A5065544044- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Neuroendocrine Tumor Research Advances
- Chromatin Remodeling and Cancer
- Cervical Cancer and HPV Research
- Cancer Mechanisms and Therapy
- Uterine Myomas and Treatments
- Cytomegalovirus and herpesvirus research
- Inflammatory Bowel Disease
- Pancreatic and Hepatic Oncology Research
- Endometriosis Research and Treatment
- Genetic factors in colorectal cancer
- Mycobacterium research and diagnosis
- Cancer, Lipids, and Metabolism
- Gastrointestinal Tumor Research and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Streptococcal Infections and Treatments
- Lung Cancer Research Studies
- Immunodeficiency and Autoimmune Disorders
- RNA modifications and cancer
- MRI in cancer diagnosis
Chang Gung Memorial Hospital
2016-2025
Central South University
2010-2025
Second Xiangya Hospital of Central South University
2021-2025
University of Alabama at Birmingham
2010-2024
Memorial Hospital of South Bend
2009-2024
Linkou Chang Gung Memorial Hospital
2010-2024
Chang Gung University
2015-2024
Chengdu University of Traditional Chinese Medicine
2024
Columbia University
2024
Capital Region of Denmark
2023
Endometriosis, defined as the presence of ectopic endometrial stroma and epithelium, affects approximately 10% reproductive-age women can cause pelvic pain infertility. Endometriotic lesions are considered to be benign inflammatory but have cancerlike features such local invasion resistance apoptosis.
BackgroundUterine cancer is the fourth most common malignancy in women, and uterine serous carcinoma aggressive subtype. However, molecular pathogenesis of largely unknown. We analyzed genomes samples to better understand genetic characteristics this cancer.
Radiotherapy (RT) of colorectal cancer (CRC) can prime adaptive immunity against tumor-associated antigen (TAA)-expressing CRC cells systemically. However, abscopal tumor remissions are extremely rare, and the postirradiation immune escape mechanisms in remain elusive. Here, we found that irradiated used ATR-mediated DNA repair signaling pathway to up-regulate both CD47 PD-L1, which through engagement SIRPα PD-1, respectively, prevented phagocytosis by antigen-presenting thereby limited TAA...
The clonal relationship between ovarian high-grade serous carcinoma (HGSC) and its presumed precursor lesion, tubal intraepithelial (STIC), has been reported. However, when analyzing patients with concurrent the extensive tissues present at diagnosis may have effaced natural habitat of clone(s), obscuring tumor evolutionary history, or disseminated to anatomically adjacent fimbriae ends, masquerading as lesions. To circumvent these limitations, we analyzed genomic landscape incidental...
The chromatin remodeling gene, ARID1A , has been implied as a tumor suppressor, and its somatic inactivating mutations occur in wide variety of human cancers, most frequently ovarian uterine endometrioid clear cell carcinomas. Tumors with also harbor PTEN or PIK3CA mutations, suggesting their collaboration tumorigenesis. Here, we used conditional knockout mouse model which Arid1a Pten were deleted either individually combination the surface epithelium. After 6 months, 59.1% mice double...
Up-regulated expression of telomerase reverse transcriptase (TERT) and subsequent maintenance telomere length are essential in tumour development. Recent studies have implicated somatic gain-of-function mutations at the TERT promoter as one mechanisms that promote transcriptional activation TERT; however, it remains unclear whether this genetic abnormality is prevalent gynaecological neoplasms. We performed mutational analysis a total 525 cancers, correlated with clinicopathological...
The Notch3 signaling pathway is thought to play a critical role in cancer development, as evidenced by the amplification and rearrangement observed human cancers. However, molecular mechanism which contributes tumorigenesis largely unknown. In an effort identify modulators of pathway, we screened for Notch3-intracellular domain (N3-ICD) interacting proteins using proteome microarray. Pathway analysis interactome demonstrated that ubiquitin C was hub top functional network, suggesting...
Abstract The pathological identification of lymph node (LN) metastasis is demanding and tedious. Although convolutional neural networks (CNNs) possess considerable potential in improving the process, ultrahigh-resolution whole slide images hinders development a clinically applicable solution. We design an artificial-intelligence-assisted LN assessment workflow to facilitate routine counting metastatic LNs. Unlike previous patch-based approaches, our proposed method trains CNNs by using...
The present study assessed the impact of retrieval >25 lymph nodes (LNs) on survival outcome patients with advanced gastric cancer after curative-intent gastrectomy.A total 5,386 who had undergone curative gastrectomy for from 1994 to 2011 were enrolled. clinicopathological parameters and overall (OS) analyzed according number LNs examined (≤15, n = 916; 16-25, 1,458; >25, 3,012).The percentage retrieved increased 2011. Patients in LN group more likely have a larger tumor size, poorer...
Statins are among the most frequently prescribed drugs because of their efficacy and low toxicity in treating hypercholesterolemia. Recently, statins have been reported to inhibit proliferative activity cancer cells, especially those with TP53 mutations. Because mutations occur almost all ovarian high-grade serous carcinoma (HGSC), we determined whether suppressed tumor growth animal models cancer.Two mouse were used. The first one was a genetically engineered model, mogp-TAg, which promoter...
Abstract The derivation of ovarian intestinal‐type mucinous tumours is not well established. Some are derived from teratomas but the origin majority clear. It has been recently proposed that non‐germ cell group may be Brenner tumours, as association a tumour with frequently observed. In order to explore histogenesis these neoplasms, we undertook clonality analysis two components ten combined and using human androgen receptor gene ( HUMARA ) assay. All eight informative cases showed...
Streptococcus mutans and Candida albicans are frequently co-isolated from dental plaque of children with early childhood caries (ECC) only rarely found in without ECC, suggesting that these species interact a manner contributes to the pathogenesis ECC. Previous studies have demonstrated glucans produced by S. crucial for promoting formation biofilm cariogenicity C. albicans; however, it is unclear how non-glucan factors contribute increased presence albicans. In this study we examined role...
Intrahepatic cholangiocarcinoma is a fatal primary liver cancer resulting from diagnosis at an advanced stage. Understanding the mechanisms of drug resistance and metastasis may improve disease prognosis. Enhanced aldehyde dehydrogenase (ALDH) activity suggested to be associated with increased metastasis. This study aims investigate roles ALDH isoforms in cholangiocarcinoma.Aldefluor assays, RT-PCR, Western blot analysis were used identify major contributing Aldefluor human cell lines. We...
Objective: With the emerging significance of genetic profiles in management endometrial cancer, identification tumor-driving genes with prognostic value is a pressing need.The LAMC1 gene, encoding laminin subunit gamma 1 (LAMC1) protein, has been reported to be involved progression various malignant tumors.In this study, we aimed investigate role cancer and elucidate underlying mechanism.Methods: We evaluated immunohistochemical expression atypical hyperplasia cancer.Within cases, analyzed...
Cytomegalovirus (CMV) infection of the gastrointestinal (GI) tract can be fatal. However, very few studies have provided comprehensive analyses and specified differences in symptoms observed different parts GI tract. This study aimed to comprehensively analyze clinical manifestations management CMV disease. retrospective cohort enrolled patients who had diseases proved by immunohistochemistry stain from pathology database a 4000-bed tertiary medical center between January 2000 May 2021. The...