A5024412870- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Ion channel regulation and function
- ECG Monitoring and Analysis
- Cardiovascular Effects of Exercise
- Cardiomyopathy and Myosin Studies
- Cardiac Structural Anomalies and Repair
- Cardiovascular Syncope and Autonomic Disorders
- Neurological disorders and treatments
- Cardiovascular Function and Risk Factors
- Heart Rate Variability and Autonomic Control
- Cardiac Valve Diseases and Treatments
- Sarcoidosis and Beryllium Toxicity Research
- Viral Infections and Immunology Research
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Health Systems, Economic Evaluations, Quality of Life
- Advanced MRI Techniques and Applications
- Congenital Heart Disease Studies
- Receptor Mechanisms and Signaling
- Pulmonary Hypertension Research and Treatments
- Venous Thromboembolism Diagnosis and Management
- Infective Endocarditis Diagnosis and Management
National Cerebral and Cardiovascular Center
2016-2025
Tokyo Institute of Technology
2024
Nagase (Japan)
2024
Kyowa Chemical Industry (Japan)
2021
Mayo Clinic
2018-2019
University of Rochester Medical Center
2019
National Center for Global Health and Medicine
2017
Kindai University
2017
Kumamoto University
2013-2015
Bioengineering Center
2014
Phenotypic overlap of type 3 long QT syndrome (LQT3) with Brugada (BrS) is observed in some carriers mutations the Na channel SCN5A. While this important for patient management, clinical features, prevalence, and mechanisms underlying such have not been fully elucidated. To investigate basis overlap, we genotyped a cohort 44 LQT3 families multiple ethnicities from 7 referral centers found high prevalence E1784K mutation Of 41 carriers, 93% had LQT3, 22% BrS, 39% sinus node dysfunction....
The short-term clinical benefits of bone marrow mononuclear cell transplantation have been shown in patients with critical limb ischemia. purpose this study was to assess the long-term safety and efficacy thromboangiitis obliterans.Eleven limbs (3 rest pain 8 an ischemic ulcer) were treated by transplantation. followed up for events a mean 684+/-549 days (range 103 1466 days). At 4 weeks, improvement observed all 11 limbs, complete relief (36%). Pain scale (visual analog scale) score...
Substantial portion of early arrhythmia recurrence after catheter ablation for atrial fibrillation (AF) is considered to be due irritability in left atrium (LA) from the procedure. We sought evaluate whether 90-day use antiarrhythmic drug (AAD) following AF could reduce incidence and thereby promote reverse remodelling LA, leading improved long-term clinical outcomes. A total 2038 patients who had undergone radiofrequency paroxysmal, persistent, or long-lasting were randomly assigned either...
Most of recurrent atrial tachyarrhythmias after pulmonary vein isolation (PVI) for fibrillation (AF) are due to reconnection PVs. The aim the present study was evaluate whether elimination adenosine triphosphate (ATP)-induced dormant PV conduction by additional energy applications during first ablation procedure could reduce incidence tachyarrhythmias. We randomly assigned 2113 patients with paroxysmal, persistent, or long-lasting AF either ATP-guided PVI (1112 patients) conventional (1001...
It is unclear how the amplitude of bipolar electrogram relates to local conduction velocity (CV) in patients with atrial fibrillation (AF). For 50 AF (paroxysmal/persistent AF: 40/10 patients), contact voltage maps left atrium (LA) were constructed during sinus rhythm using EnSite version 6.0J a point-by-point recording fashion. Patients divided into Groups A (n = 16), B 19), and C 15) according level lowest amplitudes: <0.5, 0.5-0.75, 0.75-1.0 mV, respectively. Low-voltage zone (LVZ) was...
Risk stratification in patients with Brugada syndrome for primary prevention of sudden cardiac death is still an unsettled issue. A recent consensus statement suggested the indication implantable cardioverter defibrillator (ICD) depending on clinical risk factors present (spontaneous type 1 electrocardiogram (ECG) [Sp1], history syncope [syncope], and ventricular fibrillation during programmed electrical stimulation [PES+]). The ICD majority patients, however, remains unclear.A total 218...
Epicardial unipolar mapping has not been thoroughly investigated in Brugada syndrome (BrS). To examine the characteristics of epicardial potentials BrS and investigate differences from overt cardiomyopathy. was performed 8 patients with 6 We J-wave amplitudes using recordings at delayed potential (DP) sites via bipolar recordings. The repolarization time (RT) around DP recording measured, maximum dispersion RT divided by distance defined as index (RTDI). baseline revealed significantly...
AimsTo examine the impact of left atrial (LA) low-voltage zones (LVZs) on fibrillation (AF) recurrence after pulmonary vein antrum isolation (PVAI) without LA substrate modification.
<h3>Background</h3> Pregnancy is one of the biggest concerns for women with long QT syndrome (LQTS). <h3>Objectives</h3> This study investigated pregnancy-related arrhythmic risk and efficacy safety β-blocker therapy lethal ventricular arrhythmias in pregnant LQTS (LQT-P) their babies. <h3>Methods</h3> 136 pregnancies 76 LQT-P (29±5 years old; 22 LQT1, 36 LQT2, LQT3, 17 genotype-unknown) were enrolled. We retrospectively analysed clinical electrophysiological characteristics pregnancy...
Diagnosis of cardiac sarcoidosis (CS) is sometimes difficult due to a low positive rate epithelioid granulomas by endomyocardial biopsy (EMB). Accordingly, Japanese guidelines can allow the CS diagnosis using clinical data alone without EMB results (clinical CS) since 2006. However, little known about prognosis and outcome CS.Purpose this study was analyze prognosis, outcomes, response corticosteroid large-scale cohort survey.Overall, 422 patients (mean age 60 ± 13 years, 68% female, median...
The long-term prognosis of cardiac ryanodine receptor (RyR2) positive catecholaminergic polymorphic ventricular tachycardia (CPVT) patients after initiation medical therapy has not been well investigated. This study aimed to assess the recurrence fatal event inRyR2-positive CPVT patients.Thirty-fourRyR2-positive with a history events were enrolled. All had treatment initiated first symptom or diagnosis. Exercise stress tests (ESTs) performed evaluate efficacy therapy. Even therapy, high-risk...
Background Aging is one of the major concerns and determinants indications for catheter ablation (CA) atrial fibrillation. This study aimed to assess safety CA in older patients with fibrillation undergoing CA. Methods Results The JROAD-DPC (Japanese Registry All Cardiac Vascular Diseases-Diagnosis Procedure Combination) a nationwide claims database using data from Japanese Diagnosis Combination/Per Diem Payment System. Among 6 632 484 records found between April 2012 March 2018 1058...
Non-pulmonary vein (PV) foci are sometimes difficult to identify and eliminate. The EnSite array (EA) reveals the detailed beat-to-beat virtual activation. This study aimed characterize non-PV using EA.Sixty-five patients with paroxysmal atrial fibrillation (AF) were included. All had ectopy initiating AF and/or focal tachycardia analysed EA. underwent PV isolation (PVI) additional ablation of if present. EA revealed 59 in 48 (Group P) 19 17 N). In Group N, 12 (71%) also foci. frequently...
Landiolol effectively controls rapid heart rate in atrial fibrillation or flutter (AF/AFL) patients with left ventricular (LV) dysfunction. However, predicting landiolol Responders and Non-Responders who will experience adverse effects remains a challenge. The aim of this study was to clarify the potential applicability for AF/AFL refractory tachyarrhythmias (VTs) failure. A total 39 response ≥120 bpm 12 VTs were retrospectively enrolled. defined as whose suppressed less than 110 decreased...
Mexiletine is often used for medical therapy in LQT3 patients, however, the usefulness of mexiletine infusion test patients has not been reported. The aim this study was to evaluate detecting patients.We analyzed response 12-lead electrocardiogram parameters measured II or V5 i.v. (2 mg/kg) during sinus rhythm among 31 genotype-positive LQT (29 ± 18 years, 12 male). Change QTc interval after compared between (n=15, 24 21 9 male) and other (4 LQT1 LQT2; 34 14 3 Baseline RR, QT, were different...
Background: Pulmonary vein isolation (PVI) is a cornerstone of catheter ablation in patients with paroxysmal atrial fibrillation, and balloon-based has been recently performed worldwide. The second-generation cryoballoon (CB2) proven to be highly effective achieving freedom from fibrillation. However, there are some debatable questions, including the ideal number freeze cycles. Methods: AD-Balloon study (Multicenter Study Validity Additional Freeze Cycles for Cryoballoon Ablation) was...