A5030002766- Cancer, Lipids, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Metabolomics and Mass Spectrometry Studies
- Cancer, Hypoxia, and Metabolism
- Nutritional Studies and Diet
- Endometrial and Cervical Cancer Treatments
- Genetic factors in colorectal cancer
- Diet and metabolism studies
- Ovarian cancer diagnosis and treatment
- Birth, Development, and Health
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Gynecological conditions and treatments
- Lipid metabolism and biosynthesis
- Cancer Genomics and Diagnostics
- Liver Disease Diagnosis and Treatment
- Circular RNAs in diseases
- Urological Disorders and Treatments
- Pregnancy and preeclampsia studies
- Pharmaceutical Practices and Patient Outcomes
- Obesity, Physical Activity, Diet
- COVID-19 Impact on Reproduction
- Sleep and related disorders
- Medication Adherence and Compliance
- COVID-19 Clinical Research Studies
Keio University
2015-2024
Toyo University
2024
Keio University Hospital
2013-2021
Tokyo University of Science
2018
Kawasaki Municipal Hospital
2012-2013
Lynch syndrome is a hereditary ovarian cancer with prevalence of 0.9-2.7%. accounts for 10-15% cancers, while breast and 65-75% these cancers. The lifetime risk in families ~8%, which lower than colorectal endometrial not listed the Amsterdam Criteria II. More half sporadic cancers are diagnosed stage III or IV, but ≥80% I Ovarian mostly have non-serous histology different properties from those A screening method has yet to be established clinical studies prophylactic administration oral...
Background Cohort studies with metabolomics data are becoming more widespread, however, large-scale involving 10,000s of participants still limited, especially in Asian populations. Therefore, we started the Tsuruoka Metabolomics Study enrolling 11,002 community-dwelling adults Japan, and using capillary electrophoresis-mass spectrometry (CE-MS) liquid chromatography–mass spectrometry. The CE-MS method is highly amenable to absolute quantification polar metabolites, its reliability for...
This study aimed to examine the association between sleep duration and quality sarcopenia, assessed by factors such as low muscle mass (LMM), strength (LMS), physical performance (LPP) among older community-dwellers in Japan. In this cross-sectional study, a total of 2,069 (men, 902; women, 1,167) participants aged 65 80 years were included. Sarcopenia each function defined using definitions Asian Working Groups 2019. Sleep was stratified into three categories: short (<6 h), normal (6-8 long...
Aims: Nonalcoholic fatty liver disease (NAFLD) is known to be associated with atherosclerosis. This study focused on upstream changes in the process by which NAFLD leads The aimed confirm association between and cardio-ankle vascular index (CAVI), an indicator of subclinical atherosclerosis, explore metabolites involved both assessing 94 plasma polar metabolites.
Physical activity is known to be preventive against various non-communicable diseases. We investigated the relationship between daily physical level and plasma metabolites using a targeted metabolomics approach in population-based study.A total of 1,193 participants (male, aged 35 74 years) with fasting blood samples were selected from baseline survey cohort study. Information on activity, classified into four levels by quartile metabolic equivalent scores, sedentary behavior, defined as...
Drug repositioning is an alternative strategy redirecting existing drugs for new disease. We have previously reported antitumor effect of statins, antidyslipidemic drugs, on ovarian cancer in vitro and vivo. In this study, we investigated the effects other mevalonate pathway inhibitors mechanism from a metabolic perspective. The tumor cell growth were evaluated vitro. Bisphosphonates that inhibit are commonly used as antiosteoporotic bisphosphonate examined Metabolites SKOV3 cells analyzed...
Abstract Background Nosocomial spread of coronavirus disease 2019 (COVID-19) causes clusters infection among high-risk individuals. Controlling this is critical to reducing COVID-19 morbidity and mortality. We describe an outbreak in Keio University Hospital, Japan, its control propose effective measures. Methods When was suspected, immediate isolation thorough polymerase chain reaction (PCR) testing patients health care workers (HCWs) using in-house system, together with extensive contact...
The increasing incidence of obesity and diabetes due to changes in diet, earlier menarche, delayed menopause, late marriage, declining birth rate have resulted an increase the number endometrial cancer cases over last few decades. Although surgical therapy is sufficient for early cancer, there no effective patients with advanced recurrent cancer. oncogenic mechanism involves microsatellite instability (MSI) caused by dysfunction DNA mismatch repair genes 30% patients. Immune checkpoint...
Synchronous primary endometrial and ovarian cancers have been an important topic in clinical medicine because it is sometimes difficult to distinguish whether there are 2 tumors or a single tumor associated metastasis. In addition, although these recommended for either immunohistochemistry DNA mismatch repair (MMR) proteins microsatellite instability test the Bethesda guidelines as Lynch syndrome-associated cancers, few studies completed analyses. this study, we characterized...
Cervical cancer ranks high among the causes of female mortalities and is an important disease in developing developed countries. Current diagnosis cervical depends on colposcopy, pathological preoperative using methods, including magnetic resonance imaging computed tomography. Advanced has a poor prognosis. The tumor marker squamous cell carcinoma conventionally used for screening, but recent studies have revealed mechanisms carcinogenesis factors associated with prognosis cancer. These...
We studied the diagnostic performance of 18F-fluoro-2-deoxy-d-glucose-positron emission tomography/computed tomography in cervical and endometrial cancers with particular focus on lymph node metastases. Seventy patients cancer 53 were imaged before lymphadenectomy. evaluated using final pathological diagnoses as golden standard. calculated sensitivity, specificity, positive predictive value negative tomography. In cancer, results by cases 33.3, 92.7, 55.6 83.6%, respectively. When area...
The aim of the study was to investigate associations amino acids and other polar metabolites with metabolic syndrome (MetS) in postmenopausal women a lean Asian population.The participants were 1,422 female residents enrolled cohort from April August 2012. MetS defined according National Cholesterol Education Program Adult Treatment Panel III modified for Japanese women. Associations examined between 78 assayed fasting plasma samples using capillary electrophoresis-mass spectrometry....
Aurora kinase A (AURKA) regulates the cell cycle checkpoint and maintains genomic integrity. AURKA is overexpressed in various malignant tumors its upregulation induces chromosomal instability, which leads to aneuploidy transformation. To investigate role of endometrial cancer, we evaluated association immunohistochemical expression with clinicopathological factors. Furthermore, examined effects inhibition by transfected siRNA HEC‑1B cells on colony‑forming ability, invasion migration...
Branched-chain amino acids (BCAAs) play a key role in energy homeostasis.We aimed to investigate the association between plasma BCAA levels and dyslipidemia Japanese population without diabetes mellitus.This cross-sectional study included 4952 participants mellitus, enrolled Tsuruoka Metabolomic Cohort Study. Plasma were measured by capillary electrophoresis-mass spectrometry. Correlations lipid profiles evaluated sex-stratified multiple linear regression analyses, after adjusting for...
Metformin is a first-line drug used for the treatment of type 2 diabetes. Recently, metformin has been reported to reduce carcinogenic risk and inhibit tumor cell growth in glioma breast cancer. The anticancer action involves enhancement phosphorylation liver kinase B1, activation adenosine monophosphate‑activated protein inhibition mammalian target rapamycin, which reduces growth. anticipated exert antitumor effects gynecological cancer, its efficacy endometrial, ovarian cancer suggested...
Rapid lifestyle and dietary changes have contributed to a rise in the global prevalence of metabolic syndrome (MetS), which presents potential healthcare crisis, owing its association with an increased burden multiple cardiovascular neurological diseases. Prior work has identified role that genetic, lifestyle, environmental factors can play MetS. Metabolomics is important tool study alterations biochemical pathways intrinsic pathophysiology We undertook metabolomic MetS serum samples from...