A5102020698- Liver Disease Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Renin-Angiotensin System Studies
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Brain Metastases and Treatment
- Neuroendocrine Tumor Research Advances
- Receptor Mechanisms and Signaling
- Hepatitis B Virus Studies
- Hormonal Regulation and Hypertension
- Lung Cancer Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Eicosanoids and Hypertension Pharmacology
- Gastrointestinal disorders and treatments
- Respiratory and Cough-Related Research
- Liver Diseases and Immunity
- Dialysis and Renal Disease Management
- CNS Lymphoma Diagnosis and Treatment
- Asthma and respiratory diseases
- Metabolism and Genetic Disorders
- Lung Cancer Research Studies
- Lymphoma Diagnosis and Treatment
- IgG4-Related and Inflammatory Diseases
- Lung Cancer Treatments and Mutations
Toyohashi Heart Center
2021-2025
National Hospital Organization
2025
Kyoto University
2024
Kansai Medical University
2024
Anjo Kosei Hospital
2020-2022
Yokohama Municipal Citizen's Hospital
2020-2022
Tokyo University of Science
2022
Centre Hospitalier Universitaire de Saint-Pierre
2021
Istanbul University
2021
Cliniques Universitaires Saint-Luc
2021
Survivin is a recently described inhibitor of apoptosis. Because suppression apoptosis important for carcinogenesis and tumor growth, we investigated the expression function survivin in human hepatocellular carcinomas (HCCs). We have shown that 4 HCC cell lines 7 out 8 tissues expressed messenger RNA (mRNA), whereas mRNA was not detected normal liver nontumor areas these using reverse transcription polymerase chain reaction. primarily nucleus by immunofluorescence staining cells. In...
Background and Purpose —Angiotensin II, through stimulation of AT 1 receptors, not only controls blood pressure but also modulates cerebrovascular flow. We sought to determine whether selective antagonists could be therapeutically advantageous in brain ischemia during chronic hypertension. Methods —We pretreated spontaneously hypertensive rats (SHR) normotensive Wistar-Kyoto with the antagonist candesartan (CV-11974), 0.5 mg/kg per day, for 3 14 days, via subcutaneously implanted osmotic...
Pretreatment with angiotensin II AT(1) receptor antagonists protects against cerebral ischemia. We studied whether modulation of blood flow (CBF) and morphometric changes in brain arteries participated this protective mechanism.We pretreated adult spontaneously hypertensive rats equally antihypertensive doses candesartan (0.1 or 0.3 mg/kg per day), nicardipine captopril (3.0 day) for 3 28 days via subcutaneous osmotic minipumps followed by permanent left middle artery (MCA) occlusion distal...
Angiotensin II, which stimulates AT(1) receptors, is a brain and peripheral stress hormone. We pretreated rats with the receptor antagonist candesartan for 13 d via sc-implanted osmotic minipumps, followed by 24-h isolation in individual metabolic cages. measured angiotensin II receptor-type binding mRNAs tyrosine hydroxylase mRNA quantitative autoradiography situ hybridization, catecholamines HPLC, hormones RIA. Isolation increased hypothalamic paraventricular nucleus as well anterior...
We retrospectively investigated the efficacy and feasibility of concurrent chemoradiotherapy for patients with severe dysphagia caused by oesophageal squamous cell carcinoma. Concurrent was performed in 57 T3 or T4 disease containing M1 lymph node (LYM) disease. Chemotherapy consisted protracted infusion 5-fluorouracil (5-FU) 400 mg m(-2) 24 h(-1) on days 1-5 8-12, combined 2-h cisplatin (CDDP) 40 1 8. Radiation treatment at a dose 30 Gy 15 fractions mediastinum administered concomitantly...
124 Background: Phase III trials (ML18147, VELOUR, and RAISE trials) of second-line combination therapy with molecular-targeted agents after first-line treatment bevacizumab (BEV) for metastatic colorectal cancer (mCRC) demonstrated significant improvements in overall survival (OS). In the trial (irinotecan (IRI) dose: 180 mg/m²), relative dose intensity (RDI) IRI was lower (63.8%) incidence rates adverse events leading to discontinuation cytotoxic higher (48.6%) Japanese population compared...
Positron emission tomography (PET) is important in the noninvasive diagnostic imaging of gliomas. There are many PET studies on glioma diagnosis based 2007 WHO classification; however, there no using new classification (the 2016 classification). Here, authors investigated relationship between uptake 11C-methionine (MET), 11C-choline (CHO), and 18F-fluorodeoxyglucose (FDG) isocitrate dehydrogenase (IDH) status (wild-type [IDH-wt] or mutant [IDH-mut]) astrocytic oligodendroglial tumors...
High-sensitivity C-reactive protein (hs-CRP) is a marker for low-grade inflammation, as well atherosclerosis, obesity, hyperglycemia and hypertension. Because the factor showing strongest association with inflammation currently unknown, we investigated associations between hs-CRP clinical biochemical characteristics in Japanese subjects mild obesity or impaired glucose tolerance.Subjects aged <65 years old, attending Seirei Medical Examination Center, underwent complete physical laboratory...
The thyroid hormone receptor (TR) and liver X (LXR)-α are members of the nuclear family ligand-dependent transcription factors. Among promoter target genes, TR LXR recognize T3 response element (LXRE), respectively. Because elements LXREs have similar configurations, referred to as direct repeat 4, we investigated possibility cross-talk between two signal transduction pathways. We found that TRβ1, a major isoform in liver, binds transactivates derived from mouse mammary tumor virus...
Rice cake is a traditional but very popular food in Asia including Japan and has never been known as cause of ileus. now becoming widespread the United States European countries along with other Japanese foods. We may encounter rice ileus all over world. This study was aimed at characterizing ileus.We consecutively encountered 14 patients from April 2003 to October 2010 our hospital. All characteristics cases were reviewed analyzed.All had ingested by swallowing without chewing. It most...
This research paper presents clinical outcomes of hypofractionated high-dose irradiation by intensity-modulated radiation therapy (Hypo-IMRT) with (11)C-methionine positron emission tomography (MET-PET) data for the treatment glioblastoma multiforme (GBM). A total 45 patients GBM were treated Hypo-IMRT after surgery. Gross tumor volume (GTV) was defined as area enhanced lesion on MRI, including MET-PET avid region; target (CTV) 5 mm margin surrounding GTV; planning (PTV) 15 CTV, moderate...
Age-associated differences in the effect of repetitive vaccination, particularly on memory T-cell and B-cell responses, remain unclear. While older adults (aged ≥65 years) exhibited enhanced IgG responses following COVID-19 mRNA booster they produced fewer spike-specific circulating follicular helper T cells-1 than younger adults. Similarly, cytotoxic CD8
Angiotensin II (Ang II) regulates cerebral blood flow by stimulating vasoconstriction via AT 1 receptors. In adult spontaneously hypertensive rats (SHR), the cerebrovascular autoregulatory curve is shifted to right, in direction of higher pressures, an indication excessive vasoconstriction. A restricted capacity dilate vessels may be responsible for enhanced vulnerability ischaemia during hypertension. We found that chronic treatment with -receptor antagonist, candesartan, (0.5 mg/kg/day 14...
<h3>To the Editor. —</h3> Various metabolites of proteins, vitamins, and drugs are excreted by kidney or intestines. Vitamin B<sub>2</sub>and its usually former vitamin E latter route. Patients receiving maintenance hemodialysis anuric oliguric, B<sub>2</sub>is automatically removed hemodialysis. Our previous investigation showed that dialysis rate total B<sub>2</sub>in vivo using Kiil dialyzer was 22.1 ± 9.2 ml/min (mean SD, n = 6), about one quarter urea creatinine. Serum creatinine blood...
Diffusion tensor imaging (DTI) has recently evolved as valuable technique to investigate diffuse axonal injury (DAI). This study examined whether fractional anisotropy (FA) images analyzed by statistical parametric mapping (FA-SPM images) are superior T2*-weighted gradient recalled echo (T2*GRE) or fluid-attenuated inversion recovery (FLAIR) for detecting minute lesions in traumatic brain (TBI) patients. DTI was performed 25 patients with cognitive impairments the chronic stage after mild...