A5043317390- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- Ovarian cancer diagnosis and treatment
- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- Genetic factors in colorectal cancer
- Cerebrovascular and Carotid Artery Diseases
- Endometriosis Research and Treatment
- Cervical Cancer and HPV Research
- Estrogen and related hormone effects
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- COVID-19 and healthcare impacts
- BRCA gene mutations in cancer
- Radiomics and Machine Learning in Medical Imaging
- Global Cancer Incidence and Screening
- Pregnancy and preeclampsia studies
- Atomic and Subatomic Physics Research
- Genetic Neurodegenerative Diseases
- Death, Funerary Practices, and Mourning
- Moyamoya disease diagnosis and treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiac electrophysiology and arrhythmias
- Menopause: Health Impacts and Treatments
Tokyo Medical Center
2023-2025
Keio University
2014-2024
National Hospital Organization
2023-2024
Eiju General Hospital
2021
Hakodate Central General Hospital
2013-2016
Hakodate National Hospital
1995-2009
Kawasaki Hospital
2005
Boston University
1998
Harvard University
1998
Massachusetts General Hospital
1998
Huntington9s disease (HD) is the result of an expanded (CAG) repeat in a gene on chromosome 4. A consequence defect may be progressive impairment energy metabolism. We previously showed increased occipital cortex lactate HD using localized <sup>1</sup>H spectroscopy. have now extended these studies to show almost threefold elevation 31 patients as compared with 17 normal control subjects(<i>p</i> < 10<sup>-11</sup>). The spectra three presymptomatic gene-positive were identical subjects...
Objective: Reports on the repeated administration of medroxyprogesterone acetate (MPA) for intrauterine recurrence after fertility-preserving therapy atypical endometrial hyperplasia (AEH) and early grade 1 endometrioid carcinoma (G1) are lacking.We aimed to clarify outcomes MPA in cases with against AEH/early G1.Methods: Patients AEH or stage IA well-differentiated without myometrial invasion who underwent first-line primary lesions were divided into initial treatment groups (162 82...
The present study was performed to clarify the significance of DNA methylation alterations during endometrial carcinogenesis. Genome-wide analysis and targeted sequencing tumor-related genes were using Infinium MethylationEPIC BeadChip Ion AmpliSeq Cancer Hotspot Panel v2, respectively, for 31 samples normal control tissue from patients without cancer 81 tissue. Principal component revealed that tumor had a profile distinct samples. Gene Ontology enrichment significant differences at 1034...
Abstract Aim To evaluate the safety and efficacy of scalp cooling in preventing chemotherapy‐induced alopecia among Japanese patients with gynecological cancer. Methods A retrospective study was conducted involving 16 cancer who underwent chemotherapy at our institution between January 2021 April 2024. The completion rate planned regimens, success (defined as hair loss ≤50%), volume recovery 8–12 weeks after chemotherapy, adverse events were assessed. Additionally, patient satisfaction...
Summary We investigated the dose-dependent cardiovascular effects of enalaprilat at different dosing times in two animal models hypertension. Blood pressure (BP) and heart rate (HR) were measured telemetrically 5 spontaneously hypertensive rats (SHR) transgenic (TGR) after intraperitoneal (i.p.) injection either 700 h or 1900 h. In SHR, beginning resting period, i.e., h, significantly reduced BP but did not influence HR. After was unchanged, whereas HR increased, which might have resulted...
As coronavirus disease 2019 (COVID-19) rages on, it is a challenging task to balance resources for treatment of COVID-19 and malignancy-based treatment. For the development optimal strategies, assessing conditions constrains in during pandemic pertinent. This study reported about nationwide survey conducted by Japan Society Gynecologic Oncology.We interviewed 265 designated training facilities state their clinical practice from time period between March December 2020. We asked facility...
To assess the impact of COVID-19 on cervical cancer screening.The Japanese Society Gynecologic Oncology launched Task Force surveyed municipalities in urban areas Japan. Questionnaires were sent to 20 ordinance-designated cities and 23 wards Tokyo metropolitan area Japan via telephone mail January 2021. An additional survey was conducted March April 2021, counted monthly checkups 2020 and, as a control data, number 2019. "The State Emergency" between 7 May 25, 2020, included 13 prefectures....
Objective Sentinel nodes (SNs) have been observed in several reports from Japan and overseas cases with endometrial cancer; however, no consensus has reached regarding the types of tracers or method their injection. A combination radioisotope (RI) dye is considered to be desirable. We assessed SN mapping using either near-infrared fluorescence imaging clarify a suitable cancer. Methods Patients were enrolled 92 patients diagnosed cancer having extrauterine metastasis by preoperative between...
The aim of this study was to establish criteria that would indicate whether fertility preservation therapy likely be safe for patients aged 40 years or less with endometrioid endometrial cancer based on their DNA methylation profile.Forty-nine fresh-frozen tissue samples from an initial cohort and 31 formalin-fixed paraffin-embedded a second were subjected genome-wide analysis using the Infinium MethylationEPIC BeadChip.Epigenomic clustering early-onset correlated widely used recurrence risk...
Interval debulking surgery (IDS) after neoadjuvant chemotherapy (NAC) is currently one of the preferred treatment options for advanced ovarian, fallopian tube or peritoneal cancer. This study was conducted to evaluate clinical efficacy and safety dose-dense paclitaxel plus carboplatin therapy (ddTC therapy) as NAC these cancers.A retrospective in 25 patients with Stage III/IV cancer who received ddTC NAC. For therapy, (80 mg/m2) administered intravenously on Days 1, 8 15 (AUC 6.0 mg/ml ×...
Abstract There has been a rapid advance in germline multigene panel testing by next-generation sequencing, and it is being widely used clinical settings. A 56-year-old woman suspected of having Lynch syndrome was identified as BRCA2 pathogenic variant carrier testing. The patient diagnosed with endometrial cancer at the age 39 years, total laparoscopic hysterectomy bilateral salpingectomy were performed 49 years; however, oophorectomy not that time. As she had family history colorectal...
Abstract Substantial numbers of variants unknown significance (VUSs) have been identified in BRCA1 / 2 through genetic testing, which poses a significant clinical challenge because the contribution these VUSs to cancer predisposition has not yet determined. Here, we report 10 Japanese patients from seven families with breast or ovarian harboring BRCA2 c.7847C>T (p.Ser2616Phe) variant that was interpreted as VUS. This recurs only Japan and reported global general population databases. A...
Bilateral salpingo-oophorectomy (BSO) is a risk factor for osteoporosis. Previous studies have reported an association between genetic polymorphisms and the of developing However, relationship osteoporosis in Japanese women treated with BSO not well understood. To improve quality life post-BSO patients, it important to determine factors that influence their The aim this study was investigate gene variations estrogen metabolism-related genes surgically menopausal which may life.This included...
We previously reported an association between dyslipidemia and endometrial cancers. Osteoporosis is also to relate with some A common etiologic event has been proposed osteoporosis. However, the pattern of interrelationships among dyslipidemia, osteoporosis cancer not well understood. To improve quality life survivors, these relationships should be determined. This study included 179 Japanese menopausal women who underwent bilateral salpingo-oophorectomy, including 114 incident 65 without...
Although cervical conization is considered a standard treatment for intraepithelial neoplasia (CIN) 2/3, laser ablation can compensate the disadvantages of former. CO
In this study, we collected data over 8 years (2012-2019) from the Japan Society of Obstetrics and Gynecology (JSOG) tumor registry to determine status endometrial cancer in Japan, analyzed detailed clinicopathological factors.
The VIBE method has been developed imaging also holds its breath in an abdomen, and to do three-dimensional T1WI possible time gradient echo sequence, applied dynamic study mainly planning for reduction using interpolation partial fourier. We considered the condition whole brain as high resolution image VIBE. Even if base matrix was maintained when fourier were used too much excessively by Phantom experiment, of MPR fell. There a limit therefore maintain voxel. SNR fell FA increase...
Abstract Aim Tamoxifen (TAM) is widely used in adjuvant endocrine therapy for invasive breast cancer as a selective estrogen modulator, but this treatment has risk of developing endometrial malignancy. However, hysteroscopic findings during or after TAM are unclear. The aim study to examine the association between patterns and malignant histological with TAM. Methods subjects were patients who received surgery underwent hysteroscopy at our institution from January 2016 December 2019....
Vessel wall imaging using radial scanning does not use a blood flow suppression pulse with gated acquisition. It has been proposed that there may be void effect if the rate is slow; however, this yet to empirically tested. To clarify relationship between signal intensity of vessel lumen and in phantom, we investigated usefulness at 3.0 tesla (T). We measured while changing phantom. Radial 1.5 T showed sufficient voids above medium rates. There was no significant difference carotid artery...
The purpose of this study was to optimize scan parameters for evaluation carotid plaque characteristics by k-space trajectory (radial method), using a custom-made phantom. phantom composed simulated sternocleidomastoid muscle and four types plaque. effect chemical shift artifact compared T1 weighted images (T1WI) the obtained with without fat suppression, two (the radial method Cartesian method). ratio signal intensity hematoma, blood (including heparin), lard, mayonnaise among various...