A5052011937- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- Lung Cancer Research Studies
- Cancer-related molecular mechanisms research
- BRCA gene mutations in cancer
- Cancer-related Molecular Pathways
- Circular RNAs in diseases
- Endometriosis Research and Treatment
- Cancer, Hypoxia, and Metabolism
- Multiple and Secondary Primary Cancers
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- PI3K/AKT/mTOR signaling in cancer
- Cancer therapeutics and mechanisms
- Microtubule and mitosis dynamics
- Metabolism, Diabetes, and Cancer
- Gestational Trophoblastic Disease Studies
- Glycosylation and Glycoproteins Research
- Colorectal Cancer Screening and Detection
- Epigenetics and DNA Methylation
- Reproductive System and Pregnancy
- Gynecological conditions and treatments
Keio University
2013-2023
Keio University Hospital
2011-2020
Obayashi (Japan)
2019
Osaka City General Hospital
2009-2012
Kindai University
2009
Lynch syndrome is a hereditary ovarian cancer with prevalence of 0.9-2.7%. accounts for 10-15% cancers, while breast and 65-75% these cancers. The lifetime risk in families ~8%, which lower than colorectal endometrial not listed the Amsterdam Criteria II. More half sporadic cancers are diagnosed stage III or IV, but ≥80% I Ovarian mostly have non-serous histology different properties from those A screening method has yet to be established clinical studies prophylactic administration oral...
Drug repositioning is an alternative strategy redirecting existing drugs for new disease. We have previously reported antitumor effect of statins, antidyslipidemic drugs, on ovarian cancer in vitro and vivo. In this study, we investigated the effects other mevalonate pathway inhibitors mechanism from a metabolic perspective. The tumor cell growth were evaluated vitro. Bisphosphonates that inhibit are commonly used as antiosteoporotic bisphosphonate examined Metabolites SKOV3 cells analyzed...
Cervical cancer is the most common gynecological malignancy in world; however, survival rates of advanced-stage and recurrent cervical patients remain poor. The multifaced protein insulin-like growth factor 2 receptor (IGF2R) has various ligands, represented as IGF-2 mannose-6-phosphate (M6P)-tagged proteins. Regarding its antagonistic activity an IGF1R signal, IGF2R currently considered a tumor suppressor gene, whereas significance M6P still unclear. Here, on basis transcriptome analysis...
Objective: With the emerging significance of genetic profiles in management endometrial cancer, identification tumor-driving genes with prognostic value is a pressing need.The LAMC1 gene, encoding laminin subunit gamma 1 (LAMC1) protein, has been reported to be involved progression various malignant tumors.In this study, we aimed investigate role cancer and elucidate underlying mechanism.Methods: We evaluated immunohistochemical expression atypical hyperplasia cancer.Within cases, analyzed...
Paclitaxel/carboplatin chemotherapy for cancer (TC therapy) exhibits neurotoxicity and causes peripheral neuropathy at a high frequency, which is difficult to cope with. In this study, we investigated the efficacy of Goshajinkigan, traditional Japanese herbal medicine, TC therapy-induced neuropathy. The subjects included in our study were patients with ovarian or endometrial who underwent therapy developed randomly divided into Group A, comprising 14 (vitamin B12 treatment), B, 15 +...
The increasing incidence of obesity and diabetes due to changes in diet, earlier menarche, delayed menopause, late marriage, declining birth rate have resulted an increase the number endometrial cancer cases over last few decades. Although surgical therapy is sufficient for early cancer, there no effective patients with advanced recurrent cancer. oncogenic mechanism involves microsatellite instability (MSI) caused by dysfunction DNA mismatch repair genes 30% patients. Immune checkpoint...
The number of cases endometrial cancer has shown a tendency to increase in recent years. Endometrial originates from the endometrium and is classified, based on development mechanism, into types 1 2, which are responsive non-responsive estrogen, respectively, have significantly different gene expression profiles. Studies genes with abnormal identified multiple oncogenes, tumor suppressors, mismatch repair genes, apoptosis-associated levels hormone receptors DNA ploidy aneuploidy as...
Synchronous primary endometrial and ovarian cancers have been an important topic in clinical medicine because it is sometimes difficult to distinguish whether there are 2 tumors or a single tumor associated metastasis. In addition, although these recommended for either immunohistochemistry DNA mismatch repair (MMR) proteins microsatellite instability test the Bethesda guidelines as Lynch syndrome-associated cancers, few studies completed analyses. this study, we characterized...
We studied the diagnostic performance of 18F-fluoro-2-deoxy-d-glucose-positron emission tomography/computed tomography in cervical and endometrial cancers with particular focus on lymph node metastases. Seventy patients cancer 53 were imaged before lymphadenectomy. evaluated using final pathological diagnoses as golden standard. calculated sensitivity, specificity, positive predictive value negative tomography. In cancer, results by cases 33.3, 92.7, 55.6 83.6%, respectively. When area...
Aurora kinase A (AURKA) regulates the cell cycle checkpoint and maintains genomic integrity. AURKA is overexpressed in various malignant tumors its upregulation induces chromosomal instability, which leads to aneuploidy transformation. To investigate role of endometrial cancer, we evaluated association immunohistochemical expression with clinicopathological factors. Furthermore, examined effects inhibition by transfected siRNA HEC‑1B cells on colony‑forming ability, invasion migration...
Incidence of lymph node metastasis is relatively high even in early-stage epithelial ovarian cancers (EOC). Lymphadenectomy important the surgical treatment EOC; however, exact role lymphadenectomy management EOC remains unclear. In this study, we evaluated stages I and II patients.Seventy-nine patients with stage I/II underwent initial surgery, 68 received adjuvant platinum taxane chemotherapy after surgery at Keio University Hospital. The were respect to age diagnosis, clinical stage,...
Metformin is a first-line drug used for the treatment of type 2 diabetes. Recently, metformin has been reported to reduce carcinogenic risk and inhibit tumor cell growth in glioma breast cancer. The anticancer action involves enhancement phosphorylation liver kinase B1, activation adenosine monophosphate‑activated protein inhibition mammalian target rapamycin, which reduces growth. anticipated exert antitumor effects gynecological cancer, its efficacy endometrial, ovarian cancer suggested...
The Werner (WRN) gene codes for a DNA helicase that contributes to genomic stability and has been identified as the responsible progeria. Recent studies have shown reduced WRN expression due aberrant hypermethylation in cancer cells. Furthermore, is thought affect sensitivity topoisomerase I inhibitors therapy. In this study, we examined relationship between of cervical cells anticancer drugs. was extracted from samples 22 patients with primary 6 human cancer-derived cell lines. Aberrant...
Cancer typically develops due to genetic abnormalities, but a single gene abnormality cannot completely account for the onset of cancer. The Genome Atlas (CGA) project was conducted cross-sectional genome-wide analysis numerous abnormalities in various types This approach has facilitated identification novel AT-rich interaction domain 1A mutations ovarian clear cell carcinoma, frequent tumor protein 53 (TP53) high-grade serous and Kirsten rat sarcoma B-rapidly accelerated fibrosarcoma...