A5002148538- SARS-CoV-2 detection and testing
- SARS-CoV-2 and COVID-19 Research
- Biosensors and Analytical Detection
- Antibiotic Resistance in Bacteria
- Respiratory viral infections research
- Bacterial biofilms and quorum sensing
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Legionella and Acanthamoeba research
- Urinary Tract Infections Management
- Antibiotic Use and Resistance
- COVID-19 Clinical Research Studies
- Influenza Virus Research Studies
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial Infections and Vaccines
- Long-Term Effects of COVID-19
- Vibrio bacteria research studies
- Advanced biosensing and bioanalysis techniques
- Mycobacterium research and diagnosis
- Pneumonia and Respiratory Infections
- Viral Infections and Outbreaks Research
- Enterobacteriaceae and Cronobacter Research
- Sepsis Diagnosis and Treatment
- Rabies epidemiology and control
- Viral Infections and Vectors
Université Libre de Bruxelles
2020-2025
Antwerp Management School
2024
Institut Gustave Roussy
2019-2023
Universitair Ziekenhuis Brussel
2023
Université Paris-Saclay
2022
Erasmus Hospital
2020
Assistance Publique Hôpitaux de Marseille
2015
Méditerranée Infection Foundation
2015
Deutsches Herzzentrum der Charité
2011
Introduction: COVID-19 Ag Respi-Strip, an immunochromatographic (ICT) assay for the rapid detection of SARS-CoV-2 antigen on nasopharyngeal specimen, has been developed to identify positive patients allowing prompt clinical and quarantine decisions. In this original research article, we describe conception, analytical performances as well risk management implementing Respi-Strip in a diagnostic decision algorithm. Materials Methods: Development resulted ready-to-use ICT based membrane...
Abstract Objectives In August 2018, a public health alert was issued in Belgium regarding clusters of impetigo cases caused by the epidemic European fusidic acid-resistant clone (EEFIC) Staphylococcus aureus. As result, Belgian national reference centre (NRC) commissioned to update epidemiology S. aureus causing community-onset skin and soft tissues infection (CO-SSTI) assess proportion EEFIC among them. Methods For 1 year, clinical laboratories were asked send their first three isolated...
We evaluated the quantitative DiaSorin Liaison severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen test in symptomatic and asymptomatic individuals consulting their general practitioners (GPs) during a period of stable intense virus circulation (213/100,000 habitants per day). Leftover reverse transcription-PCR (RT-PCR) positive (n = 204) negative 210) nasopharyngeal samples were randomly selected among fresh routine collected from patients GPs. Samples tested on XL...
In the context of increasing antimicrobial resistance in Enterobacterales, management these UTIs has become challenging. We retrospectively assess prevalence Enterobacterales isolates recovered from urinary tract samples France, between 1 September 2017, to 31 August 2018. Twenty-six French clinical laboratories provided susceptibility 134,162 17 antimicrobials. The most frequent species were E. coli (72.0%), Klebsiella pneumoniae (9.7%), Proteus mirabilis (5.8%), and Enterobacter cloacae...
From early 2020, a high demand for SARS-CoV-2 tests was driven by several testing indications, including asymptomatic cases, resulting in the massive roll-out of PCR assays to combat pandemic. Considering dynamic viral shedding during course infection, report cycle threshold (Ct) values rapidly emerged. As Ct can be affected number factors, we considered that harmonization semi-quantitative results across laboratories would avoid potential divergent interpretations, particularly absence...
Introduction: Since the first wave of COVID-19 in Europe, new diagnostic tools using antigen detection and rapid molecular techniques have been developed. Our objective was to elaborate a algorithm combining tests, automated dosing tests assess its performance under routine conditions. Methods: An analytical evaluation four one point-of-care test performed on samples sent our laboratory for SARS-CoV-2 reverse transcription PCR. We then established by approaching median viral loads target...
Introduction: We assessed the usefulness of SARS-CoV-2 RT-PCR cycle thresholds (Ct) values trends produced by LHUB-ULB (a consolidated microbiology laboratory located in Brussels, Belgium) for monitoring epidemic's dynamics at local and national levels improving forecasting models. Methods: Ct from April 1, 2020, to May 15, 2021, were compared with COVID-19 confirmed cases notifications according their geographical time distribution. These evaluated against both a phase diagram predicting...
Klebsiella aerogenes has recently been reported as a causative agent of folliculitis in men who have sex with (MSM). We present four cases MSM diagnosed Brussels, Belgium. Patients were aged between 25 and 50 years, all infected by single multilocus sequence type (ST117) strain. This strain carried the yersiniabactin siderophore genes. Following preliminary treatment sulfamethoxazole−trimethoprim for 7−14 days, patients experienced recurrence symptoms, necessitating an extended therapeutic regimen.
Whether the risk of multidrug-resistant bacteria (MDRB) acquisition in intensive care unit (ICU) is modified by COVID-19 crisis unknown. In this single center case control study, we measured rate MDRB patients admitted ICU and compared it with same for subarachnoid hemorrhage (controls) matched 1:1 on length stay mechanical ventilation. All were systematically repeatedly screened carriage. We using a competing analysis. Of note, although tried to match septic shock patients, unable due...
Journal Article Cutaneous and pulmonary dirofilariasis due to Dirofilaria repens Get access M. Benzaquen, Benzaquen Service de Dermatologie Hôpital Nord Assistance Publique – Hôpitaux Marseille 13015 France Search for other works by this author on: Oxford Academic Google Scholar D. Brajon, Brajon Delord, Delord Pole Maladies Infectieuses N. Yin, Yin F. Bittar, Bittar Faculté Médecine Unité Recherche sur les Transmissibles et Emergentes (URMITE), UM63, CNRS 7278, IRD 198, Inserm 1095 Aix...
Introduction Using respiratory virus rapid diagnostic tests in the emergency department could allow better and faster clinical management. Point-of-care PCR instruments now provide results less than 30 minutes. The objective of this study was to assess impact use a molecular test, cobas® Influenza A/B & RSV Assay, during management patients. Methods Patients (adults children) requiring admission or suffering from an underlying condition at risk complications were prospectively recruited...
An international outbreak of the monkeypox (MPX) virus is ongoing with a different clinical presentation than previously reported.A monocentric retrospective study was designed to investigate predictors confirmed MPX cases among group patients referred for screening. Furthermore, additional value performing real-time polymerase chain reaction (RT-PCR) on multiple anatomical sites analyzed.Between 28/05/2022 and 22/07/2022, medical records screening were investigated. Patients positive RT-PCR...
Background Antimicrobial resistance to mupirocin and fusidic acid, which are used for treatment of skin infections caused by Staphylococcus aureus, is concern. Aim To investigate acid in meticillin-susceptible S. aureus (MSSA) from community-acquired soft tissue (SSTIs) Belgium. Methods We collected 2013–2023 data on SSTI-associated MSSA two large Belgian laboratories. Resistant isolates sent the Staphylococci Reference Centre were spa -typed analysed presence eta etb virulence genes mupA...
Abstract Background: Whether the risk of multidrug resistant bacteria (MDRB) acquisition in intensive care unit (ICU) is increased during COVID-19 crisis unknown. Our aim was to measure rate MDRB patients admitted ICU and compare it with pre-COVID-19 controls. Methods: This single center case control study included adult ICUs for more than 48h. Patients were screen twice a week carriage stay. We compared cohort subarachnoid hemorrhage (SAH) matched on length stay using competing analysis....
Laryngeal tuberculosis is a rare and often misdiagnosed disease. Its diagnosis based on the association of laryngeal lesion microbiological detection Mycobacterium tuberculosis. Stool cultures have recently been described as useful tool in atypical forms In this report, we describe first case literature diagnosed by culture stool samples. A 41-year-old French Caucasian man was admitted to our hospital for dysphonia 3 months’ evolution. biopsy performed because suspicion carcinoma. He had no...
Background The European Medicines Agency has approved several vaccines to protect the elderly against respiratory syncytial virus (RSV) infections. However, differences in performance between antigen and PCR tests, especially adults, can make monitoring RSV difficult. This study aims assess impact of chosen diagnostic methods on surveillance RSV. Methods influenza test results obtained from July 2022 June 2023 a consolidated clinical laboratory Brussels, Belgium, were collected. These...
Legionella pneumophila can cause a large panel of symptoms beside the classic pneumonia presentation. We present here case fatal nosocomial cellulitis in an immunocompromised patient followed, year later, by second legionnaires’ disease same ward. While first one was easily assumed as based on date onset, other needed to rely clear typing results be either assigned and related environmental source one, or community acquired. To untangle this specific question, we applied Core-genome...
Legionella pneumophila can cause a large panel of symptoms besides the classic pneumonia presentation. Here we present case fatal nosocomial cellulitis in an immunocompromised patient followed, year later, by second Legionnaires’ disease same ward. While first was easily assumed as based on date symptom onset, required clear typing results to be assigned either and related environmental source case, or community acquired. To untangle this specific question, applied core-genome multilocus...
The role of meteorological factors, such as rainfall or temperature, key players in the transmission and survival infectious agents is poorly understood. aim this study was to compare surveillance data with epidemiological Belgium investigate association between intense weather events occurrence diseases. Meteorological were aggregated per Belgian province obtain weekly average temperatures categorized according distribution variables. Epidemiological included cases reported pathogens...