A5061941577- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Gastrointestinal Tumor Research and Treatment
- Esophageal and GI Pathology
- Metastasis and carcinoma case studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatitis C virus research
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Colorectal Cancer Surgical Treatments
- Cancer-related gene regulation
- RNA modifications and cancer
- Gastroesophageal reflux and treatments
- Bone health and treatments
- Helicobacter pylori-related gastroenterology studies
- Colorectal Cancer Treatments and Studies
- Colorectal and Anal Carcinomas
- Multiple and Secondary Primary Cancers
- Viral gastroenteritis research and epidemiology
- Lung Cancer Treatments and Mutations
- Pancreatic and Hepatic Oncology Research
- Eosinophilic Esophagitis
- Genetic factors in colorectal cancer
- Gastrointestinal disorders and treatments
Tokyo Women's Medical University
2023-2025
Kitasato University
2014-2023
Tachikawa Hospital
2020
Shinshu University
2018
University of Yamanashi Hospital
1995-1999
Teijin (Japan)
1992-1998
Vanderbilt University
1998
Chiba University
1990-1995
Okayama University
1992
Sapporo Medical University
1988
The presence of the hepatitis B e antigen (HBeAg) in serum is known to be a marker high degree viral infectivity. However, fulminant may occur persons who are negative for HBeAg. A single point mutation has been reported produce stop codon precore region virus DNA and prevent formation protein required make To determine whether precore-mutant causally related severe liver injury, we analyzed entire strains isolated from patients with fatal cases uncomplicated B.Serum was obtained 9 (5 4...
Individuals with chronic hepatitis B virus (HBV) infection are generally divided into asymptomatic healthy carriers and patients liver disease. Several studies have suggested that the core antigen could be an immunological target of cytotoxic T lymphocytes (CTL). To investigate possible pressure site from CTL, entire region HBV DNA was sequenced in 30 subjects (10 20 disease). No significant changes nucleotide sequence deduced amino acid residue were noted 10 carriers. In contrast, a cluster...
Hepatitis C virus (HCV) RNA was detected in the sera of patients with non-A, non-B chronic liver disease by polymerase chain reaction (PCR). extracted from serum, reverse transcribed to cDNA, and amplified PCR. With this method, 30 10 healthy subjects were tested. HCV 13 16 (81%) anti-HCV-positive also 7 14 (50%) anti-HCV-negative patients, but none subjects. Specificity method confirmed direct sequencing cDNA segment. The nucleotide sequences (37 nucleotides) obtained 15 showed only 68-78%...
Infection with hepatitis B virus leads to a wide spectrum of liver injury, including self-limited acute hepatitis, fulminant and chronic progression cirrhosis or exacerbation failure, as well an asymptomatic carrier state. Several studies have suggested that the core antigen could be immunological target cytotoxic T lymphocytes. To investigate reason why extreme attack occurred in severe patients, entire precore region DNA was sequenced 24 subjects (5 fulminant, 10 fatal exacerbation, 9...
429 Background: Esophagogastric junction (EGJ) cancer is difficult to cure with surgery alone, necessitating adjuvant chemotherapy. However, administering aggressive chemotherapy after invasive difficult. Neoadjuvant chemotherapy, on the other hand, expected enhance compliance, increase rate of curative resection, and reduce recurrence. Methods: We conducted a single center Phase I/II study evaluate safety efficacy neoadjuvant using docetaxel, oxaliplatin, S-1 (DOS), followed by in patients...
To overcome the problems of limited-region specificity associated with conventional radioimmunoassay (RIA), we developed a sandwich enzyme immunoassay (EIA) for intact human osteocalcin (hOC). For this EIA used antibodies to N- and C-terminal regions hOC that were raised against an N-terminal 20-residue peptide 7-residue peptide, both synthetic. Immunoassay profiles tryptic digests serum from patients renal failure, fractionated by reversed-phase HPLC, facilitated direct demonstration region...
Abstract Introduction The advantages of robotic‐assisted laparoscopic surgery (RALS) for rectal cancer remain controversial. This study clarified and compared the short‐term outcomes RALS with those conventional (CLS). Methods records 303 consecutive patients who underwent or CLS adenocarcinoma between November 2016 2021 were analyzed using propensity score‐matched analysis. After matching, 188 enrolled in our to compare outcomes, such as operative results, postoperative complications,...
We previously demonstrated that the lymph node ratio (LNR) is a prognostic factor associated with EGFR expression, among first priority genes amplified or overexpressed in cancer. Here, we investigated associations between high LNR and second, third, fourth genes. performed mRNA expression microarray analysis of tumor tissue from patients stage III gastric cancer low LNRs. Candidate LNR-associated were further evaluated 39 The functional relevance these was cell lines. focused on five genes:...
We have demonstrated that CDO1 methylation is frequently found in various cancers, including esophageal squamous cell carcinoma (ESCC), but its clinical relevance has remained elusive. was investigated 169 ESCC patients who underwent esophagectomy between 1996 and 2007. assessed by Q-MSP (quantitative specific PCR), significance, relationship to prognosis, analyzed. (i) The median TaqMeth value of 9.4, ranging from 0 279.5. significantly different cStage I II/III (P = 0.02). (ii) On the...
Abstract Background The incidence of metachronous multiple gastric cancer (MMGC) after gastrectomy remains unclear. This study evaluated the incidences MMGC according to specific types, including pylorus-preserving (PPG), proximal (PG), and function-preserving (FPG), which was categorized as segmental local resection. Methods We conducted a questionnaire survey Japanese Society for Gastro-Surgical Pathophysiology members, who were asked report their institutional numbers radical cases...