A5087844371- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Colorectal Cancer Surgical Treatments
- Pediatric health and respiratory diseases
- Colorectal Cancer Screening and Detection
- Neutropenia and Cancer Infections
- Radiation Dose and Imaging
- Bacterial Identification and Susceptibility Testing
- Vitamin C and Antioxidants Research
- Medicinal plant effects and applications
- Mycobacterium research and diagnosis
- Protease and Inhibitor Mechanisms
- Neuroscience and Neuropharmacology Research
- Antibiotic Resistance in Bacteria
- Gastric Cancer Management and Outcomes
- Alcoholism and Thiamine Deficiency
- Pharmacy and Medical Practices
- Veterinary Equine Medical Research
- Colorectal Cancer Treatments and Studies
- Antibiotic Use and Resistance
- Tracheal and airway disorders
- Retinoids in leukemia and cellular processes
- Vascular Anomalies and Treatments
- Cerebrovascular and genetic disorders
- Biochemical Acid Research Studies
Fukuyama City Hospital
2014-2025
Kitasato University
2012-2024
Kyoto Prefectural University of Medicine
2013-2019
keiyu Hospital
2018-2019
Nippon Medical School Hospital
2010-2018
Menard (Poland)
2018
Asahi General Hospital
2016
Chubu University
2011-2013
Akita University
1998-2011
Teikyo University
2009
The combination of carbenicillin plus cephalothin (carb-ceph) was compared to the kanamycin (carb-kan) as therapy during 179 episodes presumed infection in 113 cancer patients with neutropenia. overall response rate similar for both treatment groups (48% vs. 49%). Among identified infection, 30 50 (60%) responded carb-ceph and 28 48 (58%) carb-kan. In persistent severe neutropenia, better carb-kan than (45% 15%), although difference not statistically significant. Neither routinely effective...
Comprehensive understanding prognostic relevance of distinct tumor microenvironment (TME) remained elusive in colon cancer. In this study, we performed silico analysis the stromal components primary cancer, with a focus on markers cancer-associated fibroblasts (CAF) and tumor-associated endothelia (TAE), as well immunological infiltrates like myeloid cells (TAMC) cytotoxic T lymphocytes (CTL). The relevant CAF-associated genes (CAFG)(representing R index = 0.9 or beyond SPARC ) were selected...
Fibroblast migration, proliferation, extracellular matrix protein synthesis and degradation,all of which play important roles in inflammation, are them selves induced by various growth factors cytokines. Less is known about the interaction these substances on lung fibroblast function pulmonary fibrosis. The goal this study was to investigate effects PDGF alone combination with IL–1β TNF–α production human metalloproteinases, chemotactic response. assay for MMPs activity against FITC labeled...
A quantitative method for four theaflavins and two methylated theaflavin derivatives in black tea leaves was developed by solid-phase extraction a high-performance liquid chromatographic with photodiode array detection. The were extracted three times 40 vol 50% aqueous ethanol (mg dry powder/mL) containing 2% ascorbic acid. extracts diluted 4-fold distilled water. All directly applied to the C18 cartridge column without concentration. fraction of obtained 40% after rinsing water followed 15%...
Abstract Introduction The advantages of robotic‐assisted laparoscopic surgery (RALS) for rectal cancer remain controversial. This study clarified and compared the short‐term outcomes RALS with those conventional (CLS). Methods records 303 consecutive patients who underwent or CLS adenocarcinoma between November 2016 2021 were analyzed using propensity score‐matched analysis. After matching, 188 enrolled in our to compare outcomes, such as operative results, postoperative complications,...
The purpose of this study was to measure the effective dose during abdominal three-dimensional imaging obtained with an angiography unit a digital flat-panel system on phantom and determine dose-area product (DAP)-to–effective conversion factors. DAPs doses were evaluated for 163-cm-tall human-shaped phantoms estimated body weights 54, 64, 77 kg, 2.1, 3.2, 4.2 mSv, respectively. DAP-to–effective factors 0.28–0.29 mSv · Gy−1 cm−2. In conclusion, useful estimating angiographic imaging. © RSNA, 2009
<h3>BACKGROUND AND PURPOSE: </h3> Some recent studies on radiation lens injuries have indicated much lower dose thresholds than specified by the current protection guidelines. The purpose of this research was to measure during brain CT scans with multidetector row and assess methods for estimating dose. <h3>MATERIALS METHODS: With 8 types scanners, both axial helical were obtained head part a human-shaped phantom using normal clinical settings orbitomeatal line as baseline. We measured doses...
Kodamaea ohmeri is a relatively rare yeast isolated form clinical specimens, and it known to be causative fungus of severe invasive infectious diseases in immunocompromised hosts. Herein, we describe fungemia due K. patient with extended burn. The isolate was obtained from not only blood specimens but also skin lesions. We should aware risk for including case
Chronic cough is the only symptom of eosinophilic bronchitis (EB). There considerable overlap between EB and atopic cough. To investigate antitussive effects a histamine H1-recetor antagonist, epinastine hydrochloride (epinastine, CAS 80012-43-7, Alesion; 20 mg/day, once daily), scores, pulmonary function, capsaicin threshold, bronchial hyperresonsiveness (BHR) to methacholine (MCh) were evaluated before after 4-week treatment with in patients EB. In group, scores decreased significantly...
Fibroblast migration, proliferation, extracellular matrix protein synthesis and degradation are the key events in various biological pathological processes pulmonary fibrosis. In addition, biopsy specimens from lungs of patients with fibrosis show increased numbers mast cells which have metachromatic granules containing heparin, histamine proteases. Little is known about how these products influence present study, we investigated effect heparin related glycosaminoglycans on PDGF-induced lung...
Temporohyoid osteoarthropathy (THO) is characterized by progressive osseous proliferation of the stylohyoid and petrous temporal bones. Generally, diagnosis confirmed guttural pouch endoscopy skull radiography. In present case, computed tomography (CT) magnetic resonance imaging (MRI) were performed in a 6-month-old Thoroughbred foal showing signs head tilt unilateral ear droop, consistent with presence vestibular disease facial paralysis. CT revealed bony fusion right temporohyoid joint,...
Elevated expression of transforming growth factor (TGF)-beta1 has been reported in hereditary cerebral small-vessel (HCSV) disease. The aim this study was to clarify whether TGF-beta1 is a risk for intracranial deep white matter lesions (DWLs) and their progression general elderly population.The subjects included 81 participants (Groups DWL, DWLP, C) who had voluntarily undergone health examination brain magnetic resonance imaging (MRI) 2003 2008 43 age-matched patients with previous...
Abstract The benefits of robot-assisted laparoscopic surgery (RALS) for rectal cancer remain controversial. Only a few studies have evaluated the safety and feasibility RALS following neoadjuvant chemoradiotherapy (NCRT). This study aimed to compare short-term outcomes versus conventional (CLS) after NCRT cancer. Propensity score matching 111 consecutive patients who underwent or CLS adenocarcinoma between February 2014 2022 was performed. Among them, 60 matched were enrolled their compared....
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a major hereditary small vessel disease caused by mutations in NOTCH3.The variations progression severity among patients suggest that the CADASIL phenotype modified some genetic environmental factors.Recent studies have shown potential roles of gut microbiota human diseases.We hypothesized modifies phenotype.We performed microbial meta 16S rRNA analysis fecal samples from 15 16...
Intracellular adhesion molecule-1 (ICAM-1)-mediated cell-cell is thought to play an important role at sites of inflammation. Recent evidence suggests that ICAM-1 surface expression on alveolar macrophages increased in pulmonary sarcoidosis and inflammatory granuloma formation characterized by the aggregation macrophages. The present study shows significantly elevated from patients with response tumor necrosis factor-alpha (TNF-alpha) interferon-gamma (INF-gamma) compared healthy controls....
Heparanase activity is correlated with the metastatic potential of several cancer cells and a key enzyme in breakdown tissue barriers. It also involved regulation growth factor cytokine activity. However, little known about factors that induce heparanase cells. We investigated effect three factors, plateletderived (PDGF), hepatocyte (HGF) basic fibroblast (bFGF), on mRNA induction lung vitro . In addition, we examined erythromycin (EM) clarithromycin (CAM), which are 14‐membered ring...
In order to clarify the mechanism of antitussive effects azelastine hydrochloride (azelastine, CAS 790307-93-0), cough responses inhaled capsaicin and substance P (SP) were evaluated before after administration in conscious guinea pigs. The concentrations SP also measured by radioimmunoassay anesthetized Capsaicin caused coughing pigs a dose-dependent fashion. After treatment with azelastine, capsaicin-induced decreased significantly, dose-response curve was shifted higher concentration...
Whether rectal cancer surgery by robotic-assisted laparoscopic provides beneficial advantages remains controversial. Although favorable outcomes in terms of the safety and technical feasibility have been demonstrated for cancer, long-term oncological only examined a few studies. This retrospective study subjects who underwent evaluated short- consecutive patients.Between November 2016 January 2020, we analyzed records 62 patients adenocarcinoma without distant metastasis to evaluate...
CD44 and CD133 are stem cell markers in colorectal cancer (CRC). has distinctive isoforms with different oncological properties like total (CD44T) variant (CD44V). Clinical significance of such remains elusive.Sixty colon were examined for CD44T/CD44V at mRNA level a quantitative PCR, clarified their association clinicopathological factors.(1) Both CD44T CD44V showed higher expression primary tumors than non-cancerous mucosas (p<0.0001), while was expressed even mucosa rather decreased the...