Kenzaburo Nakajima

ORCID: 0000-0002-1279-6558
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About
Contact & Profiles
Research Areas
  • Cardiac Arrhythmias and Treatments
  • Cardiac pacing and defibrillation studies
  • Cardiac electrophysiology and arrhythmias
  • Atrial Fibrillation Management and Outcomes
  • Cardiac Structural Anomalies and Repair
  • Sarcoidosis and Beryllium Toxicity Research
  • Neurological disorders and treatments
  • Cardiomyopathy and Myosin Studies
  • ECG Monitoring and Analysis
  • Cardiovascular Syncope and Autonomic Disorders
  • Cardiovascular Effects of Exercise
  • Viral Infections and Immunology Research
  • Pulmonary Hypertension Research and Treatments
  • Ion channel regulation and function
  • Congenital Heart Disease Studies
  • Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Nuclear Structure and Function
  • Health Systems, Economic Evaluations, Quality of Life
  • Heart Failure Treatment and Management
  • Infective Endocarditis Diagnosis and Management
  • RNA Research and Splicing
  • Neuroscience and Neural Engineering
  • Muscle activation and electromyography studies
  • Cerebrovascular and Carotid Artery Diseases
  • Vascular anomalies and interventions

National Cerebral and Cardiovascular Center
2015-2025

RELX Group (United States)
2024

RELX Group (United Kingdom)
2024

Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2021-2022

Vita-Salute San Raffaele University
2021-2022

Kumamoto University
2018-2021

San Raffaele University of Rome
2021

Tokyo Medical University Hachioji Medical Center
2006

General Hospital of Drama
1995

Mutations in LMNA (lamin A/C), which encodes lamin A and C, typically cause age-dependent cardiac phenotypes, including dilated cardiomyopathy, conduction disturbance, atrial fibrillation, malignant ventricular arrhythmias. Although the type of mutations have been reported to be associated with susceptibility arrhythmias, gene-based risk stratification for complications remains unexplored.The multicenter cohort included 77 mutation carriers from 45 families; disorders were retrospectively...

10.1161/circgenetics.116.001603 article EN Circulation Cardiovascular Genetics 2017-12-01

Epicardial unipolar mapping has not been thoroughly investigated in Brugada syndrome (BrS). To examine the characteristics of epicardial potentials BrS and investigate differences from overt cardiomyopathy. was performed 8 patients with 6 We J-wave amplitudes using recordings at delayed potential (DP) sites via bipolar recordings. The repolarization time (RT) around DP recording measured, maximum dispersion RT divided by distance defined as index (RTDI). baseline revealed significantly...

10.1016/j.jacep.2024.05.012 article EN cc-by JACC. Clinical electrophysiology 2024-05-16

Diagnosis of cardiac sarcoidosis (CS) is sometimes difficult due to a low positive rate epithelioid granulomas by endomyocardial biopsy (EMB). Accordingly, Japanese guidelines can allow the CS diagnosis using clinical data alone without EMB results (clinical CS) since 2006. However, little known about prognosis and outcome CS.Purpose this study was analyze prognosis, outcomes, response corticosteroid large-scale cohort survey.Overall, 422 patients (mean age 60 ± 13 years, 68% female, median...

10.1016/j.jacasi.2021.09.005 article EN cc-by-nc-nd JACC Asia 2021-12-01

Background: Pulmonary vein isolation (PVI) is a cornerstone of catheter ablation in patients with paroxysmal atrial fibrillation, and balloon-based has been recently performed worldwide. The second-generation cryoballoon (CB2) proven to be highly effective achieving freedom from fibrillation. However, there are some debatable questions, including the ideal number freeze cycles. Methods: AD-Balloon study (Multicenter Study Validity Additional Freeze Cycles for Cryoballoon Ablation) was...

10.1161/circep.118.006989 article EN Circulation Arrhythmia and Electrophysiology 2019-01-01

Background Aging is one of the major concerns and determinants indications for catheter ablation (CA) atrial fibrillation. This study aimed to assess safety CA in older patients with fibrillation undergoing CA. Methods Results The JROAD-DPC (Japanese Registry All Cardiac Vascular Diseases-Diagnosis Procedure Combination) a nationwide claims database using data from Japanese Diagnosis Combination/Per Diem Payment System. Among 6 632 484 records found between April 2012 March 2018 1058...

10.1161/jaha.120.019701 article EN cc-by-nc-nd Journal of the American Heart Association 2021-05-27

Background Ventricular parasystole is strongly associated with ventricular fibrillation (VF) in patients non-ischaemic cardiomyopathy. However, the relationship between and cardiac sarcoidosis (CS) remains unclear. The purpose of this study was to examine prevalence CS. Methods This a retrospective observational 214 consecutive diagnosed CS (mean age: 69±12 years, 104 males, median follow-up period: 6.8 years (IQR: 3.2–10.7) our centre. We investigated who developed arrhythmia (VA) using...

10.1136/openhrt-2025-003196 article EN cc-by-nc-nd Open Heart 2025-01-01

Mutation in the lamin A/C gene (LMNA) is associated with several cardiac phenotypes, such as conduction disorders (CCD), atrial arrhythmia (AA), malignant ventricular (MVA) and left dysfunction (LVD), leading to sudden death (SCD) and/or end-stage heart failure. We investigated how these phenotypes are each other which of them most important for total mortality. Methods Results: A multicenter registry included 110 LMNA mutation carriers (age, 43±15 years, male: 62%) from 60 families. After...

10.1253/circj.cj-18-0339 article EN Circulation Journal 2018-08-03

The prognosis and later fatal arrhythmia in cardiac sarcoidosis (CS) with relatively preserved function were unclear.This study aimed to evaluate the arrhythmic events patients CS mildly impaired function.Data collected from a nationwide Japanese cohort survey conducted 57 hospitals (n = 420); 322 left ventricular ejection fraction (LVEF) >35% investigated.Ventricular tachycardia (VT) manifestation was present 50 (16%) absent 272 (84%), of whom 36 (72%) 46 (17%), respectively, had an...

10.1016/j.jacasi.2023.07.006 article EN cc-by-nc-nd JACC Asia 2023-09-05

Abstract Introduction Infection is one of the most important complications associated with cardiac implantable electronic device (CIED) therapy. The number reports comparing outcomes transvenous lead extraction (TLE), surgical extraction, and conservative treatment for CIED infections using a real‐world database limited. This study investigated association between strategies their outcomes. Methods We performed retrospective analysis 3605 patients admitted to 681 hospitals nationwide...

10.1111/pace.14789 article EN Pacing and Clinical Electrophysiology 2023-07-23
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