A5064205368- Blood Pressure and Hypertension Studies
- Dementia and Cognitive Impairment Research
- Nutrition and Health in Aging
- Frailty in Older Adults
- Cardiovascular Health and Disease Prevention
- Nutritional Studies and Diet
- Renin-Angiotensin System Studies
- Hormonal Regulation and Hypertension
- Pharmaceutical Practices and Patient Outcomes
- Sleep and related disorders
- Health Systems, Economic Evaluations, Quality of Life
- Pharmacy and Medical Practices
- Obstructive Sleep Apnea Research
- Receptor Mechanisms and Signaling
- Cerebrovascular and Carotid Artery Diseases
- Neurological Disease Mechanisms and Treatments
- Adipose Tissue and Metabolism
- Geriatric Care and Nursing Homes
- Chronic Disease Management Strategies
- Intergenerational Family Dynamics and Caregiving
- Renal and Vascular Pathologies
- Muscle Physiology and Disorders
- Cerebrospinal fluid and hydrocephalus
- Alzheimer's disease research and treatments
- Body Composition Measurement Techniques
Osaka University
2016-2025
Osaka Health Science University
2022-2025
The University of Tokyo
2024
Berkeley Public Health Division
2023
University of California, Berkeley
2023
Osaka University of Human Sciences
2013-2023
Tokyo Metropolitan Institute of Gerontology
2023
Keio University
2023
Osaka University of Pharmaceutical Sciences
2022
Nanao hospital
2022
The conventional forelimb grip strength test is a widely used method to assess skeletal muscle function in rodents; this study, we modified improve its variability and consistency. had lower among trials days than the young C57BL6 mice, especially by improving variabilities male. was more sensitive detect difference motor between female male or old mice. When performed on mice during aging process, reduction of manifested 18 24 months age at group level individual level. similar detecting...
The aim of this study was to investigate the relationship between preoperative patient factors and postoperative half-year health care utilization reflecting recovery, common complications, comorbidities, significant concerns, identifying strong risk protective factors. This retrospective cohort utilized linear, quantile, ordinal regressions analyze Osaka National Health Insurance data from 26 606 elderly patients who underwent hip fracture surgery 2012 2018. key associated with multiple...
A rapid increase in the number of patients with dementia has emerged as a global health challenge. Accumulating evidence suggests that early diagnosis and timely intervention can delay cognitive decline. The is commonly performed using neuropsychological tests, such Mini-Mental State Examination (MMSE), administered by trained examiners. While these traditional tests are valid reliable, they neither simple nor sufficiently short routine screening tools for dementia. Here, we developed brief...
As part of the Ni-Hon-San Study, stroke incidence was compared in Japan and Hawaii cohorts. Stroke cases were classified two types, intracranial hemorrhage (ICH) thrombo-embolic (T-E). For each type about three times as great Hawaii. The ratio ICH/T-E 1/2.2 1/1.6 Hawaii, respectively. Blood pressure most important risk factor, followed by age for total both Proteinuria also a factor Conversely, an index animal food intake inversely related to stroke, significantly at suggestive level...
ACE type 2 (ACE2) functions as a negative regulator of the renin-angiotensin system by cleaving angiotensin II (AII) into 1-7 (A1-7). This study assessed role endogenous ACE2 in maintaining insulin sensitivity. Twelve-week-old male knockout (ACE2KO) mice had normal sensitivities when fed standard diet. AII infusion or high-fat, high-sucrose (HFHS) diet impaired glucose tolerance and sensitivity more severely ACE2KO than their wild-type (WT) littermates. The strain difference was not...
Aim: Mice that carry the Klotho mutation ( KL ‐ / ) manifest diverse age‐related disorders similar to those observed in humans. Thus, protein might function as an anti‐aging hormone mammals. Recently, we reported recombinant attenuated apoptosis and cellular senescence endothelial cells, but mechanism remained unclear. Here, designed vitro study test whether inhibitors of extracellular signal‐regulated kinase mitogen‐activated could affect regulation senescence. Methods: Cellular was...
Background. Chronic kidney disease (CKD) is caused by various risk factors of cardiovascular (CVD). The estimated glomerular filtration rate (eGFR) commonly used for the evaluation renal function in patients with CKD; however, it difficult to assess pathogenesis CKD and predict prognosis accurately using only eGFR. resistive index (RI) Doppler ultrasonography (RDU) thought be a good indicator vascular resistance atherosclerosis. In present study, we investigated whether RI could evaluate...
Arterial stiffness has been reported to correlate with cardiovascular disease (CVD). Brachial-ankle pulse wave velocity (baPWV) is easy measure and used as a marker evaluate arterial stiffness. The objective of the present study was determine cut-off value baPWV for predicting prognosis in prospective cohort study.Four hundred forty patients essential hypertension were analyzed 1 mean follow-up 6.3±0.1 years. Four from who did not have past history CVD and/or stroke 2 6.4±0.1 Stroke, CVD,...
The angiotensin II type 1 receptor (AT1) is a 7-transmembrane domain GPCR that when activated by its ligand II, generates signaling events promoting vascular dysfunction and the development of cardiovascular disease. Here, we show single-transmembrane oxidized LDL (oxLDL) (LOX-1) resides in proximity to AT1 on cell-surface membranes binding oxLDL LOX-1 can allosterically activate AT1-dependent events. oxLDL-induced human endothelial cells were abolished knockdown inhibited blockade (ARB)....
Background Growing evidence suggests that oral health may be an important factor associated with cognitive function in aged populations. However, many previous studies on this topic used insensitive indicators or did not include certain essential covariates. Thus, we examined the association between occlusal force and a large sample of older adults, controlling for dietary intake, vascular risk factors, inflammatory biomarkers, depression, genetic factors. Methods In cross-sectional study...
The associations among cognitive function, hypertension, and dyslipidemia in older adults are controversial. Therefore, we investigated the decline, dyslipidemia, their combination community-dwelling people 70s, 80s, 90s long-term observational Septuagenarians, Octogenarians, Nonagenarians, Investigation with Centenarians (SONIC) study. We administered Montreal Cognitive Assessment Japanese version (MoCA-J) by trained geriatricians psychologists, conducted blood testing pressure (BP)...
8CQ: Is comprehensive risk assessment using prediction models for the primary prevention of CVD helpful in reducing mortality?
Abstract Aim This study examines whether expressed emotion (EE) mediates the association between caregiver relationship closeness and behavioural psychological symptoms of dementia (BPSD). Methods We recruited 64 families with in Osaka collected data for 3 months. Caregiver–patient was assessed using Relationship Closeness Scale (RCS), BPSD measured Neuropsychiatric Inventory Questionnaire (NPI‐Q). EE evaluated Family Attitude (FAS). Results The results indicated significant correlations EE,...
Aim Among the many screening tools developed to detect frailty and disability in older adults, Clinical Frailty Scale (CFS) is a valid, reliable, easy‐to‐use tool has been translated into several languages. The aim of this study was demonstrate validity Japanese version CFS (CFS‐J). Methods necessary permissions were obtained from Rockwood colleagues. prepared by translation (English Japanese) verified back (Japanese English). Concurrent criterion assessed evaluating extent which relates...
To assess how visit-to-visit variability of SBP correlates with systemic atherosclerotic change and various prognoses.Visit-to-visit cardiovascular events. However, the mechanisms underlying impact on prognoses are poorly understood.A total 485 patients essential hypertension from Non-Invasive Atherosclerotic Evaluation in Hypertension (NOAH) study cohort were included. We analyzed correlation between multiple clinical parameters. Next, we prospectively examined frequency disease (CVD)...