Marlène Amara
A5014225865- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Antibiotic Use and Resistance
- Antimicrobial Resistance in Staphylococcus
- Nosocomial Infections in ICU
- Streptococcal Infections and Treatments
- Pneumonia and Respiratory Infections
- Infective Endocarditis Diagnosis and Management
- Antibiotics Pharmacokinetics and Efficacy
- Urinary Tract Infections Management
- Enterobacteriaceae and Cronobacter Research
- Amoebic Infections and Treatments
- Microbial infections and disease research
- Respiratory Support and Mechanisms
- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- Orthopedic Infections and Treatments
- Infections and bacterial resistance
- Mycobacterium research and diagnosis
- Bacterial Infections and Vaccines
- Jewish and Middle Eastern Studies
- Diphtheria, Corynebacterium, and Tetanus
- Veterinary medicine and infectious diseases
- Multilingual Education and Policy
- Virology and Viral Diseases
Centre Hospitalier de Versailles
2015-2024
Hôpital André Mignot
2018-2023
Centre Val de Loire
2021
Centre Hospitalier Universitaire de Tours
2012
Bar-Ilan University
2006
Centre Hospito Universitaire de Sétif
1983
In the context of increasing antimicrobial resistance in Enterobacterales, management these UTIs has become challenging. We retrospectively assess prevalence Enterobacterales isolates recovered from urinary tract samples France, between 1 September 2017, to 31 August 2018. Twenty-six French clinical laboratories provided susceptibility 134,162 17 antimicrobials. The most frequent species were E. coli (72.0%), Klebsiella pneumoniae (9.7%), Proteus mirabilis (5.8%), and Enterobacter cloacae...
The population structure of extraintestinal pathogenic Escherichia coli evolves over time, notably due to the emergence antibiotic-resistant clones such as ESBL-producing Enterobacteriaceae (ESBL-E).To analyse by WGS genetic diversity a large number ESBL-E isolated from urinary tract infections in children paediatric centres across France between 2014 and 2017 collected National Observatory febrile infection (FUTI) caused ESBL-E.A total 40 905 Enterobacteriaceae-positive urine cultures were...
Patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-COV 2) and requiring intensive care unit (ICU) have a high incidence of hospital-acquired infections; however, data regarding hospital acquired bloodstream infections (BSI) are scarce. We aimed to investigate risk factors outcome BSI in critically ill infectious disease-19 (COVID-19) patients.We performed an ancillary analysis multicenter prospective international cohort study (COVID-ICU study) that included...
Abstract Background Achromobacter spp. are opportunistic pathogens, mostly infecting immunocompromised patients and with cystic fibrosis (CF) considered as difficult-to-treat pathogens due to both intrinsic resistance the possibility of acquired antimicrobial resistance. Species identification remains challenging leading imprecise descriptions in each taxon. Cefiderocol is a broad-spectrum siderophore cephalosporin increasingly used management infections for which susceptibility data remain...
Limited pharmacokinetics data support dalbavancin long-term use in off-label indications and the optimal dosing regimen is debated. We aimed to describe concentrations an observational retrospective multicentre study.
Colistin resistance in Acinetobacter baumannii often results from mutational activation of the two-component system PmrAB and subsequent addition phospho-ethanolamine (pEtN) to lipooligosaccharide by up-regulated pEtN transferase PmrC.To characterize mechanisms colistin independent PmrCAB A. baumannii.Twenty-seven colistin-resistant were collected 2012 2018. Analysis operon pmrCAB was performed PCR sequencing. Seven strains investigated further WGS whole-genome MLST (wgMLST).Seven out 27...
Actinobaculum schaalii is a Gram-positive facultative anaerobe bacillus. It commensal organism of the genitourinary tract. Its morphology nonspecific. Aerobic culture tedious, and identification techniques have long been inadequate. Thus, A. has often considered as nonpathogen bacterium or contaminant. pathogenicity now well described in urinary tract infections, infections other sites reported. This pathogen an emerging one following growing use mass spectrometry identification. In this...
Abstract Background The resistance to all aminoglycosides (AGs) conferred by 16S rRNA methyltransferase enzymes (16S-RMTases) is a major public health concern. Objectives To characterize the genotype, its genetic environment and plasmid support, phylogenetic relatedness of 16S-RMTase-producing Escherichia coli from France. Methods We screened 137 E. isolates resistant clinically relevant AGs nine Parisian hospitals for 16S-RMTases. WGS was performed on clinical with high-level AG (MIC ≥256...
Abstract Background Description and comparison of bacterial characteristics ventilator-associated pneumonia (VAP) between critically ill intensive care unit (ICU) patients with COVID-19-positive, COVID + ; non-COVID-19, COVID-. Methods Retrospective, observational, multicenter study that focused on French during the first wave pandemic (March–April 2020). Results 935 identification at least one bacteriologically proven VAP were included (including 802 +). Among Gram-positive bacteria, S....
To evaluate the association between ventilator type and hospital mortality in patients with acute respiratory distress syndrome (ARDS) related to COVID-19 (SARS-CoV2 infection), a single-center prospective observational study France. We prospectively included consecutive adults admitted intensive care unit (ICU) of university-affiliated tertiary for ARDS proven COVID-19, March 2020 July 2021. All were intubated. compared two patient groups defined by whether an ICU or less sophisticated such...
Abstract Background Quinolone resistance (QR) is one component of the MDR emerging in Escherichia coli and particular concern given widespread use fluoroquinolones. Objectives To characterize QR phenotypes genotypes E. responsible for bloodstream infections to propose molecular determinants that could be targeted predict ciprofloxacin resistance. Methods isolates from blood cultures three French hospitals were studied quinolone MICs characterization genotypic (QRg). Results Among 507 tested...
Achromobacter spp. are nonfermenting Gram-negative bacilli mainly studied among cystic fibrosis (CF) patients. The identification of the 19 species within genus is time-consuming (nrdA-sequencing), thus data concerning distribution limited to specific studies. Recently, we built a database using MALDI-TOF mass spectrometry (MS) (Bruker) that allows rapid and accurate detection multiresistant epidemic clones: A. xylosoxidans ST137 spreading CF patients in various French Belgium centers,...
the analyses, because these data were only available for a limited number of patients.Using albuminuria and proteinuria would have caused substantial selection bias.Second, not all creatinine values measured by same laboratory or assay due to design database, which collects from practices throughout Flanders.However, Belgian laboratories are subject quality control measures (http://www.iph.fgov.be/ClinBiol/bckb33/activities/external_quality/rapports/_down/ klinische_...
Abstract Although Candida spp are aerobic microorganisms, some strains, mainly glabrata, can be recovered from anaerobic blood culture vials. We assessed the contribution of vials for diagnosis candidemia, especially C. glabrata. conducted a multicenter retrospective study including eight university or regional hospitals. A single episode monomicrobial candidemia per patient was included September 1st, 2016, to August 31st, 2019. The characteristics all and sampled within 2 h before after...