A5041984936- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Organ and Tissue Transplantation Research
- Uterine Myomas and Treatments
- Genetic factors in colorectal cancer
- Organ Donation and Transplantation
- Cancer Genomics and Diagnostics
- Cancer Mechanisms and Therapy
- Global Cancer Incidence and Screening
- Transplantation: Methods and Outcomes
- Circular RNAs in diseases
- COVID-19 and healthcare impacts
- Cancer-related Molecular Pathways
- Multiple and Secondary Primary Cancers
- Microtubule and mitosis dynamics
- Reconstructive Surgery and Microvascular Techniques
- Neuroblastoma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Endometriosis Research and Treatment
- Economic and Financial Impacts of Cancer
- Bacterial Identification and Susceptibility Testing
- Reproductive Biology and Fertility
- Radiomics and Machine Learning in Medical Imaging
- Gestational Trophoblastic Disease Studies
- Chromatin Remodeling and Cancer
Keio University
2012-2024
Keio University Hospital
2016-2022
Tokyo Medical Center
2017
National Hospital Organization
2017
Kagoshima University
1966
Synchronous primary endometrial and ovarian cancers have been an important topic in clinical medicine because it is sometimes difficult to distinguish whether there are 2 tumors or a single tumor associated metastasis. In addition, although these recommended for either immunohistochemistry DNA mismatch repair (MMR) proteins microsatellite instability test the Bethesda guidelines as Lynch syndrome-associated cancers, few studies completed analyses. this study, we characterized...
Cervical cancer ranks high among the causes of female mortalities and is an important disease in developing developed countries. Current diagnosis cervical depends on colposcopy, pathological preoperative using methods, including magnetic resonance imaging computed tomography. Advanced has a poor prognosis. The tumor marker squamous cell carcinoma conventionally used for screening, but recent studies have revealed mechanisms carcinogenesis factors associated with prognosis cancer. These...
We studied the diagnostic performance of 18F-fluoro-2-deoxy-d-glucose-positron emission tomography/computed tomography in cervical and endometrial cancers with particular focus on lymph node metastases. Seventy patients cancer 53 were imaged before lymphadenectomy. evaluated using final pathological diagnoses as golden standard. calculated sensitivity, specificity, positive predictive value negative tomography. In cancer, results by cases 33.3, 92.7, 55.6 83.6%, respectively. When area...
Living donor surgery in organ transplantation should be performed a minimally invasive manner under conditions that are as safe possible. The objective of this study is to examine whether the procedure for using ovarian vein makes less cynomolgus monkey model potential living-donor uterus transplantation.Twenty-two female monkeys aged 6-9 years and with body weights 3.55 ± 1.28 kg were used study. Vessels tissues surrounding dissected while preserving uterine artery/vein. deep was venous...
Aurora kinase A (AURKA) regulates the cell cycle checkpoint and maintains genomic integrity. AURKA is overexpressed in various malignant tumors its upregulation induces chromosomal instability, which leads to aneuploidy transformation. To investigate role of endometrial cancer, we evaluated association immunohistochemical expression with clinicopathological factors. Furthermore, examined effects inhibition by transfected siRNA HEC‑1B cells on colony‑forming ability, invasion migration...
The objective of this study was to examine the allowable warm ischemic time and pathological changes due ischemia reperfusion injury in uterus cynomolgus monkey as a model for transplantation.Six female monkeys were used study. resected from vaginal canal connected through bilateral ovarian uterine arteries veins only. One animal control. In other five animals, vessels clamped 0.5, 1, 2, 4 8 h, respectively. Biopsy smooth muscle tissue corpus uteri performed after each subsequent 3 h....
Metformin is a first-line drug used for the treatment of type 2 diabetes. Recently, metformin has been reported to reduce carcinogenic risk and inhibit tumor cell growth in glioma breast cancer. The anticancer action involves enhancement phosphorylation liver kinase B1, activation adenosine monophosphate‑activated protein inhibition mammalian target rapamycin, which reduces growth. anticipated exert antitumor effects gynecological cancer, its efficacy endometrial, ovarian cancer suggested...
Cancer typically develops due to genetic abnormalities, but a single gene abnormality cannot completely account for the onset of cancer. The Genome Atlas (CGA) project was conducted cross-sectional genome-wide analysis numerous abnormalities in various types This approach has facilitated identification novel AT-rich interaction domain 1A mutations ovarian clear cell carcinoma, frequent tumor protein 53 (TP53) high-grade serous and Kirsten rat sarcoma B-rapidly accelerated fibrosarcoma...
How long is the allowable warm ischemic time of uterus and what morphological biochemical changes are caused by uterine ischemia/reperfusion injury in cynomolgus macaques?Warm ischemia macaques tolerated for up to 4 h reperfusion after no further changes.Uterus transplantation a potential option women with factor infertility. The humans non-human primates unknown.This experimental study included 18 female periodic menstruation.Animals were divided into six groups three monkeys each: control...
Abstract No study has reported an animal model of uterus transplantation (UTx) using cynomolgus macaques. We aimed to establish a surgical technique allogeneic UTx assuming the recovery from deceased donor in Four UTxs were performed female Donor surgeries comprised en bloc organs with iliac vessels on both sides, and/or abdominal aorta/vena cava after sufficient perfusion one femoral artery or external artery. Before perfusion, 150 mL whole blood was obtained for subsequent transfusion...
To compare the diagnostic characteristics of evaluation myometrial invasion (MI) retrospectively between preoperative magnetic resonance imaging (MRI) and intraoperative frozen sections.A retrospective study.University hospital.201 women diagnosed with endometrial carcinoma.All underwent MRI 111 them also section assessment. The final pathological was used as definitive diagnosis.In who sections (n = 111), accuracies detection MI deep (defined ≥50% invasion) were compared.The accuracy,...
As coronavirus disease 2019 (COVID-19) rages on, it is a challenging task to balance resources for treatment of COVID-19 and malignancy-based treatment. For the development optimal strategies, assessing conditions constrains in during pandemic pertinent. This study reported about nationwide survey conducted by Japan Society Gynecologic Oncology.We interviewed 265 designated training facilities state their clinical practice from time period between March December 2020. We asked facility...
To assess the impact of COVID-19 on cervical cancer screening.The Japanese Society Gynecologic Oncology launched Task Force surveyed municipalities in urban areas Japan. Questionnaires were sent to 20 ordinance-designated cities and 23 wards Tokyo metropolitan area Japan via telephone mail January 2021. An additional survey was conducted March April 2021, counted monthly checkups 2020 and, as a control data, number 2019. "The State Emergency" between 7 May 25, 2020, included 13 prefectures....
Endometrial cancer is a common gynecological malignant tumor in Western countries and its incidence has also been on the increase Asia. genetic abnormalities related to onset progression of malignancy endometrial membrane signaling system have identified developmental mechanism becoming elucidated. The identification molecules these led new potential treatment regimens for cancer, using molecular‑targeted drugs. current chemotherapy often causes systemic side effects that require...
We report two cases of anisakiasis lesions that were initially suspected to be recurrence gynecological cancer by positron emission tomography-computed tomography (PET-CT). Both extragastrointestinal is very rare. The first case was a patient with endometrial cancer. At 19 months after surgery, new low density area 2 cm in diameter liver segment 4 found on follow-up CT. In PET-CT, the lesion had abnormal 18fluoro-deoxyglucose (FDG) uptake elevation delayed phase, no other site showing FDG...
Abstract Background The number of cases novel coronavirus disease 2019 (COVID-19) in Japan have risen since the first case was reported on January 24, 2020, and 6225 infections been as June 30, 2020. On April 8, our hospital began screening patients via pre-admission reverse transcriptase-polymerase chain reaction (RT-PCR) for severe acute respiratory syndrome 2 (SARS-CoV-2) chest computed tomography (CT). Although no exhibited apparent pneumonia, treatment delay or changes plans were...
Abstract Objectives: The initial learning curve is a barrier to introducing robotic surgery. Evidence regarding appropriate simulation programs that allow for smooth introduction of gynecological surgery remains limited. Materials and Methods: We retrospectively analyzed 149 patients who underwent gynecologic diseases. Before their first procedure, the surgeons completed training program. Assistant also programs, including setup procedures manipulation arm. Results: mean (± standard...