. However, USC accounts for approximately 40% deaths, which is attributed to tumor aggressiveness and limited effective treatment. Galectin 3 (Gal3) has been implicated in promoting aggressive features some malignancies. Gal3's role pathology lacking.
The preferential response to PARP inhibitors (PARPis) in BRCA-deficient and Schlafen 11 (SLFN11)-expressing ovarian cancers has been documented, yet the underlying molecular mechanisms remain unclear. As accumulation of single-strand DNA (ssDNA) gaps behind replication forks is key for lethality effect PARPis, we investigated combined effects SLFN11 expression BRCA deficiency on PARPi sensitivity ssDNA gap formation human cancer cells. PARPis increased chromatin-bound RPA2 SLFN11-expressing...
ABSTRACT Background Borderline ovarian tumors (BOTs) differ from carcinomas in their clinical presentation and behavior, yet molecular characteristics remain poorly understood. This study aims to address this gap by integrating whole‐exome sequencing (WES) RNA (RNA‐seq) compare BOTs with high‐grade serous carcinoma (HGSC), endometrioid (EC), clear‐cell (CCC). Objective To elucidate the features of evaluate similarities differences comparison HGSC, EC, CCC. Methods The analyzed 44 tumor...
This study aimed to assess the prognostic significance of para-aortic lymphadenectomy (PALX) and lymph node metastasis in endometrial cancer (EC) patients at risk post-operative recurrence. Japanese Gynecologic Oncology Group (JGOG) 2043 was a randomized controlled trial assessing efficacy adjuvant chemotherapy EC for A retrospective analysis included who underwent pelvic (PLX) alone or both PLX PALX JGOG2043. Data on positive nodes other clinicopathological factors were collected. performed...
Hereditary breast and ovarian cancer syndrome (HBOC) is traditionally associated with mutations in the BRCA1 BRCA2 genes, predominantly impacting breast, ovarian, pancreatic, prostate cancers. However, recent research suggests that these may also predispose carriers to a broader spectrum of malignancies, including biliary tract, cervical, colorectal, endometrial, esophageal, gastric This review presents findings from extensive datasets, significant study nationwide Japanese biobank examined...
Cervical cancer rates in Japan (16.0/100,000) exceed the global average rate (11.3/100,000, according to High/Very-High Human Development Index 2020). This necessitates evaluation of care quality and indicators (QIs) for cervical that were developed 2013 serve this purpose. study updated these using current evidence consensus while longitudinally examining trends practice patterns. The revision involved reviewing existing QIs patterns incorporating new modified Delphi method. Adherence was...
High-grade serous carcinoma (HGSC), the most aggressive subtype of epithelial ovarian cancer, is strongly associated with hereditary breast and cancer (HBOC) syndrome primarily linked to germline BRCA1/2 pathogenic variants (PVs). The cumulative risks by age 70 years are 40% 18% for carriers BRCA1 BRCA2 PVs, respectively. Risk-reducing salpingo-oophorectomy (RRSO) a recommended preventive strategy that reduces risk more than 80% may improve overall survival. However, surgical menopause after...
Abstract The Japan Society of Obstetrics and Gynecology collects analyzes annual data on gynecologic cancers from member institutions. Here we present the Treatment Annual Report for 2007. Data prognosis 3381 patients with cervical cancer, 3681 endometrial 2367 ovarian cancer whom treatment was initiated in 2007 were analyzed Report. In Report, stage I accounted 53.1%, II 24.4%, III 14.2%, IV 8.3% all cancer. Stage 64.8%, 8.2%, 20.2%, 6.9% 41.4%, 9.9%, 30.6%, 8.6% 5‐year overall survival...