Tsukasa Kamakura
A5031042124- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- ECG Monitoring and Analysis
- Ion channel regulation and function
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular Effects of Exercise
- Cardiomyopathy and Myosin Studies
- Neuroscience and Neural Engineering
- Neurological disorders and treatments
- Receptor Mechanisms and Signaling
- Cardiac Imaging and Diagnostics
- Pulmonary Hypertension Research and Treatments
- Pluripotent Stem Cells Research
- S100 Proteins and Annexins
- Pleural and Pulmonary Diseases
- Pericarditis and Cardiac Tamponade
- Obstructive Sleep Apnea Research
- Microbial Metabolism and Applications
- Cancer, Hypoxia, and Metabolism
- Analog and Mixed-Signal Circuit Design
- Cardiac Health and Mental Health
- Cardiac Arrest and Resuscitation
- Tissue Engineering and Regenerative Medicine
National Cerebral and Cardiovascular Center
2016-2025
RELX Group (United States)
2024
RELX Group (United Kingdom)
2024
Electrophysiology and Heart Modeling Institute
2015-2023
Centre Hospitalier Universitaire de Bordeaux
2020-2023
Hôpital Cardiologique du Haut-Lévêque
2020-2023
Université de Bordeaux
2020-2022
Inserm
2015-2020
Centre de Recherche Cardio-Thoracique de Bordeaux
2020
University of Rochester Medical Center
2019
Background: In the short- to mid-term, cardiomyocytes generated from human-induced pluripotent stem cells (hiPSC-CMs) have been reported be less mature than those of adult hearts. However, maturation process in a long-term culture remains unknown. Methods and Results: A hiPSC clone healthy control was differentiated into CMs through embryoid body (EB) formation. The ultrastructural characteristics gene expressions spontaneously contracting EBs were analyzed 1-year after cardiac...
Data on the age at first arrhythmic event (AE) in Brugada syndrome are from limited patient cohorts. The aim of this study is 2-fold: (1) to define AE a large cohort patients with syndrome, and (2) assess influence mode documentation, sex, ethnicity AE.A survey 23 centers 10 Western 4 Asian countries gathered data 678 (91.3% men) documented time aborted cardiac arrest (group A, n=426) or after prophylactic implantable cardioverter-defibrillator implantation B, n=252). vast majority (94.2%)...
Background: Vein of Marshall (VOM) ethanol infusion is a relatively new therapeutic option for atrial tachyarrhythmias. We aimed to evaluate the feasibility, pitfalls, and complications associated with this procedure in large cohort patients. Methods: Successful infusion, VOM-related lesion extent, serious were evaluated 713 consecutive patients treated VOM infusion. Results: While feasible 88.9% cases, failure mainly resulted from nonidentification (6.2%), noncannulation (1.5%), or wrong...
Risk stratification in patients with Brugada syndrome for primary prevention of sudden cardiac death is still an unsettled issue. A recent consensus statement suggested the indication implantable cardioverter defibrillator (ICD) depending on clinical risk factors present (spontaneous type 1 electrocardiogram (ECG) [Sp1], history syncope [syncope], and ventricular fibrillation during programmed electrical stimulation [PES+]). The ICD majority patients, however, remains unclear.A total 218...
Human induced pluripotent stem cells (hiPSCs) offer a unique opportunity for disease modeling. However, it is not invariably successful to recapitulate the phenotype because of immaturity hiPSC-derived cardiomyocytes (hiPSC-CMs). The purpose this study was establish and analyze iPSC-based model catecholaminergic polymorphic ventricular tachycardia (CPVT), which characterized by adrenergically mediated lethal arrhythmias, more precisely using electrical pacing that could promote development...
Background A combination of clinical and electrocardiographic risk factors is used for stratification in Brugada syndrome. In this study, we tested the hypothesis that incorporation latent variables between using nonnegative matrix factorization can improve compared with logistic regression. Methods Results This was a retrospective cohort study patients presented patterns 2000 2016 from Hong Kong, China. The primary outcome spontaneous ventricular tachycardia/ventricular fibrillation....
The long-term prognosis of cardiac ryanodine receptor (RyR2) positive catecholaminergic polymorphic ventricular tachycardia (CPVT) patients after initiation medical therapy has not been well investigated. This study aimed to assess the recurrence fatal event inRyR2-positive CPVT patients.Thirty-fourRyR2-positive with a history events were enrolled. All had treatment initiated first symptom or diagnosis. Exercise stress tests (ESTs) performed evaluate efficacy therapy. Even therapy, high-risk...
Background: The effect of paced-QRS (p-QRS) duration on long-term outcomes is unclear, so we assessed the association between p-QRS and cardiac events.
Abstract Introduction Systematic and quantitative descriptions of vein Marshall (VOM)‐induced tissue ablation are lacking. We sought to characterize the distribution low voltage observed in left atrium (LA) after VOM ethanol infusion. Methods Results The ethanol‐induced was evaluated by comparing high‐density maps performed before infusion 114 patients referred for atrial fibrillation ablation. two most frequently impacted segments were inferior portion ridge (82.5%) first half mitral...