A5100637445- Glycosylation and Glycoproteins Research
- Cell death mechanisms and regulation
- Fluorine in Organic Chemistry
- Biocrusts and Microbial Ecology
- Catalytic Cross-Coupling Reactions
- Tardigrade Biology and Ecology
- Adhesion, Friction, and Surface Interactions
- Neurobiology and Insect Physiology Research
- Carbohydrate Chemistry and Synthesis
- Lubricants and Their Additives
- Gear and Bearing Dynamics Analysis
- Organoboron and organosilicon chemistry
- Catalytic C–H Functionalization Methods
- Metabolism, Diabetes, and Cancer
- Chemical Synthesis and Analysis
- Protein Kinase Regulation and GTPase Signaling
- Tribology and Lubrication Engineering
- Chemical Synthesis and Reactions
- Insect Utilization and Effects
- Synthetic Organic Chemistry Methods
- Tribology and Wear Analysis
- Polar Research and Ecology
- Force Microscopy Techniques and Applications
- Cancer-related Molecular Pathways
- Teleoperation and Haptic Systems
Bristol-Myers Squibb (Japan)
2024
Keio University
2014-2023
Aisin (United States)
2022
Tokyo Metropolitan University
2020-2022
Material (Belgium)
2022
Takeda (Japan)
2017-2021
Tokyo Metropolitan Geriatric Hospital
2016-2018
Toyota Motor Corporation (Switzerland)
2005-2017
Toyota Motor Corporation (Japan)
2007-2017
Nagoya University
1983-2016
Abstract The transition metal-catalyzed reactions of organometallics with organic halides have been extensively studied to prove a new approach selective formation carbon-carbon bonds. Recently, such coupling haloarenes aryl magnesium1–3 and zinc4 compounds in the presence palladium or nickel complexes reported for synthesis biaryls. Davidson Triggs5 previously that arylboronic acids react sodium palladate give corresponding biaryls good yields. synthetic utility dimerization reaction is,...
PURPOSE Camptothecin-11 (CPT-11) is a new semisynthetic derivative of CPT, and has been shown to inhibit DNA topoisomerase I have strong antitumor activity with low toxicity in murine tumors. To evaluate the effectiveness CPT-11 patients non-small-cell lung cancer (NSCLC), phase II study was conducted between April 1989 February 1990. PATIENTS AND METHODS Seventy-three were entered onto study. All had no previous therapy measurable disease. Their median age 67 years (range, 34 75 years)....
Survivin is a recently described inhibitor of apoptosis. Because suppression apoptosis important for carcinogenesis and tumor growth, we investigated the expression function survivin in human hepatocellular carcinomas (HCCs). We have shown that 4 HCC cell lines 7 out 8 tissues expressed messenger RNA (mRNA), whereas mRNA was not detected normal liver nontumor areas these using reverse transcription polymerase chain reaction. primarily nucleus by immunofluorescence staining cells. In...
Super-hydrophilic polymer brushes were prepared by surface-initiated atom transfer radical polymerization of 2-methacryloyloxyethyl phosphorylcholine (MPC) on initiator-immobilized silicon wafers. The graft density was estimated to be ca. 0.22 chains nm−2 based the linear relationship between Mn and layer thickness. contact angle against water very low, air bubbles in hardly attached onto brush surface, indicating a super-hydrophilic surface. Neutron reflectivity measurements poly(MPC)...
Three molecular forms of prothoracicotropic hormone were isolated from the head adult silkworm, Bombyx mori, and amino acid sequence 19 residues in terminus these hormones was determined. These exhibit significant homology with insulin insulin-like growth factors.
We have determined the complete amino acid sequence of 4K-PTTH-II, one three forms M r 4400 prothoracicotropic hormone silkworm Bombyx mori , active to brainless pupae Samia cynthia ricini . Like vertebrate insulin, it consists two nonidentical peptide chains (A and B chains). The A chain 20 residues. is a mixture four microheterogeneous peptides, which consist 28 residues, other two, 26 4K-PTTH-II has considerable homology (40%) with human resembles porcine relaxin both in carboxyl-terminal...
TNF-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis in various transformed cell lines but not almost-normal tissues. It is regulated by 2 death receptors, TRAIL receptor 1 (TRAIL-R1) and TRAIL-R2, decoy TRAIL-R3 TRAIL-R4. We investigated the expression of TRAIL-R– TRAIL-induced human hepatocellular carcinomas (HCCs). TRAIL-R1, -R2, -R4 were expressed 6 HCC examined, was only lines. In addition, immunohistochemical results revealed a high prevalent TRAIL-R1 -R2 Despite...
AbstractLeptin stimulates fatty acid oxidation in skeletal muscle through the activation of AMP-activated protein kinase (AMPK) and induction gene expression, such as that for peroxisome proliferator-activated receptor α (PPARα). We now show leptin PPARα expression C2C12 cell line AMPK containing α2 subunit (α2AMPK) changes subcellular localization this enzyme. Activated α2AMPK β1 was shown to be retained cytoplasm, where it phosphorylated acetyl coenzyme A carboxylase thereby stimulated...
Intra- and interspecific variability, being at the very core of alpha taxonomy, has been a long-standing topic debate among tardigrade taxonomists. Early studies tended to assume that tardigrades exhibit wide intraspecific variation. However, with more careful morphological studies, especially those incorporating molecular tools allow for an independent verification species identifications based on phenotypic traits, we now recognise ranges variability are narrower, differences between may...
We identified a novel human AMP-activated protein kinase (AMPK) family member, designated ARK5, encoding 661 amino acids with an estimated molecular mass of 74 kDa. The putative acid sequence reveals 47, 45.8, 42.4, and 55% homology to AMPK-alpha1, AMPK-alpha2, MELK, SNARK, respectively, suggesting that it is new member the AMPK family. It has Akt phosphorylation motif at 595-600, Ser(600) was found be phosphorylated by active resulting in activation activity toward SAMS peptide, consensus...
AMP-activated protein kinases (AMPKs) are a class of serine/threonine that activated by an increase in intracellular AMP concentration.They sensitive indicator cellular energy status and have been found to promote tumor cell survival during nutrient starvation.We recently identified novel AMPK catalytic subunit family member, ARK5, whose activation is directly regulated Akt, which, turn, has reported be key player malignancy.In this study, we attempted determine whether ARK5 involved...
OBJECTIVE The medial hypothalamus mediates leptin-induced glucose uptake in peripheral tissues, and brain melanocortin receptors (MCRs) mediate certain central effects of leptin. However, the contributions leptin receptor MCRs individual hypothalamic nuclei to regulation have remained unclear. We examined an injection MCR agonist MT-II into on tissues. RESEARCH DESIGN AND METHODS Leptin or was injected ventromedial (VMH), dorsomedial (DMH), arcuate nucleus (ARC), paraventricular (PVH)...
Time delay in bilateral control system seriously deteriorates performance and stability. Acceleration-based (ABC) is hybrid of position force the acceleration dimension based on a disturbance observer. It can be divided into two modal spaces: common differential spaces. The sum master slave controlled to zero space realize law action-reaction. difference for tracking. This paper analyzes stability each under time delay. Based analysis, this proposes novel "frequency-domain damping design"...
Death receptor Fas transduces cell death signaling upon stimulation by ligand, and this is mediated caspase. Recently, we reported that the cycle regulator p21 interacts with procaspase 3 to resist Fas-mediated death. In present study, molecular characterization functional region of 3-p21 complex was further investigated. We observed expression in mitochondrial fraction HepG2 cells detected only presence actinomycin D. However, mitochondrial-DNA-lacking (MDLH) showed effect even absence Both...
The Akt/PI-3 kinase pathway is a system essential for cell survival. In the current study, we showed that hepatocyte growth factor (HGF) activates to suppress Fas-mediated death in human hepatocellular carcinoma (HCC; 3 lines; SK-Hep1, HLE, and Chang Liver lines), hepatoblastoma (1 line; HepG2), embryonic WRL). Five tested lines resistance by pretreatment of HGF. This HGF-induced survival was suppressed wortmannin (Akt/PI-3 inhibitor), suggesting an involvement Akt. When cells were...
β,β-Difluorinated amino acid derivatives were synthesized via Mg(0)-promoted defluorination of α-trifluoromethyl iminoester. Bromination the difluoroenamine afforded bromodifluoromethyl iminoester in good yield. Pd-catalyzed asymmetric hydrogenation and subsequent transformations provided optically active β,β-difluoroglutamic β,β-difluoroproline derivatives.
The peptide pheromone, cCF10, which induces aggregation and high frequency plasmid transfer in Streptococcus faecalis cells carrying the tetracycline resistance plasmid, pCF10, was isolated its structure determined. molecular weight of cCF10 is 789, amino acid sequence H-Leu-Val-Thr-Leu-Val-Phe-Val-OH. Pheromone activity, as determined by a clumping induction assay, detectable at concentration 2.5 x 10(-11) M. A same that produced S. synthesized liquid-phase method. synthetic pheromone...
Bombyxin, previously referred to as 4K-prothoracicotropic hormone, is a brain peptide of the silkmoth Bombyx mori, amino acid sequence which shows considerable homology with vertebrate insulin family peptides. Two independent clones have been isolated from larval cDNA library by using synthetic oligonucleotide probe, one complete coding region for preprobombyxin (lambda Bb360) and other covering region, possibly bombyxin, only partially Bb204). lambda Bb360 encodes in order...