Cécile Le Brun

ORCID: 0000-0002-9846-0210
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About
Contact & Profiles
Research Areas
  • Pneumonia and Respiratory Infections
  • Antibiotic Resistance in Bacteria
  • Botany and Plant Ecology Studies
  • Bacterial Infections and Vaccines
  • Bacterial Identification and Susceptibility Testing
  • Infective Endocarditis Diagnosis and Management
  • Streptococcal Infections and Treatments
  • Antibiotics Pharmacokinetics and Efficacy
  • Cardiovascular, Neuropeptides, and Oxidative Stress Research
  • Antibiotic Use and Resistance
  • Apelin-related biomedical research
  • Reproductive tract infections research
  • Tuberculosis Research and Epidemiology
  • Yersinia bacterium, plague, ectoparasites research
  • Plant and animal studies
  • Antifungal resistance and susceptibility
  • French Urban and Social Studies
  • Infectious Diseases and Tuberculosis
  • Mycobacterium research and diagnosis
  • Vector-borne infectious diseases
  • Plant Diversity and Evolution
  • Genital Health and Disease
  • African Botany and Ecology Studies
  • Mediterranean and Iberian flora and fauna
  • Nuclear Receptors and Signaling

Université de Tours
2015-2025

Géographie de l'environnement
2017-2024

Nantes Université
2017-2024

Institut de Virologie
2013-2024

Centre Hospitalier Universitaire de Tours
2014-2024

Hôpital Bretonneau
2012-2023

University of Geneva
2004-2023

Assistance Publique – Hôpitaux de Paris
2022

Université Paris Cité
2018-2022

Inserm
2016-2022

Abstract Background Enterococcus faecalis infective endocarditis (EFIE) is characterized by a higher frequency of relapses than other endocarditis. The role the treatment on its occurrence remains poorly understood. aim this study was to investigate whether antibiotic regimen could impact risk relapse in EFIE. Materials This multicenter retrospective patients diagnosed with definite EFIE between 2015 and 2019 14 French hospitals. primary endpoint within year following diagnosis. As death...

10.1093/cid/ciac777 article EN cc-by-nc-nd Clinical Infectious Diseases 2022-09-19

In the context of increasing antimicrobial resistance in Enterobacterales, management these UTIs has become challenging. We retrospectively assess prevalence Enterobacterales isolates recovered from urinary tract samples France, between 1 September 2017, to 31 August 2018. Twenty-six French clinical laboratories provided susceptibility 134,162 17 antimicrobials. The most frequent species were E. coli (72.0%), Klebsiella pneumoniae (9.7%), Proteus mirabilis (5.8%), and Enterobacter cloacae...

10.3390/pathogens11030356 article EN cc-by Pathogens 2022-03-15

Abstract Background Campylobacter spp. bacteremia is a severe infection. A nationwide 5-year retrospective study was conducted to characterize its clinical features and prognostic factors. Methods The included patients with diagnosed in 37 French hospitals participating the surveillance network of National Reference Center for Campylobacters Helicobacters, from 1 January 2015 31 December 2019. goal analyze effects delay appropriate antibiotic therapy other risk factors on 30-day mortality...

10.1093/cid/ciab983 article EN Clinical Infectious Diseases 2021-11-23

ABSTRACT We evaluated the incidence of Streptococcus pseudopneumoniae in clinical isolates by phenotypic methods and DNA-DNA hybridization. The pathogenic role this organism was investigated with mouse peritonitis/sepsis model. Our results show a low (1/120 pneumococcal isolates) potential effect for S. .

10.1128/jcm.02643-05 article EN Journal of Clinical Microbiology 2006-06-01

In highly anthropogenic plant communities, environmental conditions and human practices play a significant role in the composition, structure diversity of flora. This paper presents study current past floras two habitats (cultivated ruderal) eastern France that have been subject numerous palaeoenvironmental studies (pollen seed analysis). To understand different components constitute biodiversity these floras, it is necessary to develop transdisciplinary method combining ecology,...

10.1177/0959683609336559 article EN The Holocene 2009-08-14

Bartonella is an increasingly isolated emerging pathogen that can cause severe illness in humans, including cat scratch disease (CSD). The bacteria are difficult to grow and thus many detection methods have been developed, especially molecular. We previously developed a PCR method targeting ribC identify sp. A manufactured kit (RealCycler BART, Progenie Molecular) was commercialised shortly thereafter for the of infection, henselae.We performed comparison between this test our in-house assay...

10.1099/jmm.0.000626 article EN Journal of Medical Microbiology 2017-10-25

Tularemia is a rare zoonotic infection caused by bacterium Francisella tularensis. It has been well described in immunocompetent patients but poorly immunocompromised notably solid organ transplant recipients. We report here two cases of tularemia recipients including first case after heart transplant. also carried out an exhaustive review literature describing characteristics this

10.1186/s12879-019-3863-0 article EN cc-by BMC Infectious Diseases 2019-03-08

ANP (atrial natriuretic peptide) is widely recognized as an important vasorelaxant, diuretic, and cardioprotective hormone. Little known, however, about how ANP-secretory vesicles form within the atrial myocytes. Secretory were visualized by fluorescence microscope imaging in live rat myocytes expressing proANP-enhanced green fluorescent protein (EGFP), or N-terminal-mutated fusion proteins thought to suppress calcium-dependent aggregation of proANP. Results showed following: (1) aggregates...

10.1161/01.res.0000150592.88464.ad article EN Circulation Research 2004-11-12

In this multicentric study performed in 12 French hospitals, we reported that 26.9% (14/52) of the amoxicillin-clavulanate-resistant Proteus mirabilis isolates produced OXA-23 carbapenemase. We found an inhibition zone diameter <11 mm around amoxicillin-clavulanate disc was accurate screening cutoff to detect these producers. confirmed by whole-genome sequencing OXA-23-producers all belonged same lineage has been demonstrated disseminate or OXA-58 P. mirabilis.

10.1128/aac.01983-21 article EN Antimicrobial Agents and Chemotherapy 2021-12-21

Abstract Although Candida spp are aerobic microorganisms, some strains, mainly glabrata, can be recovered from anaerobic blood culture vials. We assessed the contribution of vials for diagnosis candidemia, especially C. glabrata. conducted a multicenter retrospective study including eight university or regional hospitals. A single episode monomicrobial candidemia per patient was included September 1st, 2016, to August 31st, 2019. The characteristics all and sampled within 2 h before after...

10.1093/mmy/myac021 article EN Medical Mycology 2022-04-01
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