A5103113527- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Ion channel regulation and function
- Angiogenesis and VEGF in Cancer
- ECG Monitoring and Analysis
- Atrial Fibrillation Management and Outcomes
- Congenital heart defects research
- Hedgehog Signaling Pathway Studies
- Mesenchymal stem cell research
- Axon Guidance and Neuronal Signaling
- Silk-based biomaterials and applications
- Zebrafish Biomedical Research Applications
- Developmental Biology and Gene Regulation
- Atomic and Subatomic Physics Research
- Botulinum Toxin and Related Neurological Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Ischemia and Reperfusion
- Wound Healing and Treatments
- Pluripotent Stem Cells Research
- Viral Infections and Immunology Research
- Neurological disorders and treatments
- Non-Invasive Vital Sign Monitoring
- Cardiovascular Syncope and Autonomic Disorders
- Aortic aneurysm repair treatments
National Cerebral and Cardiovascular Center
2018-2025
Kumamoto University
2025
Okayama University
2000-2012
Tufts University
2003-2006
Kyoto Prefectural University of Medicine
2006
St. Elizabeth's Medical Center
2003-2006
Foundation for Biomedical Research and Innovation
2006
Curis (United States)
2004
St. Elizabeth Healthcare
2004
Tokai University
2003
Stromal cell-derived factor-1 (SDF-1) is a chemokine considered to play an important role in the trafficking of hematopoietic stem cells. Given close relationship between cells and endothelial progenitor (EPCs), we investigated effect SDF-1 on EPC-mediated vasculogenesis.Flow cytometric analysis demonstrated expression CXCR4, receptor SDF-1, by 66+/-3% EPCs after 7 days culture. In vitro modified Boyden chamber assay showed dose-dependent EPC migration toward (control versus 10 ng/mL 100...
Background— Sonic hedgehog (Shh) is a prototypical morphogen known to regulate epithelial-mesenchymal interaction during embryonic development. Recent observations indicate that exogenous administration of Shh can induce angiogenesis and may accelerate repair ischemic myocardium skeletal muscle. Because plays pivotal role in wound repair, we hypothesized activation the pathway promote favorable effect on microvascular remodeling cutaneous healing thereby closure. diabetes associated with...
We performed a series of investigations to test the hypothesis that combining angiogenic gene therapy and cytokine (CK)-induced endothelial progenitor cell mobilization would be superior either strategy alone for treatment chronic myocardial ischemia.A swine model ischemia murine acute infarction were used in this study. In both models, animals randomly assigned 1 4 groups: Combo group, intramyocardial vascular growth factor (VEGF)-2 transfer plus subcutaneous injection CKs; VEGF-2, VEGF-2...
The embryonic morphogen sonic hedgehog (SHh) has been shown to induce neovascularization of ischemic tissue but not play a role in regulating vascular nerve supply. Accordingly, we investigated the hypothesis that systemic injection SHh protein could improve blood flow and function diabetic neuropathy (DN).Twelve weeks after induction diabetes with streptozotocin, motor sensory conduction velocities (MCV SCV) sciatic nerves were significantly reduced rats. SHh-treated rats demonstrated...
Background: The effect of paced-QRS (p-QRS) duration on long-term outcomes is unclear, so we assessed the association between p-QRS and cardiac events.
ABSTRACT Introduction An effective cardiac resynchronization therapy (CRT) algorithm classifies each left ventricular (LV) pace as or ineffective based on electrogram morphology. Loss of capture, latency, pseudo‐fusion during sinus rhythm, and rapid responses due to atrial fibrillation (AF) premature conductions (PVCs) are potential causes CRT pacing. However, little is known about the relationship between percentage pacing (%i‐CRT) response. Methods Results Among 136 consecutive recipients,...
ABSTRACT Introduction The role of corticosteroids in the management ventricular tachyarrhythmia (VA) cardiac sarcoidosis (CS) remains controversial. This study assessed effect early steroid initiation on VA recurrence rates patients with CS and evaluated frequency before after therapy. Methods From a registry 137 arrhythmias, those more than 60 days follow‐up were included. Patients categorized into three groups: previous‐on‐steroid, using at time first ( n = 15); early‐steroid, within 21);...
Background: Brugada syndrome (BrS) is associated with mutations in the cardiac sodium channel gene, SCN5A. However, genetic studies of patients BrS arrhythmic events have been limited. We sought to compare various clinical, ECG, and electrophysiological parameters according SCN5A genotype a large cohort probands first event. Methods: Survey on Arrhythmic Events Syndrome survey 10 Western 4 Asian countries, gathering 678 Only were included, adjudicated. Patients without appropriate data...
Abstract Background Detecting asymptomatic and undiagnosed atrial fibrillation (AF) is increasingly important. Recently, we developed a wristwatch‐based pulse wave monitor (PWM; Seiko Epson, Japan) capable of long‐term recording, with an automatic diagnosis algorithm that uses frequency‐based analysis. The aim this study was to evaluate the validity continuous monitoring for detection AF. Methods During electrophysiological (EPS) in patients AF, simultaneous Holter electrocardiograms (ECG)...
We investigated the relationship between effects of ischemic preconditioning (IPC) and Ca(2+) (CPC) on reperfusion-induced arrhythmias. In control group (noPC), Langendorff-perfused rat hearts were subjected to 5-min zero-flow global ischemia (I) followed by 15-min reperfusion (I/R). groups (IPC), three cycles 3-min reperfusion. CPC group, exposed perfusion higher (2.3 mmol/l Ca(2+)) normal 1.3 Ca(2+), then I/R. Verapamil was administered in several IPC (VR+IPC). Ventricular arrhythmias upon...
Abstract Background The MADIT-ICD benefit group, derived from ventricular tachycardia (VT)/ventricular fibrillation (VF) scores and non-arrhythmic mortality (Table 1), facilitates the appropriate selection of candidates for implantable cardioverter-defibrillator (ICD) therapy. While 2021 European Society Cardiology Guidelines have discussed advantages considerations adding a defibrillator in patients undergoing cardiac resynchronization therapy (CRT), optimal CRT with or without remains...
Abstract Background Catheter ablation is an effective rhythm control therapy for atrial fibrillation (AF). Recent advancements in technology have improved the efficacy and safety of this procedure. Current European Society Cardiology Japanese Circulation guidelines recommend that catheter (CA) patients with paroxysmal AF (PAF) after failure drug classified as Class I, CA first-line categorized IIa. However, there are limited clinical studies directly comparing these groups. Objective This...
Although the MADIT-ICD benefit score (MBS) helps select suitable implantable cardioverter defibrillator (ICD) candidates, optimal indicators for cardiac resynchronization therapy (CRT) remain uncertain. Evaluating applicability of MBS in Japanese CRT patients is imperative.
A 72-year-old female underwent an electrophysiological study for a paroxysmal narrow irregular tachycardia refractory to beta-blockers and bepridil, which had been diagnosed along with atrial fibrillation (PAF) using wearable device (Figure 1A). few years prior, the patient undergone pulmonary vein isolation PAF slow pathway ablation typical atypical atrioventricular (AV) nodal reentrant (AVNRT). Her clinical examination echocardiographic findings were unremarkable, except presence of...
Background: Abdominal aortic aneurysm (AAA) is characterized by the destruction of tissue architecture due to chronic inflammation. Emerging clinical evidence showed effectiveness angiotensin-converting enzyme inhibitor (ACEI) on prognosis AAA more than angiotensin II receptor blockers (ARB). We investigated effects an ACEI, imidapril and ARB, losartan, activity matrix metalloproteinase (MMP)-2 -9 in human murine tissues. Methods: Five specimens were obtained as a whole abdominal (from...