A5103070848- Hematopoietic Stem Cell Transplantation
- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Viral-associated cancers and disorders
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Neutropenia and Cancer Infections
- Polyomavirus and related diseases
- Immune Cell Function and Interaction
- CNS Lymphoma Diagnosis and Treatment
- Fungal Infections and Studies
- Eosinophilic Disorders and Syndromes
- Transplantation: Methods and Outcomes
- Histone Deacetylase Inhibitors Research
- Antifungal resistance and susceptibility
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Genomic variations and chromosomal abnormalities
- CAR-T cell therapy research
- Acute Lymphoblastic Leukemia research
- Liver Disease and Transplantation
- Streptococcal Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Cutaneous lymphoproliferative disorders research
Toranomon Hospital
2016-2025
Osaka University Hospital
2024
Osaka University
1988-2024
Saitama Cancer Center
2020-2023
Kobe City Nishi-Kobe Medical Center
2017-2018
Kobe Medical Center
2006-2016
Universidade de São Paulo
2016
The University of Tokyo
2003-2012
Fukushima Medical University
2001-2009
Shiga University of Medical Science
1992-2009
Signaling through the Notch1 receptor has a pivotal role in early thymocyte development. Gain of function results development T-cell acute lymphoblastic leukemia number mouse experimental models, and activating mutations deregulate signaling majority human leukemias. Notch2, another member Notch gene family, is preferentially expressed mature B cells essential for marginal zone B-cell generation. Here, we report that 5 63 (approximately 8%) diffuse large lymphomas, subtype have Notch2...
Microsatellites are repeats of 1- to 6-bp units, and approximately 10 million microsatellites have been identified across the human genome. vulnerable DNA mismatch errors thus used detect cancers with repair deficiency. To reveal mutational landscape microsatellite repeat regions at genome level, we analyzed 20.1 billion in 2717 whole genomes pan-cancer samples 21 tissue types. First, developed a new insertion deletion caller (MIMcall) that takes into consideration error patterns different...
Clostridium butyricum, a probiotic commonly prescribed in Asia, most notably as MIYA-BM (Miyarisan Pharmaceutical Co., Ltd.; https://www.miyarisan.com), occasionally leads to bacteremia. The prevalence and characteristics of C. butyricum bacteremia its bacteriologic genetic underpinnings remain unknown. We retrospectively investigated patients admitted Osaka University Hospital during September 2011-February 2023. Whole-genome sequencing revealed 5 (0.08%) cases among 6,576 case-patients who...
AML1 (RUNX1) is one of the most frequently disrupted genes in human leukemias. encodes transcription factors, which play a pivotal role hematopoietic differentiation, and their inappropriate expression associated with leukemic transformation cells. Previous studies demonstrated that cofactor p300 binds to C-terminal region stimulates AML1-dependent during myeloid cell differentiation. Here, we report specifically acetylated by vitro. Mutagenesis analyses reveal acetylates at two conserved...
Abstract Formalin-fixed, paraffin-embedded (FFPE) material tends to yield degraded DNA and is thus suboptimal for use in many downstream applications. We describe an integrated analysis of genotype, loss heterozygosity (LOH), copy number derived from FFPE tissues using oligonucleotide microarrays containing over 500K single nucleotide polymorphisms. A prequalifying PCR test predicted the performance on better than age sample. Although genotyping efficiency reliability were reduced when...
A pilot study of a novel, reduced-toxicity, myeloablative conditioning regimen using intravenous busulfan 12.8 mg/kg, fludarabine 180 mg/m2, and melphalan 80 mg/m2 for single cord blood transplantation (CBT) was conducted at our institution. Fifty-one patients with myeloid malignancies not in remission were included this study. Their median age 59 years (range, 19 to 70 years), hematopoietic cell transplantation–specific comorbidity index score 3. With observation period 39.6 months 24.3...
This is the first report of therapy-related mixed-phenotype acute leukemia (MPAL) characterized by B-cell, T-cell, and myeloid lineage phenotypes. A 68-year-old man, who was in complete remission after chemoradiotherapy for recurrent esophageal cancer, developed bacterial pneumonia with increasing blasts peripheral blood, a subsequent bone marrow biopsy revealed 85.2% blasts. flow cytometric analysis cytMPO+, CD19+, cytCD22+, cytCD3+ markers. The patient diagnosed MPAL (B/T/myeloid lineage)....
Abstract Background: Endoscopic ultrasonography‐guided fine‐needle aspiration (EUS‐FNA) can now provide a cytopathological diagnosis of underlying pancreatic malignancy with higher success rates than endoscopic retrograde pancreatography (ERP). To determine the significance EUS‐FNA for mass without biliary stricture, value obtained by was retrospectively compared that ERP, and complications associated these procedures evaluated. Methods: Eighty‐three patients who were suspected to have...
Abstract Primary effusion-based lymphoma (EBL) presents as a malignant effusion in body cavity. The clinicopathologic features and prognosis of primary human herpesvirus 8 (HHV8)–negative EBL remain unclear. We therefore conducted retrospective study 95 patients with EBL, regardless HHV8 status, Japan. Of 69 tested for HHV8, total 64 were negative. median age HHV8-negative at diagnosis was 77 years (range, 57-98 years); all 58 negative HIV. most commonly diagnosed pleural (77%). Expression...
Abstract The lymphocyte-specific Cas family protein Cas-L (Crk-associated substrate lymphocyte type) has been implicated to function in movement, mediated mainly by integrin signaling. However, its physiological role is poorly understood. In this study we analyzed the of lymphocytes using gene-targeted mice. mutant mice showed a deficit marginal zone B (MZB) cells and decrease cell number secondary lymphoid organs. An insufficient chemotactic response perturbed adhesion were observed...
Abstract Barrett's esophagus (BE) is a metaplastic condition caused by chronic gastroesophageal reflux which represents an early step in the development of esophageal adenocarcinoma (EAC). Single‐nucleotide polymorphism microarray (SNP‐chip) analysis novel, precise, high‐throughput approach to examine genomic alterations neoplasia. Using 250K SNP‐chips, we examined neoplastic progression BE EAC, studying 11 matched sample sets: 6 sets normal (NE), and 4 NE 1 EAC. Six (60%) 10 total samples...
To clarify clinical and microbiological features of invasive group B Streptococcus (GBS) disease in Japan.This was a retrospective review for the period 1998-2007 patients across all age groups Nishi-Kobe Medical Center. Invasive GBS defined as isolation from normally sterile site or skin/soft tissues.Six infant 52 adult cases infection were identified. Diagnosis limited to bacteremia meningitis infants, but varied widely adults with tissue infections being common. The overall fatality rate...
The impact of anti-HLA antibodies, except for donor-specific anti-HLA-A, -B, -DRB1 on engraftment was retrospectively evaluated in 175 single cord blood transplantations (CBT). Patients and donors had been typed at HLA-A, antigens, antibodies screened before transplantation to avoid the use (CB) units with corresponding antigens. median age 59 (range, 17 74) years. Overall, 61% were male, 89% high-risk disease status, 77% received myeloablative conditioning regimens, over 80% heavily...
ABSTRACT Limited data are available on micafungin breakthrough fungemia (MBF), that develops administration of micafungin, in patients with hematological disorders. We reviewed medical and microbiological records disorders who developed MBF between January 2008 June 2015. A total 39 were identified, Candida (30 strains) non- (9 fungal species recognized as causative strains. Among 35 stored strains, parapsilosis (14 strains), Trichosporon asahii (7 glabrata (5 other identified by sequencing....