Julia S. El-Sayed Moustafa
A5073027388- Genetic Associations and Epidemiology
- Epigenetics and DNA Methylation
- Long-Term Effects of COVID-19
- Genomic variations and chromosomal abnormalities
- Dental Health and Care Utilization
- Pediatric health and respiratory diseases
- RNA modifications and cancer
- COVID-19 Clinical Research Studies
- Genetics and Neurodevelopmental Disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Genomics and Rare Diseases
- COVID-19 and Mental Health
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Nutrition, Genetics, and Disease
- Adipose Tissue and Metabolism
- Congenital heart defects research
- GDF15 and Related Biomarkers
- Renal Diseases and Glomerulopathies
- Fibroblast Growth Factor Research
- Oral microbiology and periodontitis research
- Regulation of Appetite and Obesity
- Heavy Metal Exposure and Toxicity
- Machine Learning in Healthcare
- Diet and metabolism studies
- Kruppel-like factors research
King's College London
2016-2025
St Thomas' Hospital
2016-2025
Augusta University Health
2022
Imperial College London
2010-2016
Genomics (United Kingdom)
2011-2016
Genomics England
2011-2016
Hammersmith Hospital
2010-2014
Royal Free London NHS Foundation Trust
2012
University College London
2012
Finnish Institute for Health and Welfare
2012
A total of 2,618,862 participants reported their potential symptoms COVID-19 on a smartphone-based app. Among the 18,401 who had undergone SARS-CoV-2 test, proportion loss smell and taste was higher in those with positive test result (4,668 7,178 individuals; 65.03%) than negative (2,436 11,223 participants; 21.71%) (odds ratio = 6.74; 95% confidence interval 6.31-7.21). model combining to predict probable infection applied data from all app users (805,753) predicted that 140,312 (17.42%)...
Abstract Importance A strategy for preventing further spread of the ongoing COVID-19 epidemic is to detect infections and isolate infected individuals without need extensive bio-specimen testing. Objectives Here we investigate prevalence loss smell taste among diagnosed identify combination symptoms, besides taste, most likely correspond a positive diagnosis in non-severe cases. Design Community survey. Setting Participants Subscribers RADAR COVID-19, an app that was launched use UK general...
As no one symptom can predict disease severity or the need for dedicated medical support in coronavirus 2019 (COVID-19), we asked whether documenting time series over first few days informs outcome. Unsupervised clustering presentation was performed on data collected from a training dataset of completed cases enlisted early COVID Symptom Study Smartphone application, yielding six distinct presentations. Clustering validated an independent replication between 1 and 28 May 2020. Using 5...
Background The association between current tobacco smoking, the risk of developing symptomatic COVID-19 and severity illness is an important information gap. Methods UK users Zoe Symptom Study app provided baseline data including demographics, anthropometrics, smoking status medical conditions, were asked to log their condition daily. Participants who reported that they did not feel physically normal then by complete a series questions, 14 potential symptoms about hospital attendance. main...
Frailty, increased vulnerability to physiological stressors, is associated with adverse outcomes. COVID-19 exhibits a more severe disease course in older, comorbid adults. Awareness of atypical presentations critical facilitate early identification.
Males and females differ in body composition fat distribution. Using a mouse model that segregates gonadal sex (ovaries testes) from chromosomal (XX XY), we showed XX chromosome complement combination with high-fat diet led to enhanced weight gain the presence of male or female gonads. We identified genomic dosage Kdm5c, an X gene escapes inactivation, as determinant effect on adiposity. Modulating Kdm5c mice levels are normally present males resulted reduced weight, content, food intake...
Adipose tissue is an important endocrine organ with a role in many cardiometabolic diseases. It comprised of heterogeneous collection cell types that can differentially impact disease phenotypes. Cellular heterogeneity also confound -omic analyses but rarely taken into account analysis solid-tissue transcriptomes. Here, we investigate cell-type two population-level subcutaneous adipose-tissue RNA-seq datasets (TwinsUK, n = 766 and the Genotype-Tissue Expression project [GTEx], 326) by...
Abstract As no one symptom can predict disease severity or the need for dedicated medical support in COVID-19, we asked if documenting time series over first few days informs outcome. Unsupervised clustering presentation was performed on data collected from a training dataset of completed cases enlisted early COVID Symptom Study Smartphone application, yielding six distinct presentations. Clustering validated an independent replication between May 1-May 28 th , 2020. Using 5 logging, ROC-AUC...
Abstract Fat distribution is an independent cardiometabolic risk factor. However, its molecular and cellular underpinnings remain obscure. Here we demonstrate that two GWAS signals at RSPO3 , which are associated with increased body mass index-adjusted waist-to-hip ratio, act to specifically increase expression in subcutaneous adipocytes. These variants also reduced lower-body fat, enlarged gluteal adipocytes insulin resistance. Based on human studies may limit gluteofemoral adipose tissue...
X-chromosome inactivation (XCI) silences one X in female cells to balance sex-differences X-dosage. A subset of X-linked genes escape XCI, but the extent which this phenomenon occurs and how it varies across tissues a population is as yet unclear. To characterize incidence variability individuals tissues, we conducted transcriptomic study adipose, skin, lymphoblastoid cell lines immune 248 healthy exhibiting skewed XCI. We quantify XCI from linear model genes' allelic fold-change XIST-based...
Genetic and environmental risk factors contribute to periodontal disease, but the underlying susceptibility pathways are not fully understood. Epigenetic mechanisms malleable regulators of gene function that can change in response genetic stimuli, thereby providing a potential mechanism for mediating effects periodontitis. The aim this study is identify epigenetic changes across tissues associated with disease. Self-reported gingival bleeding history gum or tooth mobility, were used as...
Obesity in humans and mice is associated with elevated levels of two hormones responsive to cellular stress, namely GDF15 FGF21. Over-expression each these weight loss beneficial metabolic changes but where they are secreted from what required for physiologically the context overfeeding remains unclear. Here we used tissue selective knockout mouse models human transcriptomics determine source circulating obesity. We then generated characterized phenotypes GDF15/FGF21 double mice. Circulating...
Background: Ageing is a heterogenous process characterised by cellular and molecular hallmarks, including changes to haematopoietic stem cells primary risk factor for chronic diseases. X chromosome inactivation (XCI) randomly transcriptionally silences either the maternal or paternal in each cell of 46, XX females balance gene expression with XY males. Age acquired XCI-skew describes preferential selection across tissue resulting an imbalance XCI, which particularly prevalent blood tissues...
Abstract Background Perfluorooctanoic acid (PFOA) and Perfluorooctanesulfonic Acid (PFOS) are synthetic substances with long half-lives. Their presence is widespread pervasive, they noted for their environmental persistence. Research has shown these chemicals to be associated dyslipidaemia, although few studies have considered the long-term associations in general population. Objectives The aim of this study was consider longitudinal cross-sectional lipid phenotypes. Methods We investigated...