A5025262622- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Cancer Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Dysphagia Assessment and Management
- Helicobacter pylori-related gastroenterology studies
- Enhanced Recovery After Surgery
- Intraperitoneal and Appendiceal Malignancies
- Colorectal and Anal Carcinomas
- Neuroendocrine Tumor Research Advances
- Gastroesophageal reflux and treatments
- Pancreatic and Hepatic Oncology Research
- Nutrition and Health in Aging
- Colorectal Cancer Surgical Treatments
- Clinical Nutrition and Gastroenterology
- Cancer Treatment and Pharmacology
- Bariatric Surgery and Outcomes
- Breast Cancer Treatment Studies
- Gastrointestinal disorders and treatments
- Pituitary Gland Disorders and Treatments
- Inflammatory Biomarkers in Disease Prognosis
Kanazawa Medical University
2016-2025
Kanazawa Medical University Hospital
2016-2024
Kanazawa Medical Center
2010-2021
Toyama City Hospital
2021
Yokohama Municipal Citizen's Hospital
2017
Shizuoka Cancer Center
2016
Kanazawa University
2000-2013
Fukushima Medical University
2013
Kagoshima University
2013
Kanazawa University Hospital
1993-2008
Complicated gastric lymphatic drainage potentially undermines the utility of sentinel node (SN) biopsy in patients with cancer. Encouraged by several favorable single-institution reports, we conducted a multicenter, single-arm, phase II study SN mapping that used standardized dual tracer endoscopic injection technique.Patients previously untreated cT1 or cT2 adenocarcinomas < 4 cm gross diameter were eligible for inclusion this study. was performed using technique. Following identified SNs,...
Abstract Background Nodal status in gastric carcinoma is related not only to prognosis but also the extent of nodal dissection. However, a method for accurate assessment during operation has been established. This study aimed map sentinel nodes and estimate clinical usefulness node biopsy. Methods Following laparotomy, vital dye (0·2 ml 2 per cent patent blue) was injected through gastroscope into submucosal layer at four sites around T1 carcinoma. The immediately appeared serosal surface...
Esophageal adenocarcinoma arises from Barrett's esophagus, which is induced by gastro-esophageal reflux. This refluxate often contains duodenal contents, whose backflow triggers gastric carcinoma, suggesting the hypothesis that refluxed contents cause esophageal carcinoma. study examines role of and reflux in absence exogenous carcinogens carcinogenesis. Wistar male rats, 120 all, each weighing approximately 250 g, were used. Three experimental procedures performed to produce...
Indocyanine green (ICG) fluorescence imaging represents a promising method for sentinel node (SN) biopsy in laparoscopic gastric surgery due to its signal stability. In the present study, suitability and optimal settings of ICG SN early cancer were determined. Patients with single primary superficial-type adenocarcinoma stomach, lesions <5 cm diameter, no evident nodal metastasis out indication endoscopic submucosal dissection enrolled. The day prior surgery, solution was endoscopically...
To determine whether the elimination of bile reflux in established esophagojejunostomy model Barrett's esophagus (BE) will reduce or eliminate risk developing esophageal adenocarcinoma.Reflux duodenal juice as well gastric acid plays an important role pathogenesis BE and adenocarcinoma. Duodenoesophageal (DER) per se induces these diseases without carcinogen. However, it is unclear antireflux surgery regression prevents adenocarcinoma.Two hundred F344 male rats underwent one following 3...
not been clarified.Then, we weighed DG against TG to determine pure influence of whether presence or absence remaining stomach (as the reservoir capacity) by employing same reconstruction route.Moreover, reinforced findings multivariable analysis including other clinical factors, and defined effect sizes each variable in unprecedented examination with large number cases using newly developed Postgastrectomy Syndrome Assessment Scale-45.
Sphingomyelin synthase 2 (SMS2) is the synthetic enzyme of sphingomyelin (SM), which regulates membrane fluidity and microdomain structure. SMS2 plays a role in LPS-induced lung injury inflammation; however, its inflammation-mediated tumorigenesis unclear. We investigated effect deficiency on dextran sodium sulfate (DSS)-induced murine colitis found inhibition DSS-induced inflammation SMS2-deficient (SMS2-/-) mice. DSS treatment induced significant increase ceramide levels, with decrease SM...
The advantages of indocyanine green (ICG) fluorescence cholangiography have been emphasized, but its disadvantages remain unclear. This study investigated the and this modality, particularly optimal timing administration ICG fluorescence. was a retrospective analysis prospectively collected patient data. Data were gathered from single institution. 69 patients scheduled for cholecystectomy included. We administered intravenous injections at three different times: preoperatively (5 mg/body...
Abstract Aim This study explores the evolving landscape of gastrectomy procedures in Japan, based on nationwide surveys conducted 2014 and 2021. It highlights changes surgical approaches, including a growing focus minimally invasive function‐preserving procedures, as well increasing consideration postoperative quality life (QOL). Methods Two questionnaire were 2021, targeting members Japanese Society for Gastro‐surgical Pathophysiology. The covered institutional characteristics, case...
We investigated the presence and distribution of sentinel non-sentinel node micrometastases using complete serial sectioning immunohistochemical staining (IHC), to inspect whether lymph spread nodes first.A total 35 patients, who underwent gastrectomy with a biopsy for gastric cancer, were enrolled in this study. Total 1028 patients having cancer without metastasis by permanent section hematoxylin eosin (H&E) selected. There 252 other 776 nodes. All sectioned serially stained alternately H&E...
to the postoperative QOL.As for individual symptoms, meal-related distress, dumping, abdominal pain, and esophageal reflux significantly affected QOL in that order, while influence of indigestion, diarrhea constipation was insignificant. CONCLUSIONSeveral clinical factors such as symptom severity (especially distress dumping), ability working necessity additional meals were main which patients' wellbeing after gastrectomy.
Segmental gastrectomy, mini‑distal gastrectomy and local resection of the stomach are function‑preserving curative gastrectomies (FPGs), which used to treat gastric cancer in specialized centers. These surgical options less invasive can alleviate postgastrectomy symptoms more than standard gastrectomy; however, their association with prognosis remains be fully elucidated. The present study aimed compare survival patients diagnosed as node‑negative by sentinel node biopsy (SNB) treated via...
The use of staging laparoscopy (SL) has become widespread in patients with advanced gastric cancer (GC). This study aimed to evaluate the predictive value neutrophil/lymphocyte ratio (NLR) for presence peritoneal metastasis during GC. retrospective analysis was performed 35 GC who underwent SL at Kanazawa Medical University Hospital between January 2009 and December 2017. Clinicopathological characteristics were examined multivariate analyses identify preoperative laboratory parameters that...
Abstract Background The incidence of metachronous multiple gastric cancer (MMGC) after gastrectomy remains unclear. This study evaluated the incidences MMGC according to specific types, including pylorus-preserving (PPG), proximal (PG), and function-preserving (FPG), which was categorized as segmental local resection. Methods We conducted a questionnaire survey Japanese Society for Gastro-Surgical Pathophysiology members, who were asked report their institutional numbers radical cases...
Peritoneal metastasis is a crucial factor for the prognosis in gastric cancer, but its diagnosis difficult before laparotomy. We report on utility of laparoscopy and indications detection peritoneal cancer.A total 39 patients with cancer underwent cytology investigation our department, between April 1992 2000. Laparoscopic (LP-P) was determined through macroscopic, pathological cytological diagnoses. All diagnostic imaging computed tomography (CT) ultrasound laparoscopy. Carcinoembryonic...
Comparison of effects six main gastrectomy procedures on patients’ quality life assessed by Postgastrectomy Syndrome Assessment Scale-45
This prospective multicenter non-randomized phase III study aims to evaluate the long-term outcome of sentinel node navigation surgery for early gastric cancer compared with conventional distal or total gastrectomy. Clinically diagnosed primary T1N0M0 patients a single lesion (≤40 mm) and without previous endoscopic treatment will be enrolled in this study. Sentinel nodes are identified by dye radioisotope tracers subjected intraoperative rapid pathology. For negative metastasis,...