A5001875542- Bariatric Surgery and Outcomes
- Diet and metabolism studies
- Genetic Associations and Epidemiology
- Diabetes Treatment and Management
- Obesity, Physical Activity, Diet
- Regulation of Appetite and Obesity
- Gestational Diabetes Research and Management
- Liver Disease Diagnosis and Treatment
- Eating Disorders and Behaviors
- Health, Medicine and Society
- Nutritional Studies and Diet
- Body Contouring and Surgery
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nutrition and Health in Aging
- Adipose Tissue and Metabolism
- Healthcare Systems and Practices
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Obesity and Health Practices
- Lipoproteins and Cardiovascular Health
- Nutrition, Genetics, and Disease
- Biochemical Analysis and Sensing Techniques
- Tryptophan and brain disorders
- Aging, Elder Care, and Social Issues
Population Health Research Institute
2018-2025
McMaster University
2016-2025
University College South Denmark
2024
Virginia Commonwealth University
2024
University of British Columbia
2024
Universidad de La Frontera
2024
University of Arizona
2024
University of California, San Francisco
2024
Hamilton Health Sciences
2019-2024
Thrombosis and Atherosclerosis Research Institute
2019-2024
Objective This study characterized the kynurenine pathway (KP) in human obesity by evaluating circulating levels of kynurenines and expression KP enzymes adipose tissue. Methods Tryptophan metabolite were measured serum individuals from D.E.S.I.R. cohort (case–cohort study: 212 diabetic, 836 randomly sampled) women with obesity, diabetic or normoglycemic, ABOS ( n = 100). enzyme gene expressions analyzed omental subcutaneous tissue cohort, primary adipocytes monocyte‐derived macrophages....
In Brief Objectives: To compare the long-term benefit of gastric bypass [Roux-en-Y (RYGB)] versus adjustable banding (AGB) on nonalcoholic fatty liver disease (NAFLD) in severely obese patients. Background: NAFLD improves after weight loss surgery, but no histological study has compared effects various bariatric interventions. Methods: Participants consisted 1236 patients (body mass index = 48.4 ± 7.6 kg/m2), enrolled a prospective longitudinal for up to 5 years RYGB (n 681) or AGB 555)....
Angiotensin-converting enzyme 2 (ACE2) is an endogenous counter-regulator of the renin-angiotensin hormonal cascade. We assessed whether plasma ACE2 concentrations were associated with greater risk death or cardiovascular disease events.We used data from Prospective Urban Rural Epidemiology (PURE) prospective study to conduct a case-cohort analysis within subset PURE participants (from 14 countries across five continents: Africa, Asia, Europe, North America, and South America). measured...
Mitochondrial DNA copy number (mtDNA-CN) is an accessible blood-based measurement believed to capture underlying mitochondrial (MT) function. The specific biological processes underpinning its regulation, and whether those are causative for disease, area of active investigation.
Atrial fibrillation (AF) is a cardiac arrhythmia associated with an elevated risk of stroke, heart failure, and mortality. However, preventative therapies are needed ancillary benefits on its cardiovascular comorbidities. Lipoprotein(a) (Lp[a]) recognized factor for atherosclerotic disease (ASCVD), which itself increases AF risk, but it remains unknown whether Lp(a) causal mediator independent ASCVD.This study investigated the role in ASCVD.Measured genetically predicted levels were tested...
Body mass index (BMI) is an easily obtained adiposity surrogate. However, there variability in body composition and adipose tissue distribution between individuals with the same BMI, controversy regarding BMI associated lowest mortality risk.To evaluate which of fat (FMI), waist-to-hip (WHR) has strongest most consistent association mortality.This cohort study used incident deaths from UK Biobank (UKB; 2006-2022), includes data 22 clinical assessment centers across United Kingdom. UKB...
Novel, effective, and safe drugs are warranted for treatment of ischemic stroke. Circulating protein biomarkers with causal genetic evidence represent promising drug targets, but no systematic screen the proteome has been performed.First, using Mendelian randomization (MR) analyses, we assessed 653 circulating proteins as possible mediators 3 different subtypes stroke: large artery atherosclerosis, cardioembolic stroke, small occlusion. Second, used MR to assess whether identified also...
Human obesity is characterized by chronic low-grade inflammation in white adipose tissue and often associated with hypertension. The potential induction of indoleamine 2,3-dioxygenase-1 (IDO1), the rate-limiting enzyme tryptophan/kynurenine degradation pathway, proinflammatory cytokines, could be these disorders but has remained unexplored obesity. Using immunohistochemistry, we detected IDO1 expression obese patients, focused on its contribution regulation vascular tone immunoregulatory...
Background Epidemiological studies have reported conflicting findings on the potential adverse effects of long-term antihypertensive medication use cancer risk. Naturally occurring variation in genes encoding drug targets can be used as proxies for these to examine effect their therapeutic inhibition disease outcomes. Methods and We performed a mendelian randomization analysis association between genetically proxied 3 risk 4 common cancers (breast, colorectal, lung, prostate)....
Mutations of the monocarboxylate transporter 8 (MCT8) gene determine a distinct X-linked phenotype severe psychomotor retardation and consistently elevated T(3) levels. Lack MCT8 transport in neurons could explain neurological phenotype.Our objective was to whether high levels also contribute some critical features observed these patients.A 16-yr-old boy with hypotonia hospitalized for malnutrition (body weight = 25 kg) delayed puberty. He had tachycardia (104 beats/min), SHBG level (261...
Null mutations in the PCSK1 gene, encoding proprotein convertase 1/3 (PC1/3), cause recessive monogenic early onset obesity. Frequent coding variants that modestly impair PC1/3 function mildly increase risk for common The aim of this study was to determine contribution rare functional exons were sequenced 845 nonconsanguineous extremely obese Europeans. Eight novel nonsynonymous identified, all heterozygous. Seven had a deleterious effect on either maturation or enzymatic activity cell...
Background Liver biopsy is considered as the gold standard for assessing nonalcoholic fatty liver disease (NAFLD) histologic lesions in patients with morbid obesity. The aim of this study was to determine diagnostic utility noninvasive markers fibrosis (FibroTest), steatosis (SteatoTest), and steatohepatitis (NashTest, ActiTest) these patients. Materials methods Two hundred eighty-eight presenting interpretable baseline operative biomarkers, an ongoing prospective cohort treated bariatric...
In type 2 diabetes (T2D), hepatic insulin resistance is strongly associated with nonalcoholic fatty liver disease (NAFLD). this study, we hypothesized that the DNA methylome of livers from patients T2D compared individuals normal plasma glucose levels can unveil some mechanism could link to NAFLD. Using and transcriptome analyses obese individuals, found hypomethylation at a CpG site in PDGFA (encoding platelet-derived growth factor α) overexpression are both increased risk,...
Salivary (AMY1) and pancreatic (AMY2) amylases hydrolyze starch. Copy number of AMY1A (encoding AMY1) was reported to be higher in populations with a high-starch diet reduced obese people. These results based on quantitative PCR have been challenged recently. We aimed re-assess the relationship between amylase adiposity using systems biology approach.We assessed association plasma enzymatic activity AMY1 or AMY2, several metabolic traits almost 4000 French individuals from D.E.S.I.R....