A5029393034- Tryptophan and brain disorders
- Pharmacogenetics and Drug Metabolism
- Poisoning and overdose treatments
- Diet and metabolism studies
- Forensic Toxicology and Drug Analysis
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Blood transfusion and management
- Stress Responses and Cortisol
- Veterinary Pharmacology and Anesthesia
- Orthopedic Infections and Treatments
- Colorectal Cancer Treatments and Studies
- Biochemical and Molecular Research
- Cancer Immunotherapy and Biomarkers
- Pesticide Exposure and Toxicity
- Metabolism and Genetic Disorders
- Antibiotics Pharmacokinetics and Efficacy
- Opioid Use Disorder Treatment
- Pharmacological Effects and Toxicity Studies
- Pharmaceutical studies and practices
- Maternal and fetal healthcare
- Vitamin D Research Studies
- Prenatal Substance Exposure Effects
- Antifungal resistance and susceptibility
- Renal Transplantation Outcomes and Treatments
- Pancreatic and Hepatic Oncology Research
Centre Hospitalier Universitaire de Lille
2015-2024
Université de Lille
2013-2024
IMPact de l'Environnement Chimique sur la Santé humaine
2016-2024
Inserm
2023
Institut de Biologie de Lille
2011-2023
Institut Pasteur de Lille
2021
Université Lille Nord de France
2011-2019
Centre Oscar Lambret
2018
Fraunhofer Institute for Toxicology and Experimental Medicine
2015
Centre Hospitalier Universitaire de Martinique
2014
Objective This study characterized the kynurenine pathway (KP) in human obesity by evaluating circulating levels of kynurenines and expression KP enzymes adipose tissue. Methods Tryptophan metabolite were measured serum individuals from D.E.S.I.R. cohort (case–cohort study: 212 diabetic, 836 randomly sampled) women with obesity, diabetic or normoglycemic, ABOS ( n = 100). enzyme gene expressions analyzed omental subcutaneous tissue cohort, primary adipocytes monocyte‐derived macrophages....
Human obesity is characterized by chronic low-grade inflammation in white adipose tissue and often associated with hypertension. The potential induction of indoleamine 2,3-dioxygenase-1 (IDO1), the rate-limiting enzyme tryptophan/kynurenine degradation pathway, proinflammatory cytokines, could be these disorders but has remained unexplored obesity. Using immunohistochemistry, we detected IDO1 expression obese patients, focused on its contribution regulation vascular tone immunoregulatory...
In melanoma, both the induction of immunosuppression by tumor cells and inflammatory antitumor response can induce an upregulation counter-regulatory mechanisms such as indoleamine 2,3-dioxygenase (IDO), programmed death-ligand 1 (PD-L1) CTLA-4+ regulatory T-cells (Tregs) in microenvironment. Even though these immunosuppressive mediators are targets for immunotherapy, research investigating their expression peripheral blood is lacking. We therefore, performed flow cytometry on PBMCs stage...
The gut-to-lung axis is critical during respiratory infections, including influenza A virus (IAV) infection. In the present study, we used high-resolution shotgun metagenomics and targeted metabolomic analysis to characterize influenza-associated changes in composition metabolism of mouse gut microbiota. We observed several taxonomic-level on day (D)7 post-infection, a marked reduction abundance members Lactobacillaceae Bifidobacteriaceae families, an increase Akkermansia muciniphila. On...
Variability in genes involved drug pharmacokinetics or response can be responsible for suboptimal treatment efficacy predispose to adverse reactions. In addition common genetic variations, large-scale sequencing studies have uncovered multiple rare variants predicted cause functional alterations encoding proteins implicated metabolism, transport and response. To understand the importance of DPYD, a pharmacogene whose severe toxicity patients exposed fluoropyrimidine-based regimens, massively...
Pseudomonas aeruginosa (Pa) is a Gram-negative bacteria frequently involved in healthcare-associated pneumonia with poor clinical outcome. To face the announced post-antibiotic era due to increasing resistance and lack of new antibiotics, treatment strategies have be developed. Immunomodulation host response outcome could an alternative therapeutic target Pa-induced lung infection. Kynurenines are metabolites resulting from tryptophan catabolism known for their immunomodulatory properties....
The optimal dose of tranexamic acid to inhibit hyperfibrinolysis in postpartum haemorrhage is unclear. Tranexamic Acid Reduce Blood Loss Hemorrhagic Cesarean Delivery (TRACES) was a double-blind, placebo-controlled, randomised, multicentre dose-ranging study determine the dose-effect relationship for two regimens intravenous vs placebo.Women experiencing during Caesarean delivery were randomised receive placebo (n=60), 0.5 g (n=57), or 1 i.v. (n=58). Biomarkers fibrinolytic activation...
Limited pharmacokinetics data support dalbavancin long-term use in off-label indications and the optimal dosing regimen is debated. We aimed to describe concentrations an observational retrospective multicentre study.
An increase of plasma kynurenine concentrations, potentially bioactive metabolites tryptophan, was found in subjects with obesity, resulting from low-grade inflammation the white adipose tissue. Bariatric surgery decreases associated obesity and improves glucose control.Our goal to determine concentrations all after bariatric whether they were correlated control improvement.Kynurenine metabolite analysed by liquid or gas chromatography coupled tandem mass spectrometry, circulating...
Background Indoleamine 2,3-dioxygenase (IDO) catalyzes the first and rate-limiting step of kynurenine pathway that is an important component immunomodulatory neuromodulatory processes. The IDO1 gene highly inducible by IFN-γ TNF-α through interaction with cis-acting regulatory elements promoter region. Accordingly, functional polymorphisms in could partly explain interindividual variability IDO expression has been previously documented. Methodology/Principal Findings A PCR-sequencing...
Abstract Introduction In April 2019, French authorities mandated dihydropyrimidine dehydrogenase (DPD) screening, specifically testing uracilemia, to mitigate the risk of toxicity associated with fluoropyrimidine‐based chemotherapy. However, this subject is still debate as there no consensus on a standardized DPD deficiency screening test. We conducted real‐life retrospective study aim assessing impact occurrence severe and exploring potential benefits complete genotyping using...
Evidence increases that a high or standard dose of tranexamic acid (TA) reduces postpartum bleeding. The TRACES pharmacobiological substudy aims to establish therapeutic strategy in hemorrhagic (H) Cesarean section (CS) with respect the intensity fibrinolysis by using innovative assays.The trial is multicenter, randomized, double-blind, placebo-controlled, TA dose-ranging study measures simultaneously plasmatic and uterine urine concentrations plasmin peak inhibition tested simultaneous...
The aim of this study was to evaluate the population pharmacokinetics tranexamic acid (TXA) administered intravenously at a single dose 0.5 or 1 g in parturients undergoing active hemorrhagic cesarean delivery and influence patient variables on TXA pharmacokinetics. Subjects from three recruiting centers were included PK sub-study if randomized experimental group (i.v over one minute) TRACES study. Blood samples two urinary collected within 6 h after injection. Parametric non-linear...
Abstract Nasopharyngeal carcinoma‐derived small extracellular vesicles (NPCSEVs) have an immunosuppressive impact on the tumour microenvironment. In this study, we investigated their influence generation of tolerogenic dendritic cells and potential involvement galectin‐9 (Gal9) they carry in process. We analysed phenotype properties NPCSEVs explored ability DCs exposed to (NPCSEV‐DCs) regulate T cell proliferation. To assess at pathophysiological level, performed real‐time fluorescent...
Postpartum haemorrhage (PPH) is the leading cause of maternal death worldwide. Tranexamic acid (TA), an antifibrinolytic drug, reduces bleeding and transfusion need in major surgery trauma. In ongoing PPH following vaginal delivery, a high dose TA decreases volume duration, as well morbidity, while early fibrinolysis inhibited. large international trial, single reduced mortality due to but not hysterectomy rate. therapeutic dosages vary from 2.5 100 mg/kg seizures, visual disturbances nausea...
Tacrolimus (FK506) is an immunosuppressant that experiencing a continuous rise in usage worldwide. The related side effects are known to be globally dose-dependent. Despite numerous studies on FK506, the mechanisms underlying FK506 toxicity still not well understood. It therefore essential explore mediated by FK506. To accomplish this, we conducted targeted metabolomic analysis using LC-MS plasma samples of patients undergoing treatment. aim was identify any associated altered metabolic...