A5013007335- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Atrial Fibrillation Management and Outcomes
- Gastrointestinal disorders and treatments
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- Biliary and Gastrointestinal Fistulas
- Cancer Diagnosis and Treatment
- Neurological disorders and treatments
- Abdominal vascular conditions and treatments
- Cardiac Structural Anomalies and Repair
- Esophageal and GI Pathology
- Pharmacogenetics and Drug Metabolism
- Sarcoma Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Renal cell carcinoma treatment
- Sarcoidosis and Beryllium Toxicity Research
National Cerebral and Cardiovascular Center
2017-2025
Kanazawa Medical University Hospital
2014-2025
Hirosaki University
2024
Murata (Japan)
2024
Medtronic (Japan)
2024
RELX Group (United States)
2024
RELX Group (United Kingdom)
2024
Kanazawa Medical University
2013-2022
Kumamoto University
2019-2020
Osaka City University
1999-2020
To elucidate the clinical and epidemiologic characteristics of optic neuritis in Japan.Multicenter cross-sectional, observational cohort study.A total 531 cases unilateral or bilateral noninfectious identified 33 institutions nationwide Japan.Serum samples from patients with were tested for anti-aquaporin-4 antibodies (AQP4-Abs) anti-myelin oligodendrocyte glycoprotein (MOG-Abs) using a cell-based assay correlated findings.Antibody positivity, radiologic characteristics, visual outcome.Among...
Epicardial unipolar mapping has not been thoroughly investigated in Brugada syndrome (BrS). To examine the characteristics of epicardial potentials BrS and investigate differences from overt cardiomyopathy. was performed 8 patients with 6 We J-wave amplitudes using recordings at delayed potential (DP) sites via bipolar recordings. The repolarization time (RT) around DP recording measured, maximum dispersion RT divided by distance defined as index (RTDI). baseline revealed significantly...
Thirty-four patients who had resection of cancer the pancreatic head were examined clinicopathologically to elucidate neural invasion extrapancreatic nerve plexus. Invasion retropancreatic tissue (rp+) was observed in 29 (85%) 34 patients, and plexus 21 (72%) with rp+. The incidence second region high (14 patients; 67%). degree tended increase as intrapancreatic became more severe lymph vessel marked. Based on these findings, en bloc involving fat is necessary surgical treatment head.
Indocyanine green (ICG) fluorescence imaging represents a promising method for sentinel node (SN) biopsy in laparoscopic gastric surgery due to its signal stability. In the present study, suitability and optimal settings of ICG SN early cancer were determined. Patients with single primary superficial-type adenocarcinoma stomach, lesions <5 cm diameter, no evident nodal metastasis out indication endoscopic submucosal dissection enrolled. The day prior surgery, solution was endoscopically...
Cytochromes P450 (CYPs) compose a superfamily of similar proteins involved in detoxification and elimination, as well activation wide variety compounds. Most CYP family members are localized the liver. In order to assess whether peripheral blood leukocytes (PBL) available surrogate for determination gene expression levels liver, we compared PBL with those liver tissues from patients hepatocellular carcinoma (HCC). We measured CYP1A1, 1A2, 1B1, 2A6, 2B6, 2C8, 2C9, 2C18, 2C19, 2D6, 2E1, 2F1,...
We examined the characteristics of an arachidonate 12-lipoxygenase in bovine tracheal epithelial cells relation to enzyme expressed leukocytes and platelets. Homogenous preparations intact or disrupted metabolized arachidonic acid predominantly (12S)-hydroxyeicosatetraenoic acid, subcellular fractionation by differential centrifugation demonstrated that activity was localized 100,000 x g supernatant (cytosol fraction). Analysis cytosolic enzymatic for pH dependence (maximum at 7.4-8.0),...
Background Aging is one of the major concerns and determinants indications for catheter ablation (CA) atrial fibrillation. This study aimed to assess safety CA in older patients with fibrillation undergoing CA. Methods Results The JROAD-DPC (Japanese Registry All Cardiac Vascular Diseases-Diagnosis Procedure Combination) a nationwide claims database using data from Japanese Diagnosis Combination/Per Diem Payment System. Among 6 632 484 records found between April 2012 March 2018 1058...
BackgroundCardiac resynchronization therapy (CRT) is effective for patients with heart failure a QRS duration (QRSd) > 150 milliseconds (ms). However, its beneficial effect appears to be limited those "mid-range" QRSd (120–149 ms). Recent studies have demonstrated that modifying the left ventricular end-diastolic volume (LVEDV), modified QRSd, improves prediction of clinical outcomes CRT.ObjectiveTo investigate impact in regarding efficacy CRT.MethodsWe conducted retrospective, multi-center,...
ABSTRACT Introduction An effective cardiac resynchronization therapy (CRT) algorithm classifies each left ventricular (LV) pace as or ineffective based on electrogram morphology. Loss of capture, latency, pseudo‐fusion during sinus rhythm, and rapid responses due to atrial fibrillation (AF) premature conductions (PVCs) are potential causes CRT pacing. However, little is known about the relationship between percentage pacing (%i‐CRT) response. Methods Results Among 136 consecutive recipients,...
Background: The effect of paced-QRS (p-QRS) duration on long-term outcomes is unclear, so we assessed the association between p-QRS and cardiac events.
Background Ventricular parasystole is strongly associated with ventricular fibrillation (VF) in patients non-ischaemic cardiomyopathy. However, the relationship between and cardiac sarcoidosis (CS) remains unclear. The purpose of this study was to examine prevalence CS. Methods This a retrospective observational 214 consecutive diagnosed CS (mean age: 69±12 years, 104 males, median follow-up period: 6.8 years (IQR: 3.2–10.7) our centre. We investigated who developed arrhythmia (VA) using...
Four cases are reported of the intraductal variant peripheral cholangiocarcinoma among surgical specimens from 32 hepatolithiasis.The cancers arose periphery stone-containing bile duct and spread chiefly along luminal surface.Microscopically, these tumors showed papillary proliferation therefore were diagnosed as spreading type cholangiocarcinoma.Mucosal dysplasia also was noticed in vicinity tumors.In six other cases, mucosal observed stone.Immunohistochemically, anti-CA 19-9 staining...
We investigated the gene expression of GAPDH, cytochrome P450 isoforms (CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2E1, CYP3A4, CYP3A5, and CYP3A7), UGT-dependent glucuronosyl transferase (UGT1A6 UGT1A9), ABC transporter (ABCB1) after exposure to 0.1, 0.5, 2.5% dimethyl sulfoxide (DMSO). GAPDH mRNA levels were less than 2 times higher or lower control at all DMSO concentrations. CYP1A1, CYP3A7, UGT1A9 0.1% 0.5% DMSO. UGT1A6, ABCB1 CYP2E1 CYP3A4 2.5-3.2 2.0-3.3 DMSO, respectively. 0.2-0.5 Exposure...