Anne‐Gaëlle Leroy
A5060205759- Antibiotics Pharmacokinetics and Efficacy
- Antimicrobial Resistance in Staphylococcus
- Infective Endocarditis Diagnosis and Management
- Antibiotic Resistance in Bacteria
- Orthopedic Infections and Treatments
- Bacterial Identification and Susceptibility Testing
- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Streptococcal Infections and Treatments
- Surgical site infection prevention
- Pharmacological Effects and Toxicity Studies
- Antibiotic Use and Resistance
- Tuberculosis Research and Epidemiology
- Bacterial biofilms and quorum sensing
- Orthopaedic implants and arthroplasty
- Bacteriophages and microbial interactions
- COVID-19 and healthcare impacts
- Vibrio bacteria research studies
- Infectious Diseases and Tuberculosis
- Pesticide Residue Analysis and Safety
- Infections and bacterial resistance
- Phenothiazines and Benzothiazines Synthesis and Activities
- Gut microbiota and health
- HIV, Drug Use, Sexual Risk
- Neutropenia and Cancer Infections
Centre Hospitalier Universitaire de La Réunion
2023-2024
Peuplements végétaux et bioagresseurs en milieu tropical
2018-2024
CNR de la Résistance aux Antibiotiques
2024
Nantes Université
2020-2023
Centre Hospitalier Universitaire de Nantes
2016-2023
Écologie Marine Tropicale des Océans Pacifique et Indien
2023
Naval Group (Ireland)
2020
The Enteric Nervous System in Gut and Brain Disorders
2020
Hôpital Pontchaillou
2020
Centre Hospitalier Universitaire de Poitiers
2017
Abstract Background Enterococcus faecalis infective endocarditis (EFIE) is characterized by a higher frequency of relapses than other endocarditis. The role the treatment on its occurrence remains poorly understood. aim this study was to investigate whether antibiotic regimen could impact risk relapse in EFIE. Materials This multicenter retrospective patients diagnosed with definite EFIE between 2015 and 2019 14 French hospitals. primary endpoint within year following diagnosis. As death...
The selection of a starting dose for an antidepressant, and subsequent clinical titration to appropriate therapeutic dosage, should be based on pharmacokinetic pharmacodynamic principles. In the past decade, monitoring antidepressant drugs use principles have been shown improvement over dose-response approach. Endogenous (e.g., genetic metabolic phenotype, hepatic blood flow, protein binding) exogenous factors smoking, dietary habits, concurrent medications) are capable influencing...
The management of diabetic foot infections is frequently a dead end for surgeons and infectious disease specialists. When the pathogen to be treated not resistant conventional antibiotics, latter tend unbalance intestinal microbiota, which linked multiple pathologies. A local treatment with bacteriophages, in addition being as much or even more effective than antibiotics from clinical microbiological point view, makes it possible respect patient’s microbiota. These results suggest that use...
Limited pharmacokinetics data support dalbavancin long-term use in off-label indications and the optimal dosing regimen is debated. We aimed to describe concentrations an observational retrospective multicentre study.
In the context of COVID-19 pandemic and overloaded hospitals, a central issue is need to define reliable consensual criteria for hospitalization or outpatient management in mild cases COVID-19. Our aim was an easy-to-use clinical rule aiming help emergency physicians decision-making patients with suspected confirmed SARS-CoV-2 infection (the HOME-CoV rule). The Delphi method used reach consensus large panel 51 experts: physicians, geriatricians, infectious disease specialists, ethical...
The concentrations of cefoxitin in serum and cerebrospinal fluid (CSF) were measured simultaneously three groups patients, 12 with aseptic meningitis (group 1) 17 14 bacterial (groups 2 3). patients group 1 received a single intravenous dose g without other antimicrobial therapy. In addition to conventional doses ampicillin or benzyl penicillin, 3 repeated infusions every 4 h for the first days study again on day 10. Additionally, probenecid loading followed by 0.5 6 8 h. Concentrations CSF...
The role of respiratory coinfections at diagnosis Pneumocystis jirovecii pneumonia (PcP) on clinical impact has been underestimated.A retrospective observational study was conducted January 2011 to April 2019 evaluate PcP patients in 2 tertiary care hospitals. Coinfection defined by identification pathogens from P. jirovecii-positive samples.Of 7882 samples tested for during the 8-year study, 328 with were included. Mean age 56.7 (SD 14.9) years, 193 (58.8%) male, 74 (22.6%) had positive HIV...
Abstract. Introduction: The diagnosis of prosthetic joint infections (PJIs) can be difficult in the chronic stage and is based on clinical paraclinical evidence. A minimally invasive serological test against main pathogens encountered during PJI would distinguish from mechanical loosening.Methods: We performed a prospective, multicentre, cross-sectional study to assess contribution serology PJI. Over 2-year period, all patients undergoing prosthesis revision were included study. C-reactive...
Abstract Background Amoxicillin is the first-line treatment for streptococcal or enterococcal infective endocarditis (IE) with a dose regimen adapted to weight. Objectives Covariates influencing pharmacokinetics (PK) of amoxicillin were identified in order develop dosing nomogram based on covariates individual adaptation. Patients and methods treated administered by continuous infusion IE included retrospectively. The population PK analysis was performed using Pmetrics package R (NPAG...
Bartonella species represent important causative agents of blood culture-negative infective endocarditis (IE). Their diagnosis represents a challenge for microbiologists and often relies on serological molecular tools. However, even if the sensitivity culture remains low, it should not be definitely ruled out. Indeed, we report unusual case 22 year-old Guinean homeless man diagnosed with an IE due to quintana. Unexpectedly, conventional cultures were positive after 13 days incubation....
This study aimed to assess the frequency of co-resistance antibiotics recommended in acute pyelonephritis among Escherichia coli clinical strains isolated from urinary tract infections (UTIs) acquired community or nursing homes (NHs), and identify situations without alternatives fluoroquinolones (FQs). All antimicrobial susceptibility test (AST) results E. culture-positive urine samples females living NHs, collected through a large network laboratories 2020 France, were included. The...