A5101824730- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Radiation Dose and Imaging
- Health and Conflict Studies
- Carcinogens and Genotoxicity Assessment
- Insurance, Mortality, Demography, Risk Management
- Cardiac electrophysiology and arrhythmias
- Radiation Therapy and Dosimetry
- Pelvic and Acetabular Injuries
- Health, Environment, Cognitive Aging
- Pediatric Hepatobiliary Diseases and Treatments
- Pelvic floor disorders treatments
- Ovarian cancer diagnosis and treatment
- Global Health Care Issues
- Pesticide Residue Analysis and Safety
- Tea Polyphenols and Effects
- Body Composition Measurement Techniques
- Blood Pressure and Hypertension Studies
- Cancer Cells and Metastasis
- Cardiovascular Syncope and Autonomic Disorders
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cardiomyopathy and Myosin Studies
- Analytical chemistry methods development
- Brain Metastases and Treatment
Tenri Hospital
2020-2024
Hyogo Prefectural Amagasaki General Medical Center
2017-2024
Institute of Clinical and Experimental Medicine
2024
Radiation Effects Research Foundation
1982-2017
Kameda Medical Center
2008-2017
Kyushu University
2017
Fred Hutch Cancer Center
2010
Cancer Research Center
2010
University of Washington
2010
Teikyo University
2005
The present study, the ninth in a series that began 1961, extends time of surveillance 3 more years and covers period 1950-1985. It is based on recently revised doses, termed DS86. impact change from T65D to DS86 dose-response relationships for cancer mortality was described first this reports. Here, focus among 76,000 A-bomb survivors within LSS sample whom doses have been estimated, with emphasis biological issues associated radiation carcinogenesis. Briefly, following found: excess...
The association between green-yellow vegetables and fruit consumption risk of cancer death was investigated in a prospective study 38 540 men women who were atomic-bomb survivors Hiroshima Nagasaki, Japan. Study participants completed dietary questionnaire 1980–1981 followed-up for deaths until March 1998, during which time 3136 identified. Daily or almost daily associated with significant 12% reduction total mortality (RR=0.88; 95% CI, 0.80–0.96 intake compared once per week less)....
As part of the Ni-Hon-San Study, stroke incidence was compared in Japan and Hawaii cohorts. Stroke cases were classified two types, intracranial hemorrhage (ICH) thrombo-embolic (T-E). For each type about three times as great Hawaii. The ratio ICH/T-E 1/2.2 1/1.6 Hawaii, respectively. Blood pressure most important risk factor, followed by age for total both Proteinuria also a factor Conversely, an index animal food intake inversely related to stroke, significantly at suggestive level...
Based on the findings from Radiation Effects Research Foundation's studies of cohort Japanese atomic bomb survivors, it has been reported that total-body irradiation at 0.5–1.0 Gy could be responsible for increased rates mortality broad-based categories cardiovascular disease (CVD), i.e., stroke and heart disease. However, CVD consists various subtypes have potentially different radiation dose responses, as well subtype-specific risks not fully evaluated. Potential problems with changes in...
Deaths in the RERF Life Span Study (LSS) sample have been determined for years 1950-1985 and an analysis of cancer mortality with revised DS86 doses has described separately. In this report, we examine relationship to dose deaths from all diseases other than cancer. Although evidence is still limited, there seems be excess risk noncancer death at high (2 or 3 Gy over). Statistically, a pure quadratic linear-threshold model [the estimated threshold 1.4 (0.6-2.8 Gy)] found fit better simple...
The mortality and predictive factors of coronary heart disease among men Japanese ancestry in Japan Hawaii were compared on the basis 12 years follow-up data using comparable methods case ascertainment risk factor measurements. Among 1,687 (Japan) 7,536 (Hawaii) who free aged 45–69 at baseline examination In 1965–1968, 20 123 cases fatal identified. age-adjusted rate was 40% higher than Japan. difference not statistically significant, but consistent with earlier studies. More half this...
A study was made of the incidence cerebrovascular disease, chronological trends, and relationship between disease types risk factors in 16,491 citizens Hiroshima Nagasaki. The subjects underwent medical examination at least once 1958-74, were free initial examination. During 16-year period, 1.162 cases developed population, with diagnosis definite 621. By type, there 108 cerebral hemorrhage, 469 infarction, 33 subarachnoid 11 other unclassifiable types. As a factor elevation systolic...
A cohort of 16,711 residents Hiroshima and Nagasaki have participated in a program biennial clinical examination history taking that began 1958. During 1958-1974, total 621 confirmed cases cerebrovascular disease 218 coronary heart were incident. This study makes detailed the relationship between series blood pressure (BP) measurements cardiovascular risk. Two aspects are emphasized: quantitative risk both systolic (SBP) diastolic (DBP), predictive value BP levels some years past, given more...
Catheter ablation (CA) for atrial fibrillation (AF) in patients on hemodialysis (HD) is reported to have a high risk of late recurrence (LR). However, the relationship between early (ER) within 90-day blanking period after CA AF and LR HD remains unclear.
Abstract Introduction Some previous studies have reported that a first‐step ethanol infusion into the vein of Marshall (EIVOM) with touch‐up radiofrequency (RF) ablation can facilitate mitral isthmus (MI) block and improves outcomes in persistent atrial fibrillation (PeAF) patients. However, effect an initial RF adjunctive EIVOM has not been fully investigated. Methods This study enrolled 233 PeAF patients undergoing pulmonary isolation linear including MI, roof line, cavotricuspid ablation....
For 1950–80, 194 ovarian cancer cases were ascertained among the 70,030 females of Radiation Effects Research Foundation's Life-Span Study E-85 sample, and 106 autopsied with benign neoplasms all 3,046 autopsies performed in same sample. On basis microscopic review, 66% 84% tumor classified by histologic type. The age-adjusted incidence rates showed a statistically significant increase increased exposure dose, both entire exposed group (P<.01) microscopically reviewed subset (P<.01). This...
Japan has a shortage of tertiary medical care facilities for maternal and fetal medicine. Establishment efficient transport systems is needed pregnant women fetuses with severe complications. Maternal by helicopters expected to shorten transportation time advanced facilities, although its feasibility not yet been evaluated. The aim the present study was investigate status helicopter transport, conditions patients children transferred Kameda Medical Center (KMC).Between August 2005 July 2006,...
Frequency of marriage and birth as January 1973 was determined for persons exposed in utero to the atomic bombs 1945 controls. The rate lower heavily than non-exposed or lightly exposed. This difference is attributed partly lesser marriageability with mental retardation who are significantly more numerous among exposed, unmeasured variables, possibly including social discrimination against survivors bomb. No consistent relation observed between radiation exposure three reproductive indices:...
Abstract Background: The length of the interval between age at menarche and first birth is positively associated with breast cancer risk. We examined risk in atomic bomb survivors to investigate whether women exposed radiation had a higher radiogenic than same but outside this interval. Methods: Women (n = 30,113) were classified into three reproductive status time bombings (ATB) categories (premenarche, birth, or after birth). Poisson regression was used test primary hypothesis. Results:...
The aim of this study was to explore whether the pouch depth influenced radiofrequency (RF) duration and total delivered RF energy for cavotricuspid isthmus (CTI) ablation define cutoff value a deep pouch-specified strategy.This included 94 atrial fibrillation (AF) patients (56 males, age 68 ± 8.0 years). With intracardiac echocardiography, length were precisely measured. After standard AF ablation, all underwent CTI along lateral isthmus. If bidirectional block could not be achieved,...
Abstract Background Catheter ablation (CA) for atrial fibrillation (AF) is widely performed. However, the indication CA in patients with asymptomatic persistent AF still controversial. Methods Among 259 consecutive who were hospitalized initial of AF, a total 45 had retrospectively analyzed. Quality life (QOL) before and 1 year after was evaluated, changes cardiac function over 5 years also examined. QOL assessed using questionnaire (AFQLQ) developed by Japanese Heart Rhythm Society. In...
Abstract Background Short‐coupled variant of torsades de pointes (scTdP) is a disease characterized by TdP without QT prolongation, which initiated extremely short‐coupled ventricular extra‐systoles. Its genetic background remains rarely unveiled. Objective We aimed to identify variations in patients with scTdP and analyze the functional change mutant Na + channel identified patient. Methods results performed analysis for inherited arrhythmia‐related 45 genes using next‐generation sequencer...
The aim of the present work was to examine antioxidative effect EGCG after administering it perorally rats at a dose 150 mg/kg body weight. activity rat plasma, and plasma levels tissue distribution were determined. results showed that oral administration increased measured by preservation inner lipophilic antioxidant α-tocopherol during ex vivo oxidation hydrophilic radical initiator, 2nd, 5th 24th hours post dose. total in 0.82 0.5 μ M 2nd respectively as developed high-performance liquid...
(目的) 骨盤臓器脱に対する腹腔鏡下仙骨腟固定術（Laparoscopic sacrocolpopexy：LSC）について，当院における安全性および治療効果について検討した．
Abstract Background Advances in genetic testing has enabled identification of pathogenic variants different functional gene groups associated with non-dilated left ventricular cardiomyopathy (NDLCM)/dilated (DCM) and tachycardia (VT). However, there is limited data on the impact VT ablation outcome. Aim We aimed to assess likely pathogenic/pathogenic (LP/Pv) heart failure (HF) outcomes recurrence patients NDLCM/DCM after ablation. Methods Patients who underwent (next-generation sequencing)...
Lactoferrin, an iron-binding glycoprotein, has been found to have various biological functions in tissues. Although, many studies reported on salivary lactoferrin adults and children, little is known regarding fluid of neonates, especially under conditions chorioamnionitis (CAM) . Salivary concentrations neonates gradually increased as the days advanced when breast feeding started, levels elevated significantly. measured day delivery group delivered with were 3.4±0.5 μg/ml significantly...