A5036326762- Dental Health and Care Utilization
- Oral microbiology and periodontitis research
- Pediatric health and respiratory diseases
- Salivary Gland Disorders and Functions
- Dental Implant Techniques and Outcomes
- Dental Radiography and Imaging
- Temporomandibular Joint Disorders
- Gut microbiota and health
- Dental Erosion and Treatment
- Orthodontics and Dentofacial Orthopedics
- Dental materials and restorations
- Epigenetics and DNA Methylation
- HIV/AIDS oral health manifestations
- Metabolomics and Mass Spectrometry Studies
- Nutritional Studies and Diet
- dental development and anomalies
- Genetic Associations and Epidemiology
- Streptococcal Infections and Treatments
- Cleft Lip and Palate Research
- Stress Responses and Cortisol
- Oropharyngeal Anatomy and Pathologies
- Traditional Chinese Medicine Studies
- Health disparities and outcomes
- Organ Donation and Transplantation
- Dysphagia Assessment and Management
King's College London
2017-2024
St Thomas' Hospital
2021-2022
Guy's and St Thomas' NHS Foundation Trust
2021
Osaka University
2013-2020
Osaka Dental University
2014
Background Growing evidence suggests that oral health may be an important factor associated with cognitive function in aged populations. However, many previous studies on this topic used insensitive indicators or did not include certain essential covariates. Thus, we examined the association between occlusal force and a large sample of older adults, controlling for dietary intake, vascular risk factors, inflammatory biomarkers, depression, genetic factors. Methods In cross-sectional study...
Genetic and environmental risk factors contribute to periodontal disease, but the underlying susceptibility pathways are not fully understood. Epigenetic mechanisms malleable regulators of gene function that can change in response genetic stimuli, thereby providing a potential mechanism for mediating effects periodontitis. The aim this study is identify epigenetic changes across tissues associated with disease. Self-reported gingival bleeding history gum or tooth mobility, were used as...
Abstract The oral microbiota is emerging as an influential factor of host physiology and disease state. Factors influencing composition have not been well characterised. In particular, there a lack population-based studies. We undertook large hypothesis-free study the saliva microbiota, considering potential factors health (frailty; diet; periodontal disease), demographics (age; sex; BMI) sample processing (storage time), in (n = 679) TwinsUK cohort adult twins. Alpha beta diversity was...
Limited evidence describing how host genetic variants affect the composition of microbiota is currently available. The aim this study was to assess associations between a set candidate and microbial in both saliva gut TwinsUK registry. A total 1,746 participants were included provided stool samples. subset 1,018 also self-reported periodontal data, 396 those sample. Host DNA extracted from whole-blood samples processed for Infinium Global screening array, focusing on 37 selected...
Summary This study was conducted to quantify the genetic and environmental contributions oral disease function in twins. Participants were middle‐aged old twins, 116 monozygotic 16 dizygotic pairs whose mean age 66·1 ± 10·3 ( SD ) years. Number of teeth, percentage decayed, filled missing teeth periodontal status recorded as indicators disease. The widths upper lower dental arch served morphological figures. Furthermore, stimulated salivary flow rate, occlusal force masticatory performance...
Abstract Saliva, as a biofluid, is inexpensive and non-invasive to obtain, provides vital tool investigate oral health its interaction with systemic conditions. There growing interest in salivary biomarkers for diseases, notably cardiovascular disease. Whereas hundreds of genetic loci have been shown be involved the regulation blood metabolites, leading significant insights into pathogenesis complex human little known about impact host genetics on metabolites. Here we report first...
The aim of this study was to investigate the effect case severity on clinical outcomes when fabricating new complete dentures.Participants were separated into severe and moderate groups using index difficulty for edentulous patients developed by Japan Prosthodontic Society. Before after treatment, self-assessed masticatory ability oral health-related quality life (OHRQoL) examined, authors compared them according Mann-Whitney U test. To compare findings before used Wilcoxon signed rank...
This study aimed to investigate the factors associated with periodontal traits considering genetic and environmental background in predominantly older female twins.This was a cross-sectional using self-reported questionnaires for TwinsUK. Age-adjusted age-stratified multivariate analyses were conducted all twins. Subsequently, co-twin control analysis within genetically identical twins who discordant performed by controlling confounders.Data of aged 20-91 available 4,143 individuals...
Context: The rapid provision of high.quality complete dentures is an unmet clinical need in some populations. Novel procedures may simplify this service but require validation against existing methods. Aims: aim trial was to evaluate the acceptability fabricated using biofunctional prosthetic system. (BPS) when compared with conventional Materials and Methods: This study designed as a crossover trial. patients wore either denture, which made system denture (BPSCD) or (CCD) for 3. months...
Objective Although researchers have recently demonstrated a relationship between oral health and arterial sclerosis, the genetic contribution to this has been ignored even though factors are expected some effect on various diseases. The aim of study was evaluate as significant risk factor related sclerosis after eliminating confounding through older Japanese twins. Subjects Methods Medical dental surveys were conducted individually for 106 twin pairs over age 50 years. Maximal carotid...
The use of periodontal biomarkers for identification and monitoring unique patient populations could foster better stratification at-risk groups, increase access to treatment those most in need, facilitate preventive measures improve personalised care plans. aim this study was examine the diagnostic prognostic utility oral lipopolysaccharides as bacterially-derived biomarkers.Periodontal parameters were recorded, saliva subgingival plaque samples collected at beginning from periodontally...
One of the purposes prosthodontic treatment is to prevent overeruption opposing teeth, but there currently minimal literature describing efficacy removable partial dentures (RPDs) in performing this function. This study investigated following RPD treatment. The participants were 33 patients treated with RPDs, and was evaluated by comparing surface computeraided design data dental casts made at two different time points-before after Overeruption observed 38.1% teeth opposed RPD, which much...
Tooth loss is a common health concern in older adults. We aimed to estimate the relative contributions of genetic and environmental factors variation number teeth middle-aged populations using population-based cohort Danish twins. The study included 5,269 or twins who provided data on at baseline by structured interviews. were analyzed univariate liability threshold modeling, stratified sex age, familial risk tooth as well estimates heritability. In whole cohorts, 23% participants edentate...
ABSTRACT Background Genetic and environmental risk factors contribute to periodontal disease, but the underlying susceptibility pathways are not fully understood. Epigenetic mechanisms malleable regulators of gene function that can change in response genetic stimuli, thereby providing a potential mechanism for mediating effects periodontitis. The aim this study is identify epigenetic changes across tissues associated with disease. Methods Self-reported gingival bleeding history gum or tooth...
Innate and adaptive immune responses at mucosal surfaces play a role in protection against most infectious diseases. However, the relative importance either of versus systemic, or cellular humoral immunity such infections remains unclear. We aimed to determine percentages reproducibility detection major T lymphocyte phenotypes stimulated whole mouth fluid (SWMF); compare matched blood phenotypes; evaluate consistency SWMF over time; any associations with age gender. Peripheral samples were...
Innate and adaptive immune responses at mucosal surfaces play a role in protection against most infectious diseases. However, the relative importance either of versus systemic, or cellular humoral immunity such infections remains unclear. We aimed to determine percentages reproducibility detection five major T lymphocyte phenotypes stimulated whole mouth fluid (SWMF); compare matched blood phenotypes; evaluate consistency SWMF over time; any associations with age gender. Peripheral samples...