A5067125521- Genetic factors in colorectal cancer
- Ovarian cancer diagnosis and treatment
- Cancer Genomics and Diagnostics
- Endometrial and Cervical Cancer Treatments
- BRCA gene mutations in cancer
- DNA Repair Mechanisms
- Microtubule and mitosis dynamics
- Bacteriophages and microbial interactions
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Bacterial Genetics and Biotechnology
- Cancer, Hypoxia, and Metabolism
- Multiple and Secondary Primary Cancers
- Genomics and Chromatin Dynamics
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Screening and Detection
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- PARP inhibition in cancer therapy
- PI3K/AKT/mTOR signaling in cancer
- Metabolism, Diabetes, and Cancer
- Cancer Mechanisms and Therapy
- Cancer-related Molecular Pathways
- Circular RNAs in diseases
- Cervical Cancer and HPV Research
Keio University
2015-2025
Keio University Hospital
2011-2025
Hiroshima University
2014-2023
Yonsei University
2023
University of Ulsan
2023
Asan Medical Center
2023
Ulsan College
2023
Qilu Hospital of Shandong University
2023
Jichi Medical University
2023
University College London
2023
Lynch syndrome is a hereditary ovarian cancer with prevalence of 0.9-2.7%. accounts for 10-15% cancers, while breast and 65-75% these cancers. The lifetime risk in families ~8%, which lower than colorectal endometrial not listed the Amsterdam Criteria II. More half sporadic cancers are diagnosed stage III or IV, but ≥80% I Ovarian mostly have non-serous histology different properties from those A screening method has yet to be established clinical studies prophylactic administration oral...
The number of copies rRNA (rrn) operons in a bacterial genome differs greatly among species. Here we examined the phenotypic effects variations genes Bacillus subtilis by analysis eight mutant strains constructed to carry from two nine rrn operon. We found that decrease ten one increased doubling time, and decreased sporulation frequency motility. maximum levels for transformation activity were similar strains, although competence development was significantly delayed strain with single...
Peutz‑Jeghers syndrome (PJS) is an autosomal dominant disease that characterized by gastrointestinal hamartomatous polyposis and mucocutaneous melanin spots. The tumor suppressor gene, STK11/LKB1, which located on chromosome 19p13.3, has been reported to be responsible for this condition. PJS complicated benign malignant tumors of various organs complications from rare diseases, including sex cord with annular tubules (SCTAT) minimal deviation adenocarcinoma (MDA), have also recently...
Drug repositioning is an alternative strategy redirecting existing drugs for new disease. We have previously reported antitumor effect of statins, antidyslipidemic drugs, on ovarian cancer in vitro and vivo. In this study, we investigated the effects other mevalonate pathway inhibitors mechanism from a metabolic perspective. The tumor cell growth were evaluated vitro. Bisphosphonates that inhibit are commonly used as antiosteoporotic bisphosphonate examined Metabolites SKOV3 cells analyzed...
Abstract Though used widely in cancer therapy, paclitaxel only elicits a response fraction of patients. A strong determinant tumor is the state microtubule dynamic instability. However, whether manipulation this physiological process can be controlled to enhance has not been tested. Here, we show previously unrecognized role microtubule-associated protein CRMP2 inducing bundling through its carboxy terminus. This activity significantly decreased when FER tyrosine kinase phosphorylates at...
Similar to tumor-initiating cells (TICs), minimal residual disease (MRD) is capable of reinitiating tumors and causing recurrence. However, the molecular characteristics solid tumor MRD drivers their survival have remained elusive. Here we performed dense multiregion transcriptomics analysis paired biopsies from 17 ovarian cancer patients before after chemotherapy. We reveal that while share important signatures with TICs, they are also characterized by an adipocyte-like gene expression...
Over 50% of patients with high-grade serous carcinoma (HGSC) are homologous recombination proficient, making them refractory to platinum-based drugs and poly (ADP-ribose) polymerase (PARP) inhibitors. These often develop progressive resistance within 6 months after primary treatment tend die early, thus new therapies urgently needed. In this study, we comprehensively investigated tumor type by leveraging a combination machine learning analysis large published dataset newly developed...
Hereditary breast and ovarian cancer syndrome (HBOC) is traditionally associated with mutations in the BRCA1 BRCA2 genes, predominantly impacting breast, ovarian, pancreatic, prostate cancers. However, recent research suggests that these may also predispose carriers to a broader spectrum of malignancies, including biliary tract, cervical, colorectal, endometrial, esophageal, gastric This review presents findings from extensive datasets, significant study nationwide Japanese biobank examined...
High-grade serous carcinoma (HGSC), the most aggressive subtype of epithelial ovarian cancer, is strongly associated with hereditary breast and cancer (HBOC) syndrome primarily linked to germline BRCA1/2 pathogenic variants (PVs). The cumulative risks by age 70 years are 40% 18% for carriers BRCA1 BRCA2 PVs, respectively. Risk-reducing salpingo-oophorectomy (RRSO) a recommended preventive strategy that reduces risk more than 80% may improve overall survival. However, surgical menopause after...
In Japan, the rising incidence of hereditary breast and ovarian cancer syndrome (HBOC) follows partial insurance coverage introduced in 2020. Compared with general population (~11% lifetime risk), individuals HBOC face a significantly higher risk (48%-76%), often presenting at younger ages. BRCA1 mutations are linked to triple-negative cancer, whereas BRCA2 typically result luminal-type disease. Key management strategies include surveillance prophylactic surgery. Annual magnetic resonance...
Panel sequencing of susceptibility genes for hereditary breast and ovarian cancer (HBOC) syndrome has uncovered numerous germline variants; however, their pathogenic relevance ethnic diversity remain unclear. Here, we examined the prevalence variants among 568 Japanese patients with
The number of cases endometrial cancer has shown a tendency to increase in recent years. Endometrial originates from the endometrium and is classified, based on development mechanism, into types 1 2, which are responsive non-responsive estrogen, respectively, have significantly different gene expression profiles. Studies genes with abnormal identified multiple oncogenes, tumor suppressors, mismatch repair genes, apoptosis-associated levels hormone receptors DNA ploidy aneuploidy as...
Synchronous primary endometrial and ovarian cancers have been an important topic in clinical medicine because it is sometimes difficult to distinguish whether there are 2 tumors or a single tumor associated metastasis. In addition, although these recommended for either immunohistochemistry DNA mismatch repair (MMR) proteins microsatellite instability test the Bethesda guidelines as Lynch syndrome-associated cancers, few studies completed analyses. this study, we characterized...
Cervical cancer ranks high among the causes of female mortalities and is an important disease in developing developed countries. Current diagnosis cervical depends on colposcopy, pathological preoperative using methods, including magnetic resonance imaging computed tomography. Advanced has a poor prognosis. The tumor marker squamous cell carcinoma conventionally used for screening, but recent studies have revealed mechanisms carcinogenesis factors associated with prognosis cancer. These...
Aurora kinase A (AURKA) regulates the cell cycle checkpoint and maintains genomic integrity. AURKA is overexpressed in various malignant tumors its upregulation induces chromosomal instability, which leads to aneuploidy transformation. To investigate role of endometrial cancer, we evaluated association immunohistochemical expression with clinicopathological factors. Furthermore, examined effects inhibition by transfected siRNA HEC‑1B cells on colony‑forming ability, invasion migration...