A5085000681- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Hematopoietic Stem Cell Transplantation
- Viral-associated cancers and disorders
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- CNS Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Polyomavirus and related diseases
- T-cell and Retrovirus Studies
- CAR-T cell therapy research
- Cytomegalovirus and herpesvirus research
- Parvovirus B19 Infection Studies
- Histiocytic Disorders and Treatments
- Chronic Myeloid Leukemia Treatments
- Cell death mechanisms and regulation
- Signaling Pathways in Disease
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Genetic factors in colorectal cancer
- Lung Cancer Treatments and Mutations
- RNA Interference and Gene Delivery
- Immune Response and Inflammation
- Glioma Diagnosis and Treatment
Kawasaki Medical School
2018-2025
Shinshu University
2017-2023
Okayama Prefecture
2000-2020
Okayama University
2010-2019
Okayama University Hospital
2009-2018
Aichi Cancer Center
2001-2016
Niigata University
2016
University of Split
2016
The University of Queensland
2016
University Hospital Cologne
2008-2009
Multicentric Castleman disease (MCD) describes a heterogeneous group of disorders involving systemic inflammation, characteristic lymph node histopathology, and multi-organ dysfunction because pathologic hypercytokinemia. Whereas Human Herpes Virus-8 (HHV-8) drives the hypercytokinemia in cohort immunocompromised patients, etiology HHV-8-negative MCD is idiopathic (iMCD). Recently, limited series iMCD cases Japan sharing constellation clinical features, including thrombocytopenia (T),...
IgG4‐related disease is a recently proposed clinical entity with several unique clinicopathological features. Ocular adnexal disease, however, has not well been clarified. The purpose of the present study was to examine 21 patients (10 men, 11 women; age range, 39–86 years) ocular disease. In 17 out (81%), lacrimal glands were involved and bilateral gland swelling frequently observed ( n = 12; 70.6%). contrast, conjunctiva in any patient. Histology uniform marked lymphoplasmacytic...
By studying mice in which the Nfatc1 gene was inactivated bone marrow, spleen, or germinal center B cells, we show that NFATc1 supports proliferation and suppresses activation-induced cell death of splenic cells upon receptor (BCR) stimulation. BCR triggering leads to expression NFATc1/αA, a short isoform NFATc1, cells. ablation impaired Ig class switch IgG3 induced by T cell–independent type II antigens, as well IgG3+ plasmablast formation. Mice bearing NFATc1−/− harbor twofold more...
The superiority of the pediatric protocol for adolescents with acute lymphoblastic leukemia (ALL) has already been demonstrated, however, its efficacy in young adults remains unclear. ALL202-U was conducted to examine and feasibility a (AYAs) BCR-ABL-negative ALL. Patients aged 15-24 years (n=139) were treated same used B-ALL. primary objective this study assess disease-free survival (DFS) rate secondary aims toxicity, complete remission (CR) overall (OS) rate. CR 94%. 5-year DFS OS rates...
We report the identification of two novel minor histocompatibility antigens (mHAgs), encoded by separate single nucleotide polymorphisms on a gene, BCL2A1, and restricted human leukocyte antigen (HLA)-A*2402 (the most common HLA-A allele in Japanese) B*4403, respectively. Two cytotoxic T lymphocyte (CTL) clones specific for these mHAgs were first isolated from distinct recipients after hematopoietic cell transplantation. Both lyse only normal malignant cells within lineage. To localize gene...
Abstract Chronic graft-versus-host disease (GVHD) is a major cause of late death and morbidity after allogeneic hematopoietic cell transplantation, but its pathogenesis remains unclear. We investigated the role programmed death-1 (PD-1) pathway in chronic GVHD using well-defined mouse model B10.D2 (H-2d) donor to BALB/c recipients. PD-1 expression on T cells was upregulated continuously development, whereas PD-L1 host tissues transiently declined basal levels posttransplant period. Blockade...
Abstract Multicentric Castleman disease (MCD) is a heterogeneous lymphoproliferative disorder. It characterized by inflammatory symptoms, and interleukin (IL)-6 contributes to the pathogenesis. Human herpesvirus 8 (HHV-8) often drives hypercytokinemia in MCD, although etiology of HHV-8-negative MCD idiopathic (iMCD). A distinct subtype iMCD that shares constellation clinical features including thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis (R), organomegaly (O) has been...
Abstract The development of rapid, efficient, and safe methods for generating Ag-specific T cells is necessary the clinical application adoptive immunotherapy. We show that B stimulated with CD40 ligand IL-4 (CD40-B cells) can be efficiently transduced retroviral vectors encoding a model Ag, CMV tegument protein pp65 gene, maintain high levels costimulatory molecules after gene transfer. CTL lines specific were readily generated in all four healthy CMV-seropositive donors by stimulating...
Recently, atypical Castleman's disease (CD) was reported in Japan. This is considered as TAFRO syndrome or non-idiopathic plasmacytic lymphadenopathy (IPL), a constellation of clinical symptoms, namely, thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly without hyper-γ-globulinemia. Histopathologically, this similar to hyaline vascular (HV)-type CD. Here, we present 43-year-old Japanese woman meeting the criteria who successfully treated with combined corticosteroid...
The number of elderly patients with diffuse large B cell lymphoma (DLBCL) continues to increase but the data regarding autologous stem transplantation (ASCT) for are limited. We analyzed 484 patients, ages 60 years or over, diagnosed relapsed/refractory DLBCL who received ASCT from 1993 2010 in Japan Society Hematopoietic Cell Transplantation database. Median age was 64 (range, 78). To evaluate impact at ASCT, were classified into 3 groups: those between 64, 65 69, and 70 over. Overall...
Background: Follicular lymphomas occasionally arise in the extra-nodal organs and are frequently found duodenum. They often localised tumours with multiple polyps around ampulla of Vater. Aims: To examine a IgH/bcl-2 hybrid gene VH to investigate nature lymphoma cells how they differ from nodal follicular MALT lymphomas. Methods: Of 40 patients reported previously, 35 duodenal were studied detail respect clinicopathological characteristics. Results: 37/40 clinical stage I (n = 30) or II 7)....
MicroRNAs (miRNAs) play important roles in regulating post-transcriptional gene repression a variety of immunological processes. In particular, much attention has been focused on their regulatory T (Treg) cells which are crucial for maintaining peripheral tolerance and controlling cell responses. Recently, we established novel type human Treg line, termed HOZOT, multifunctional exhibiting CD4+CD8+ phenotype. this study, performed miRNA profiling to identify signature miRNAs therein...
The expression of cytotoxic granule-associated proteins has been reported in some T-cell or natural killer (NK)-cell lymphomas mostly extranodal origin, but rarely nodal origin except for anaplastic large cell lymphoma (ALCL) and Hodgkin's disease (HD). This study analyzed 66 expressing intracellular antigen-1 (TIA-1) and/or granzyme B to characterize the clinicopathologic spectrum these neoplasms. Four main groups could be delineated. first group consisted p80/anaplastic kinase...