A5015881911- Bariatric Surgery and Outcomes
- Diet and metabolism studies
- Muscle metabolism and nutrition
- Diabetes Treatment and Management
- Pharmacology and Obesity Treatment
- Regulation of Appetite and Obesity
- Obesity and Health Practices
- Nutrition and Health in Aging
- Adipose Tissue and Metabolism
- Renal Transplantation Outcomes and Treatments
- Body Composition Measurement Techniques
- Genetic Associations and Epidemiology
- Growth Hormone and Insulin-like Growth Factors
- Hormonal and reproductive studies
- Body Contouring and Surgery
- Sports Performance and Training
- Biochemical Analysis and Sensing Techniques
- Pharmacological Effects and Toxicity Studies
- Dialysis and Renal Disease Management
- Obesity, Physical Activity, Diet
- Esophageal and GI Pathology
- Metabolism and Genetic Disorders
- Neurological and metabolic disorders
- Parathyroid Disorders and Treatments
- Dietary Effects on Health
University of Bern
1992-2021
University of Liechtenstein
2013-2016
Kantonsspital Winterthur
2011
Linde (United States)
2008
Klinik Hirslanden
1998-2008
Winterthur Museum Garden and Library
2008
State University of New York
2004
Max Planck Institute for Molecular Genetics
2004
SUNY Downstate Health Sciences University
2004
Zimmer (Switzerland)
2001
Prednisone treatment causes protein wasting and adds additional risks to a patient, whereas human growth hormone (hGH) positive nitrogen balance. To determine whether concomitant administration of hGH prevents the catabolic effects prednisone, four groups eight healthy volunteers each were studied using isotope dilution balance techniques after 7 d placebo, alone (0.1 mg.kg-1.d-1), prednisone (0.8 or plus (n = 8 in group). Whether was calculated from leucine kinetic data values, induced (P...
Obesity, a multifactorial disease caused by the interaction of genetic factors with environment, is largely polygenic. A few mutations in these genes, such as leptin receptor (LEPR) gene and melanocortin 4 (MC4R) gene, have been identified causes monogenic obesity.We sequenced complete MC4R coding region, region proopiomelanocortin (POMC) encoding alpha melanocyte-stimulating hormone, leptin-binding domain LEPR 469 severely obese white subjects (370 women 99 men; mean [+/-SE] age, 41.0+/-0.5...
Melanocortin-4 receptor (MC4R) deficiency is the most frequent genetic cause of obesity. However, there uncertainty regarding degree penetrance this condition, and putative impact environment on development obesity in MC4R mutation carriers unknown.We determined sequence 2,257 obese individuals 2,677 nonobese control subjects European origin established likely functional all variants detected. We then included relatives probands studied 25 pedigrees, including 97 94 noncarriers from three...
Renal transplant patients exhibit increased rates of trabecular bone fractures, probably due to glucocorticoid-induced osteopenia, which is known occur within 6 months after kidney grafting. This mineral loss at a mostly site (lumbar spine) contrasts with gain the radius, consists mainly cortical bone. However, early effects transplantation on other parts human skeleton and time course these changes during first 5 remain unknown. Therefore, 34 recipients were prospectively followed...
To define whether laparoscopic gastric banding or Roux-en-Y bypass represents the better approach to treat patients with morbid obesity.
The melanocortin-4 receptor (MC4R) gene pathogenic mutations are the most prevalent forms of monogenic obesity, responsible for ∼2% obesity cases, but its role in common is still elusive. We analyzed contribution non-synonymous V103I (rs2229616, c.307G > A) and I251L (no rs, c.751A C) to 16 797 individuals European origin from nine independent case–control, population-based familial cohorts. observed a consistent negative association variant (prevalence ranging 0.41–1.21%) with both...
In 2005, for the first time in European history, an extraordinary expert panel named BSCG (Bariatric Scientific Collaborative Group), was appointed through joint effort of major scientific societies which are active field obesity management. Societies that constituted this were: IFSO – International Federation Surgery Obesity, IFSO-EC Obesity Chapter, EASO Association Study ECOG Childhood Group, together with IOTF (International Task Force) represented during completion process by its...
Sim1 haploinsufficiency in mice induces hyperphagic obesity and developmental abnormalities of the brain. In humans, chromosome 6q16, a region that includes SIM1, were reported obese children with Prader-Willi-like syndrome; however, SIM1 involvement has never been conclusively demonstrated. Here, was sequenced 44 syndrome features, 198 severe early-onset obesity, 568 morbidly adults, 383 controls. We identified 4 rare variants (p.I128T, p.Q152E, p.R581G, p.T714A) features (including...
To define whether laparoscopic rebanding or Roux-en-Y gastric bypass represents the best approach for failed banding in patients with morbid obesity.
To evaluate the influence of hydration status on estimation body composition using dual-energy X-ray absorptiometry (DXA), six normal volunteers and seven patients maintenance haemodialysis were investigated two different DXA machines (Lunar DPX, Hologic QDR 1000/W). Normal studied (Hologic 1000/W) before 1 h after ingestion breakfast, lunch dinner (drinking various amounts liquids at each meal, 0.5-2.4 kg). Whereas bone mineral content fat mass did not change, lean trunk increased as a...
The present studies were performed to test the hypothesis that liver, by increasing synthesis of specific plasma proteins during absorption an amino acid meal, may play important role in temporary "storage" ingested essential acids and explore effects glucocorticosteroids recombinant human growth hormone (rhGH) on these processes. fractional synthetic rates albumin fibrinogen determined using simultaneous infusions intravenous [1-14C]leucine intraduodenal [4,5-3H]leucine after 22 h fasting...
Considering that a portion of the heterogeneity amongst previous replication studies may be due to variable proportion obese subjects in case-control designs, we assessed association genetic variants with type 2 diabetes (T2D) large groups and non-obese subjects.We genotyped RETN, KCNJ11, HNF4A, HNF1A, GCK, SLC30A8, ENPP1, ADIPOQ, PPARG, TCF7L2 polymorphisms 1,283 normoglycemic (NG) 1,581 T2D individuals as well 3,189 NG 1,244 European descent, allowing us examine risk over wide range...
Treatment with glucocorticoids causes wasting of proximal skeletal muscles. There is evidence that physical training improves muscle mass and strength in glucocorticoidtreated rats. Whether this also true humans not known. The present investigation was designed to establish what respect moderate may alter function as assessed quantitatively by computed tomography (CT) an isokinetic dynamometer (Cybex II). Compared withmatched normal subjects (n = 12), patients 12) treated prednisone [12.6 ±...
We previously proposed that, during the infusion of either labeled leucine or its alpha-ketoacid, alpha-ketoisocaproate (KIC), plasma specific activity (SA) transaminated product infused tracer ("reciprocal pool SA") may better reflect intracellular SA than ("primary SA"). To test this hypothesis, 14 dogs were simultaneously intravenously with [3H]leucine and [14C]KIC, blood tissue compartments sampled. The ratios [3H]-leucine to [14C]leucine [( 3H]/[14C]leucine) in mixed proteins space...
The therapeutic effects of cannabinoid receptor blockade on obesity-associated phenotypes underline the importance endocannabinoid pathway energy balance. Using a staged-approach, we examined contribution 1 gene ( CNR1 ) obesity and body mass index (BMI) in European population. With input exons 3′ 5′ regions sequencing HapMap database, selected genotyped 26 tagging single-nucleotide polymorphisms (SNPs) 1932 obese cases 1173 non-obese controls French origin. Variants that showed significant...
Null mutations in the PCSK1 gene, encoding proprotein convertase 1/3 (PC1/3), cause recessive monogenic early onset obesity. Frequent coding variants that modestly impair PC1/3 function mildly increase risk for common The aim of this study was to determine contribution rare functional exons were sequenced 845 nonconsanguineous extremely obese Europeans. Eight novel nonsynonymous identified, all heterozygous. Seven had a deleterious effect on either maturation or enzymatic activity cell...