A5091749752- Bariatric Surgery and Outcomes
- Healthcare Policy and Management
- Public Health Policies and Education
- Medical Malpractice and Liability Issues
- Obesity and Health Practices
- Diet and metabolism studies
- Primary Care and Health Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Global Public Health Policies and Epidemiology
- Healthcare cost, quality, practices
- Cardiovascular Disease and Adiposity
- Adipose Tissue and Metabolism
- Genetic Associations and Epidemiology
- Smoking Behavior and Cessation
- Metabolism, Diabetes, and Cancer
- Lexicography and Language Studies
- Legal Systems and Judicial Processes
- Body Contouring and Surgery
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes Treatment and Management
- Ethics in medical practice
- Law, Economics, and Judicial Systems
- Cancer Risks and Factors
- Ethics in Clinical Research
- Legal principles and applications
University of Gothenburg
2016-2025
University of Michigan
2013-2022
National Health Law Program
2020-2022
National Academy of Medicine
2020
Washington College
2019
Trinity College
2019
Jacobs (United States)
1998-2018
Centre Hospitalier de Béziers
2018
Robert Wood Johnson Foundation
1997-2017
ChangeLab Solutions
2017
Obesity is associated with increased mortality. Weight loss improves cardiovascular risk factors, but no prospective interventional studies have reported whether weight decreases overall In fact, many observational suggest that reduction mortality.The prospective, controlled Swedish Obese Subjects study involved 4047 obese subjects. Of these subjects, 2010 underwent bariatric surgery (surgery group) and 2037 received conventional treatment (matched control group). We report on mortality...
Obesity is a risk factor for cardiovascular events. Weight loss might protect against events, but solid evidence lacking.To study the association between bariatric surgery, weight loss, and events.The Swedish Obese Subjects (SOS) an ongoing, nonrandomized, prospective, controlled conducted at 25 public surgical departments 480 primary health care centers in Sweden of 2010 obese participants who underwent surgery 2037 contemporaneously matched controls received usual care. Patients were...
Short-term studies show that bariatric surgery causes remission of diabetes. The long-term outcomes for and diabetes-related complications are not known.To determine the diabetes rates cumulative incidence microvascular macrovascular after surgery.The Swedish Obese Subjects (SOS) is a prospective matched cohort study conducted at 25 surgical departments 480 primary health care centers in Sweden. Of patients recruited between September 1, 1987, January 31, 2001, 260 2037 control 343 2010 had...
Weight loss protects against type 2 diabetes but is hard to maintain with behavioral modification alone. In an analysis of data from a nonrandomized, prospective, controlled study, we examined the effects bariatric surgery on prevention diabetes.In this analysis, included 1658 patients who underwent and 1771 obese matched controls (with matching performed group, rather than individual, level). None participants had at baseline. Patients in bariatric-surgery cohort banding (19%), vertical...
Obesity shortens life expectancy. Bariatric surgery is known to reduce the long-term relative risk of death, but its effect on expectancy unclear.We used Gompertz proportional hazards regression model compare mortality and among patients treated with either bariatric (surgery group) or usual obesity care (control in prospective, controlled Swedish Obese Subjects (SOS) study participants SOS reference (reference cohort), a random sample from general population.In total, 2007 2040 were...
Conventional cardiac pacemakers are associated with several potential short- and long-term complications related to either the transvenous lead or subcutaneous pulse generator. We tested safety clinical performance of a novel, completely self-contained leadless pacemaker.The primary end point was freedom from at 90 days. Secondary points included implant success rate, time, measures device (pacing/sensing thresholds rate-responsive performance). The mean age patient cohort (n=33) 77±8 years,...
Obesity is a risk factor for atrial fibrillation, which in turn associated with stroke, heart failure, and increased all-cause mortality. The authors investigated whether weight loss through bariatric surgery may reduce the of new-onset fibrillation. SOS (Swedish Obese Subjects) prospective matched cohort study conducted at 25 surgical departments 480 primary healthcare centers Sweden. was recruited between 1987 2001. Among 4,021 obese individuals sinus rhythm no history 2,000 underwent...
Ghrelin and preproghrelin sequences were determined in 96 unrelated female subjects with severe obesity (mean body mass index (BMI) 42.3 +/- 3.4 kg/m(2)) non-obese controls BMI 23.0 1.4 (kg/m2) of the Swedish Obese Subjects cohort. A mutation at amino acid position 51 (Arg51Gln) sequence that corresponds to last mature ghrelin product was identified six (all heterozygotes) obese (6.3%) but not among (p < 0.05). The self-reported weight 20, 30, 40 years age tended be 7.5, 4.7 6.4 kg lower,...
Abstract Objective: Associations between preproghrelin DNA variants and obesity‐related phenotypes were studied in 3004 subjects from the Québec Family Study (QFS), HERITAGE (HERITAGE), Swedish Obese Subjects (SOS) Study. Research Methods Procedures: Body mass index (BMI), fat (FM) underwater weighing, abdominal computerized tomography measured. The ghrelin polymorphisms identified by polymerase chain reaction. Results: Arg51Gln QFS ( n = 6) had lower concentrations p 0.007) than Arg51Arg...
Objective Increased sensitivity to alcohol after gastric bypass has been described. The aim of this study was investigate whether bariatric surgery is associated with problems. Design and Methods prospective, controlled Swedish Obese Subjects (SOS) enrolled 2,010 obese patients who underwent (68% vertical banded gastroplasty (VBG), 19% banding, 13% bypass) 2,037 matched controls. Patients were recruited between 1987 2001. Data on abuse diagnoses, self‐reported consumption, problems obtained...
OBJECTIVE Obese individuals with type 2 diabetes have an increased risk of cardiovascular disease. The effect bariatric surgery on events in obese remains to be determined. Swedish Subjects (SOS) study is a prospective, controlled intervention that examines the effects hard end points. aim present was examine SOS participants diabetes. RESEARCH DESIGN AND METHODS All at baseline were included analyses (n = 345 group and n 262 control group). Mean follow-up 13.3 years (interquartile range...
Public engagement in ethically laden pandemic planning decisions may be important for transparency, creating public trust, improving compliance with health orders, and ultimately, contributing to just outcomes. We conducted focus groups members of the characterize perceptions about social distancing measures likely implemented during a pandemic. Participants expressed concerns job security economic strain on families if businesses or school closures are prolonged. They shared opposition...
Cholecystokinin (CCK) decreases meal size through activation of CCK-A receptors on vagal afferents. We tested the hypothesis that selective agonist GI181771X induces weight loss in obese patients. Patients with body mass index ≥30 or ≥27 kg/m2 concomitant risk factors were randomized to 24-week, double-blind treatment different doses matching placebo together a hypocaloric diet. The primary efficacy end point was absolute change weight. To monitor pancreatic and gallbladder effects, patients...
Men and women differ in body fat distribution adipose tissue metabolism as well obesity comorbidities their response to treatment.The objective of the study was a search for sex differences function.This an exploratory performed at university hospital.Resting metabolic rate (RMR), composition, sc genome-wide expression were measured SOS Sib Pair (n = 732).The relative contribution mass RMR per kilogram higher than men (P value by interaction .0019). Women had increased genes involved...